key: cord-0932988-cmn3gpi2 authors: Koike, Haruki; Katsuno, Masahisa title: Emerging infectious diseases, vaccines and Guillain–Barré syndrome date: 2021-05-17 journal: Clin Exp Neuroimmunol DOI: 10.1111/cen3.12644 sha: 967f2794ef34308c005460be10e471b3e36e8d47 doc_id: 932988 cord_uid: cmn3gpi2 The recent outbreak of Zika virus infection increased the incidence of Guillain–Barré syndrome (GBS). Following the first reported case of GBS after Zika virus infection in 2013, there has been a considerable increase in the incidence of GBS in endemic countries, such as French Polynesia and Latin American countries. The association between coronavirus disease 2019 (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), and GBS is another emerging research hotspot. Electrophysiological studies have suggested that GBS patients associated with Zika virus infection or COVID‐19 tend to manifest acute inflammatory demyelinating polyneuropathy, rather than acute motor axonal neuropathy (AMAN). Causative autoantibodies, such as anti‐ganglioside antibodies in AMAN associated with Campylobacter jejuni infection, have not been identified in GBS associated with these emerging infectious diseases. Nevertheless, recent studies suggested molecular mimicry between these viruses and human proteins related to GBS. Recent studies have shown the efficacy of new vaccines, containing artificial messenger RNA encoding the spike protein of SARS‐CoV‐2, against. These vaccines are now available in many countries and massive vaccination campaigns are currently ongoing. Although there are long‐standing concerns about the increased risk of GBS after inoculation of conventional vaccines, the risk of GBS is not considered a legitimate reason to limit administration of currently available vaccines, because the benefits outweigh the risks. of GBS and its variant, Miller Fisher syndrome, characterized by acute ophthalmoplegia, gait ataxia and areflexia. [5] [6] [7] [8] The recent outbreak of Zika virus infection led to increased incidence of GBS. 9, 10 Furthermore, the association between coronavirus disease 2019 and GBS has also been investigated. [11] [12] [13] In this article, we review the evidence regarding the relationship between emerging infectious diseases (such as Zika virus infection and COVID -19) and GBS. The contemporary knowledge about postvaccination GBS is also summarized. Zika virus is a single-strand RNA virus of the Fraviviridae family transmitted to humans by mosquitoes, such as Aedes aegypti and Aedes albopictus. 14 Human-to-human transmission also occurs through sexual contact, blood infusion or organ transplantation. [15] [16] [17] Most people infected with Zika virus are asymptomatic, whereas approximately 20% people experience symptoms (referred to as Zika fever), such as fever, headache, posterior orbital pain, conjunctival hyperemia, arthralgia, myalgia and skin rash. 14, 18 The incubation period of the disease ranges from 2 to 7 days. 18 20 During this epidemic, a variety of neurological manifestations, including GBS, myelitis, meningoencephalitis and microcephaly, were recognized to be associated with Zika virus infection. 9, 18, 21, 22 The first reported case of GBS associated with Zika virus infection was a middle-aged woman in French Polynesia. 23 The patient manifested rapidly developing sensorimotor neuropathy 1 week after the onset of Zika fever in November 2013 and recovered after intravenous immunoglobulin therapy. 23 21 As compared with the pre-Zika era, the incidence of GBS increased 5.1-fold in Rio de Janeiro, Brazil; 2.7-fold in Bahia state, Brazil; 3.1-fold in Colombia; 2.5-fold in the Dominican Republic; 2.0-fold in El Salvador; 2.4-fold in Honduras; 5.0-fold in Suriname; and 9.8-fold in Venezuela. 10, 24 Electrophysiological features of GBS associated with Zika virus infection are usually consistent with those of AIDP, such as slowing of conduction velocity and prolongation of distal motor latency. 25 According to representative studies carried out in French Polynesia, Colombia and Brazil, the median duration from the onset of Zika fever to that of GBS was 6, 7 and 10 days, respectively. 9,21,24 Clinical features are characterized by predominant lower-limb weakness and frequent facial nerve palsy accompanied by sensory and autonomic disturbances. 9, 21, 24 Bulbar palsy and respiratory muscle paralysis were also frequently seen, necessitating care in the intensive care unit. 26 Magnetic resonance imaging showed gadolinium enhancement of facial nerves, spinal nerve roots and the dorsal root ganglia. 24, 27 Increased protein level in the cerebrospinal fluid with normal cell count was observed in most patients. 9, 21 Plasma exchange and intravenous immunoglobulin are effective treatment modalities for GBS. 1 The therapeutic strategy for GBS associated with Zika virus infection is currently based on evidence pertaining to ordinary GBS patients. 9, 24, 25 According to studies carried out in French Polynesia, Colombia and Brazil, intensive care unit admission was required in 38%, 59% and 15% of patients, and mechanical ventilation was required in 29%, 31% and 7% of patients, respectively. 9, 21, 24 The mortality rate in these studies was 0%, 4% and 4%, respectively. 9, 21, 24 The prognosis seems to be similar to that of ordinary GBS patients. 28 COVID-19 is an infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is also a single-strand RNA virus of the Coronaviridae family. 29 Personto-person transmission of SARS-CoV-2 mainly occurs through respiratory droplets. 29 SARS-CoV-2 infection might be asymptomatic or it might cause a wide spectrum of symptoms, ranging from mild symptoms of upper respiratory tract infection to life-threatening acute respiratory distress syndrome. 30 This virus was first detected in Wuhan, China, in December 2019, and rapidly spread throughout the world. 31 During this pandemic, several neurological manifestations, such as stroke, olfactory-gustatory dysfunction (i.e. anosmia and aguesia), encephalitis, myelitis and GBS, were suggested to be associated with SARS-CoV-2 infection. 32 The first reported case of GBS associated with SARS-CoV-2 infection was a 61-year-old woman who had a travel history to Wuhan. 33 The patient manifested rapidly developing weakness on 23 January 2020 and recovered after intravenous immunoglobulin therapy. Chest computed tomography on day 8 showed pneumonia and reverse transcription polymerase chain reaction of oropharyngeal swabs showed SARS-CoV-2 infection. 33 However, the causal relationship between GBS and SARS-CoV-2 infection is widely contested because of the low incidence of GBS in COVID-19 patients. 32 According to a study of GBS patients using data from the UK National Immunoglobulin Database, the number of GBS patients treated in UK hospitals rather fell between March and May 2020 compared with the corresponding period of 2016-2019; this was probably due to the influence of lockdown measures that helped reduce the transmission of conventional GBS-inducing pathogens. 12 In another cohort study of GBS patients in the UK (independent of the UK National Immunoglobulin Database) between March and May 2020, 25 of the 47 patients were suspected to be associated with COVID-19. 12 In contrast, a study of patients treated at the emergency departments in Spain during the peak pandemic period (March to April 2020) showed a higher frequency of GBS among COVID-19 patients (0.15%) than in non-COVID-19 patients (0.02%). 11 Another study in Northern Italy suggested an increased incidence of GBS from 0.077/1 000 000/month in the pre-COVID-19 era of March and April 2019 to 0.202/1 000 000/month during the corresponding period of 2020. 13 As in GBS associated with Zika virus infection, electrophysiological features of GBS associated with COVID-19 are usually suggestive of demyelination compatible with those of AIDP. [34] [35] [36] However, some patients with AMAN or acute motor sensory axonal neuropathy have also been reported. 13, 34, 36, 37 According to a systematic literature review from January to June 2020, the mean interval between the onset of COVID-19 and GBS symptoms was 11.5 days. 35 An Italian study compared the clinical features of 30 COVID-19 GBS patients with those of 17 non-COVID-19 GBS patients. COVID-19 GBS patients tended to manifest AIDP, more severe weakness necessitating intensive care unit admission and hypotension. 13 Cerebrospinal fluid parameters were similar in the two groups. 13 Magnetic resonance imaging showed gadolinium enhancement of facial nerves or spinal nerve roots in some of the patients. 38, 39 The treatment strategy for COVID-19 GBS patients is not different from that for non-COVID-19 GBS patients. 13 However, it should be noted that COVID-19 GBS patients tend to be complicated by pneumonia. Even in a study that found no association between GBS and COVID-19, intubation was more frequent in COVID-19 GBS patients (54%) than in non-COVID-19 GBS patients (23%). 12 Although many reports have documented GBS patients associated with Zika virus or SARS-CoV-2 infection, the pathological basis F I G U R E 1 Typical pathological findings of acute inflammatory demyelinating polyneuropathy. A cross-section of a sural nerve biopsy specimen. The cytoplasm of a macrophage invading the basement membrane surrounding a myelinated fiber (arrowheads) contains myelin debris resulting from phagocytosis. The arrow indicates a demyelinated axon. A macrophage located outside of the basement membrane tube of a myelinated fiber is indicated by an asterisk. Uranyl acetate and lead citrate staining. Scale bar, 2 μm. of neuropathy induced by these viruses is not well characterized. The concept of molecular mimicry between pathogens and human peripheral nerve components was established through studies of AMAN-type of GBS following detection of anti-ganglioside GM1 antibodies after Campylobacter jejuni infection. 