key: cord-0937365-wecgp82b
authors: Langer, Miriam D.; Silver, Ellen J.; Dodson, Nancy A.; Talib, Hina J.; Coupey, Susan M.
title: Fertility Desires of Adolescent Females: Decreased Desire for Children in Those Identifying as Transgender/Gender Diverse and in Depressed Adolescents
date: 2020-09-12
journal: J Pediatr Adolesc Gynecol
DOI: 10.1016/j.jpag.2020.09.001
sha: aadb490795d95705456e3bbe511ad84e4b09c727
doc_id: 937365
cord_uid: wecgp82b

Study Objective We aimed to describe fertility desires in healthy adolescent females and to explore associations of fertility desire with conditions and therapies potentially compromising fertility. Design Cross-sectional, anonymous survey Setting and Participants: 323 females aged 13-19 years recruited from clinic waiting areas at a children’s hospital. We oversampled on days when clinics serving adolescents with potential fertility compromise were scheduled. Main Outcome Measures We measured fertility desire by agreement with the statement “I want to have children someday”. To measure compromised fertility we asked “In the past year, has a doctor, nurse or other medical professional ever talked to you about the possibility that you may have decreased fertility and may not be able to have your own biological child someday?”. To measure depression severity, we used the PHQ-9 scale; scores were dichotomized into no/mild and moderate/severe. Results Mean age was 16.06±1.87 years; 57% Hispanic, 24% black; 93.5% cisgender, 6.5% transgender/gender diverse; 70% heterosexual, 30% sexual minority; 35% moderate/severe depression; 12% compromised fertility. Overall, 89% wanted children. Fewer transgender/gender diverse than cisgender participants wanted children [67% v. 93%, p <0.001] as did fewer with moderate/severe v. no/mild depression [83% v. 93%, p<0.05], while those with compromised fertility v. those without and heterosexual v. sexual minority participants had similar fertility desires. Transgender/gender diverse identity [OR, 0.33; 95%CI, 0.11-0.97; p<0.05] and moderate/severe depression [OR, 0.45; 95%CI, 0.22-0.93; p<0.05] were independently associated with lower fertility desire. Conclusions We found a high overall proportion of adolescent females desiring future children and only two independent predictors of decreased fertility desire: transgender/gender diverse identity and moderate/severe depression.

The past two decades have seen considerable interest in fertility preservation methods for adolescents who are facing medical treatments that may compromise their fertility, such as chemotherapy and radiation. 1, 2 More recently with the increase in provision of gender-affirming care for transgender and gender diverse adolescents, practice guidelines have been developed recommending counseling about options for fertility preservation prior to initiating such therapy as it may have irreversible adverse effects on fertility. 3, 4 Cryopreservation of sperm is relatively straight forward, but the options to preserve ovarian tissue or oocytes is invasive, time-consuming, costly and not guaranteed to result in a fertilized embryo in the future. 5 It is not surprising that adolescents assigned female at birth undergoing fertility compromising therapy often refuse fertility preservation measures. 6, 7, 8 We do not know, however, whether refusal of fertility preservation is based on a lack of desire for children or on other factors. A 2009 systematic review of fertility desires and intentions among adults with HIV/AIDS noted that fertility desires are influenced by many cultural, demographic, health, stigma-associated and psychosocial factors and we expect that the influences are similar for adolescents. 9 Little is known about the fertility desires of healthy adolescent girls, making it difficult to interpret the choices made by girls with potential fertility compromise.

Investigations of fertility desires over the life course in a prospective study of a British birth cohort found that for adolescent females interviewed at age 16, few respondents wanted none or just one child and increased academic ability was J o u r n a l P r e -p r o o f associated with the desire to remain childless. 10 A 2006 study of 12-to 17-yearold adolescents recruited from a predominately low-income, African American neighborhood in San Francisco found that 80% of the 166 female participants reported that having children in the future was important to them. 11 A qualitative study designed to assess female adolescents' attitudes toward fertility and cancer conducted focus groups utilizing hypothetical scenarios with 25 primarily white and Asian, healthy 12-to-18-year-old girls in Florida. 1 All except one of the girls indicated that they would like to have a baby in the future and would be "sad", "disappointed" and "upset" if they found out they could not have children because of cancer treatment.

In contrast, studies show that when fertility counseling is routinely provided to transgender youth prior to initiation of hormonal therapy, few utilize the fertility preservation services available; this is particularly true of those in the transmasculine spectrum (assigned female at birth). 7, 8 In a chart review study of 73 youth aged 9 to18 years at initiation of gender-affirming therapy, accessing care through the gender management program at Nationwide Children's Hospital, 98% received fertility counseling but only 2 transgender females opted to preserve their sperm. 8 This study found that 16% of the transgender males refused fertility preservation because they stated that they never wanted to have children.

J o u r n a l P r e -p r o o f To our knowledge, a direct comparison of fertility desires of adolescent females with no fertility compromise to those with potential fertility compromise related to health conditions as well as medical treatments has not been done. In this study, we aimed to describe fertility desires in adolescent females without known fertility compromise and to explore associations of fertility desires with conditions and treatments potentially compromising fertility as well as with sociodemographic, behavioral, and mental health variables.

From August 2019 through February 2020, trained research assistants approached all individuals who appeared to be adolescent females in the emergency room waiting area and the common waiting rooms for subspecialty clinics affiliated with an academic children's hospital located in Bronx County, NY, a dense, low-resource urban area. The research assistants read a brief script to those individuals who acknowledged that they were aged 13-19 years to invite them to complete an anonymous, online survey on provided electronic tablets. We described the purpose of the survey as being about "young people's future plans for their education and family". We prioritized recruitment to oversample the waiting rooms of the subspecialty clinics on days when clinics serving children with potentially fertility compromising conditions were scheduled, e.g. adolescent medicine/gynecology, endocrinology, rheumatology, and gender care clinics. On days when a gender care clinic was scheduled, we used a J o u r n a l P r e -p r o o f modified recruitment strategy where the research assistants approached both male-and female-appearing adolescents to capture masculinized youth who were assigned female at birth.

We did not recruit adolescents who were outside the age range, unable to understand the description of the survey, or if an accompanying parent refused to allow their child to participate. We excluded from analysis any adolescents who answered "male" to the survey question "What gender were you assigned at birth, on your original birth certificate?" The Albert Einstein College of Medicine institutional review board approved the study with a waiver of parental consent via "opt out" for participants aged 13-17 years. We obtained a waiver of signed documentation of consent to preserve anonymity for participants aged 18 and19 years as the consent document is the only identifiable link between the subject and the research.

We approached 497 individuals and 411 (83%) completed the survey. Of those completing the survey, 88 natal males were excluded. We analyzed survey responses from 323 natal female adolescents.

We developed, piloted for comprehension, and revised a 50-item survey for this study, adapting questions from previously published studies when available and developing new questions as needed. Demographic and sexual history questions were adapted from the Youth Risk Behavior Survey. 12 Questions about J o u r n a l P r e -p r o o f gender identity were adapted from a study by Reisner et al. 13 Questions about fertility attitudes were adapted from a questionnaire developed by Strang et al. 14 and other fertility questions were adapted from a survey of adolescent patients with cancer by Kloskly et al. 2 To assess our primary outcome measure, fertility desire, we utilized the statement " I want to have children someday" scored with a 4-point Likert scale ranging from strongly agree to strongly disagree. For analysis, we combined strongly agree and agree to indicate an affirmative answer. We measured potentially compromised fertility with the question "In the past year, has a doctor, nurse or other medical professional ever talked to you about the possibility that you may have decreased fertility and may not be able to have your own biological child someday?" This question was preceded in the survey with a definition of "biological child", "…it is important to know that "Biological Child" means a child born with your own eggs or sperm". For those answering this question affirmatively, we asked them to write in the name of the condition potentially causing decreased fertility. In addition, we incorporated into the survey a validated scale to measure depression severity, the PHQ-9. 15 This scale is scored from 1 through 27, with scores of 10-16 indicating moderate depression, 17-20 moderate/severe depression, and 21-27 severe depression.

For analysis, we dichotomized scores of <10 as no or mild depression and ≥10 as moderate or severe depression.

We first used chi-square analysis to look at bivariate associations of sociodemographic, behavioral and fertility characteristics with fertility desire (i.e., J o u r n a l P r e -p r o o f I want to have children someday). We then used binary logistic regression to determine which variables found to be significant in bivariate analyses were independently associated with wanting children. IBM SPSS Statistics Version 25 was used for all analyses and a p-value < 0.05 was considered statistically significant.

Of 323 participants, the mean age was 16.06 ± 1.87 years (Table 1) . Most selfidentified as either Hispanic or Black and were enrolled in middle or high school.

More than 90% reported their gender identity as female and 21 (6.5%) participants reported their gender identity as transgender, non-binary, gender queer or something else. In this sample of adolescents assigned female at birth, 70% identified their sexual orientation as heterosexual, while 30% identified as bisexual, gay/lesbian or unsure. Just under one third of participants (32%) had ever had sex, and just over one third (35%) screened positive for moderate or severe depression.

A large majority (89%) of participants agreed that they wanted to have children someday (Table 1) . Thirty-eight participants (12%) reported they had been told by a medical professional that they may have decreased fertility and may not be able to have a biological child. The conditions related to the possible fertility J o u r n a l P r e -p r o o f compromise that participants wrote in on the survey included: polycystic ovary syndrome/irregular periods (n=9); testosterone shot/injection (n=5); hypo/hyper thyroid (n=4); lupus (n=4); Turners/HRT/ovarian failure (n=3); anorexia/eating disorder (n=2); and PID, endometriosis, heart condition, nephrotic syndrome (n=1 each).

We found no sociodemographic differences in the proportions of participants who answered affirmatively to our primary outcome measure "I want to have children someday" (Table 2) . Consistent with our hypothesis, we found that adolescent participants who self-identified as transgender/gender diverse were significantly less likely to desire future children than cisgender girls [67% vs. 90%, p<0.001].

Participants with health conditions who had been told by a medical professional that they may have decreased fertility had similar fertility desires as those without such conditions [84% vs.89%, p=0.377] as did those who self-identified as heterosexual/straight compared with those identifying as sexual minority [90% vs. Table 3 ).

To our knowledge, this is the first study to directly compare desire for future children in a large sample of over 300 teenaged girls, 13 to 19 years old, with and without potential fertility compromising conditions or therapies. We found, as have others, that the large majority, 89%, of the teens we surveyed wanted to have children someday. Our finding is nearly identical to that reported in a study of fertility desires and intentions of U.S. women using data from the 2011-2013 National Survey of Family Growth. 16 That study found that among the 1,568 nondisabled adolescent and young adult women aged 15-24 years, 89.1% wanted "to have a baby at some time in the future". For participants in our study with gynecologic, endocrinologic or other chronic health conditions who had been told by a medical professional that they may have compromised fertility, we found no difference in their desire for children from those without such conditions. However, among participants identifying as transgender as well as gender nonbinary, gender queer or something else, we found significantly decreased desire for future children when compared with their cisgender female peers.

Transgender/gender diverse adolescents assigned female at birth had only about one third the odds of desiring children as cisgender girls. While we found no differences in desire for future children by age, race/ethnicity, education, sexual orientation or sexual behavior, we found that adolescent females who screened positive for moderate or severe depression had less than half the odds of desiring children than those with no or mild depression. A transgender/gender diverse identity and moderate/severe depression each were independent predictors of decreased fertility desires in these adolescents assigned female at birth.

Clinical experience and the findings of this study suggest that transgender/gender diverse adolescents assigned female at birth may envision their lives differently from cisgender girls; they are more likely to see a future without children. This may, in part, be influenced by exclusion of transgender people from traditional institutions, so they may not feel entitled to normal life milestones including marriage and parenthood. We found a considerable number of teens in our sample who reported their sexual orientation as lesbian, gay, bisexual or questioning. Despite belonging to another traditionally marginalized group, this group of sexual minority participants had similar fertility desires to their heterosexual peers; they were envisioning a future with children, unlike many of their transgender/gender diverse peers. Possibly our lesbian, gay and bisexual teens can imagine a future with children because legalization of gay marriage has placed them closer to the mainstream whereas our J o u r n a l P r e -p r o o f transgender/gender diverse teens cannot see themselves or their futures in the same way.

