key: cord-0936308-2vd9khfk authors: Pechanova, Olga title: Why We Still Need Reliable Animal Models date: 2020-12-14 journal: Pathophysiology DOI: 10.3390/pathophysiology27010006 sha: 8337fe1cabfc7dedc53788eeb530a4b37d6ad8ef doc_id: 936308 cord_uid: 2vd9khfk Animal models are still an essential tool for identifying key molecular mechanisms and pathophysiological manifestations of different diseases, as well as for the analysis of the most effective intervention for the treatment and reduction of the consequences of pathophysiological conditions [...]. Pathophysiology 2020, 27 intervention can induce ARDS-like lung damage. The development of a rat model for monitoring the consequences of COVID-19 would bring new possibilities for monitoring drugs and substances that have the potential to treat COVID-19. Future studies are needed to standardize the relevant rat model of COVID-19 and protocols to allow comparisons of different drug candidate interventions. We would like to invite all scientists and clinicians to send in their experimental and review articles devoted to the research of pathophysiological mechanisms of diseases, including COVID-19, on animal models to Pathophysiology [11] , the flagship journal of the International Society for Pathophysiology (ISP) [12] . The author declares no conflict of interest. Severe COVID-19: A Review of Recent Progress With a Look Toward the Future. Front. Public Health Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A meta-analysis Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 SARS-CoV-2 is transmitted via contact and via the air between ferrets Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility Discovery of Novel Human and Animal Cells Infected by the Severe Acute Respiratory Syndrome Coronavirus by Replication-Specific Multiplex Reverse Transcription-PCR Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 Selection of animal models for COVID-19 research Animal models for COVID-19 International Society of Pathophysiology Homepage