8 According to this concept, immunoglobulin G autoantibodies directed against surface epitopes of Campylobacter jejuni also react to ganglioside GM1 localized in the axolemma of motor fibers. 8 Consistent with this view, a previous study demonstrated the deposition of immunoglobulin G and complements in the axolemma of motor fibers from AMAN patients. 40 Hence, membrane attack complexes formed by activation of complement cascades resulting from the attachment of autoantibodies cause axonal damage in AMAN. 8, 41 Compared with AMAN, a clear relationship between specific autoantibodies and the occurrence of AIDP, which accounts for most has not yet been shown. 41 The most characteristic pathological feature in AIDP patients is the demyelination resulting from phagocytosis of myelin by macrophages (Figure 1 ). 42 Demyelination in a sural nerve biopsy specimen has also been reported in a patient with Zika virus-associated GBS. 28 A recent study using longitudinal sections of sural nerve biopsy specimens from AIDP patients demonstrated deposition of complement at the sites of macrophage-induced demyelination. 42 A study of autopsy specimens also showed similar findings. 43 These findings indicate that immunological processes mediated by autoantibodies similar to AMAN also play a role in the pathogenetic mechanism of demyelination in AIDP. Polynesia from 2013 to 2014, serum antibodies against glycolipids, including gangliosides, were positive in 13 of 42 patients. 9 In contrast, a more recent extensive investigation of anti-glycolipid antibodies found no specific antibody signature in sera obtained from patients with GBS during the outbreak of Zika virus infection in Northeast Brazil. 44 Nevertheless, mimicry between Zika virus polyproteins and human proteins related to GBS has been reported, 45 suggesting that the peripheral nervous system components other than glycolipids/gangliosides are potential targets of autoantibodies in Zika virus-associated GBS. Molecular mimicry between SARS-CoV-2 and human proteins related to GBS has also been suggested. 46 studies have found an association between GBS and older versions of rabies vaccine prepared from suckling mouse brain and mature sheep brain. 50, 51 However, an extensive review of published literature found only a trivial or no association between currently available vaccines and GBS. 52 Previously suggested links between the oral polio vaccine and diphtheria, tetanus toxoid, and pertussis vaccine have now been excluded, because the risk of development of GBS after inoculation of these vaccines has not been substantiated. 53, 54 In contrast, there are still some concerns pertaining to measles, mumps, and rubella, human papillomavirus, quadrivalent conjugate meningococcal, and influenza vaccines. 55 However, the risk of GBS is not considered a legitimate reason to limit administration of these vaccines, because the benefits far outweigh the risks. 55 Among the vaccines that are reportedly associated with the occurrence of GBS, influenza vaccine is probably the most extensively investigated. Initial reports suggesting the relationship between influenza vaccination and GBS were based on the experience with swine influenza vaccine, which increased the incidence by up to eightfold in 1976 in the USA. 56 In the subsequent studies tion had a lower average risk (incidence density ratio 0.83, 95% CI 0.63-1.08) and a lower cumulative risk (6.6 vs 9.2 cases per million persons, P = 0.012) of GBS than the unvaccinated population. 63 Another study of over 13 million individuals in Canada between 1993 and 2011 provided comprehensive data from this viewpoint. 64 According to that study, the risk of GBS within 6 weeks of influenza vaccination was 52% higher than in the control interval of 9-42 weeks (relative incidence 1.52, 95% CI 1.17-1.99), with the greatest risk during weeks 2-4 after vaccination. 64 In contrast, the risk of GBS within 6 weeks after suffering from influenza was much greater than that associated with influenza vaccination (15.81, 95% CI 10.28-24.32). 64 Additionally, the risk of hospitalization resulting from GBS was 1.03 per million vaccinations, compared with 17.2 per million influenza episodes. 64 An important issue when considering vaccination is whether the overall benefit outweighs the overall risk or not. 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