Another plausible explanation for our finding of decreased fertility desires specifically in transgender/gender diverse adolescents assigned female at birth includes dysphoria related to their reproductive anatomy, especially breasts and uterine bleeding. 17, 18 Many transgender and gender diverse adolescents may be unwilling even to consider the reproductive functions of these organs, especially as their pubertal maturation may be a new and potentially unwanted experience for them. Indeed, many transmasculine teens bind their breasts and seek menstrual suppression from their health care providers as these organs and bodily functions can cause significant distress and exacerbate gender dysphoria. 18 In addition, transmasculine teens may worry that if they endorse a desire to be pregnant or have a baby one day, it will make their health care providers less likely to prescribe gender-affirming hormones. Nonetheless, while we found that transgender/gender diverse adolescents assigned female at birth had decreased desire for future children when compared with cisgender girls, still more than 60% of the transgender/gender diverse teens desired future children.

A study on desire for children among German transgender adults found that prior to gender affirming treatment, about half (46%) of trans men (median age 25 years) indicated that having children was important to them, a proportion not dissimilar to our finding in younger adolescents. 19 J o u r n a l P r e -p r o o f While depression is common among transgender and gender diverse adolescents, 20 our analysis indicates that our finding of decreased fertility desires in depressed adolescent females is independent of gender identity. The relatively high rate of just over one third of our sample of adolescents screening positive for moderate to severe depression is nearly identical to the rate of depression our group found in a previous study of a similar population of adolescent girls living in Bronx County, NY, a low resource, high-poverty, urban community. 21 Adolescent depression is associated with adverse childhood experiences including family dysfunction, sexual and physical abuse, and poverty all of which may discourage adolescent girls from wanting to start their own families and become parents. 22 Adverse childhood experiences are prevalent in our Bronx adolescent population 21 and our finding of association of depression with decreased fertility desires in adolescent girls may be mediated by this stressful environment and may not be generalizable to adolescents living in different environments.

Primary symptoms of depression are hopelessness, anhedonia, and lack of future focus or hope for the future that may manifest in adolescent girls as a belief that they will not have 'the good things in life' including a family and children. A comparison of depressed and non-depressed adults found that depression is associated with reduced positive future thinking. 23 It is important for clinicians to consider that depression may color an adolescent's stated fertility desires. For example, a girl with depression who reports little interest in having children in the future may be expressing her hopelessness about a bright future, J o u r n a l P r e -p r o o f rather than a deeply held, well-developed attitude about her fertility. Depression is a treatable condition, and so decreased desire for future children in depressed adolescent girls may change with successful treatment and lifting of the depression.

The strengths of this study are the relatively large overall sample size and recruitment of gender diverse adolescents assigned female at birth and girls with potentially compromised fertility allowing meaningful comparisons to be made.

Limitations include that this is a sample of mostly racial and ethnic minority girls from a high-poverty urban community and thus may not be generalizable to other populations of teens. In addition, the cross-sectional nature of the study does not allow for assessment of changes in fertility desire over time.

In conclusion, in this sample of 13-to-19-year-old adolescents assigned female at birth we found a high overall proportion of participants wanting to have children someday. We found only two independent predictors of decreased fertility desire which were transgender/gender diverse identity and moderate to severe depression. It may be useful to conduct further studies to explore this association. For example, if gender dysphoria or depressive symptoms are a critical influence on fertility desire, it would be useful to explore whether intervention could modify this relationship. Alleviation of gender dysphoria with gender affirming hormones and/or successful treatment of depression may alter a person's desire for children. Moreover, longitudinal studies are needed to J o u r n a l P r e -p r o o f assess if fertility desire changes over time in both transgender/gender diverse teens and those who are depressed and to identify factors associated with those changes. Recent studies indicate that successful oocyte retrieval for cryopreservation may occur after several years of testosterone therapy in transmasculine individuals and successful pregnancies may occur in women who had harvesting of ovarian tissue for cryopreservation after exposure to chemotherapy. 5, 24 As such, we continue to think it is important to periodically revisit conversations of desire for children and offers of fertility preservation with transgender/gender diverse adolescents assigned female at birth, even after initiation of gender affirming hormones, and with adolescent girls with cancer and other fertility compromising conditions even after treatment has begun. 

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J o u r n a l P r e -p r o o f