key: cord-0936485-e357zmsj authors: Maggio, Roberto; Corsini, Giovanni U. title: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection date: 2020-04-22 journal: Pharmacol Res DOI: 10.1016/j.phrs.2020.104837 sha: d33af568930f084a27b4f7ca97d1c7645bac91c3 doc_id: 936485 cord_uid: e357zmsj nan Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection We thank Dr. Mark J. Millan for helpful discussions and comments on the letter. We declare no competing interests. J o u r n a l P r e -p r o o f The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections