key: cord-0931550-4mnnwn10
authors: Tummon, Fiona; Arboledas, Lucas Alados; Bonini, Maira; Guinot, Benjamin; Hicke, Martin; Jacob, Christophe; Kendrovski, Vladimir; McCairns, William; Petermann, Eric; Peuch, Vincent‐Henri; Pfaar, Oliver; Sicard, Michaël; Sikoparija, Branko; Clot, Bernard
title: The need for Pan‐European automatic pollen and fungal spore monitoring: A stakeholder workshop position paper
date: 2021-05-02
journal: Clin Transl Allergy
DOI: 10.1002/clt2.12015
sha: 93a987410ae152885ee0d22df85b23585465c3cc
doc_id: 931550
cord_uid: 4mnnwn10

BACKGROUND: Information about airborne pollen concentrations is required by a range of end users, particularly from the health sector who use both observations and forecasts to diagnose and treat allergic patients. Manual methods are the standard for such measurements but, despite the range of pollen taxa that can be identified, these techniques suffer from a range of drawbacks. This includes being available at low temporal resolution (usually daily averages) and with a delay (usually 3–9 days from the measurement). Recent technological developments have made possible automatic pollen measurements, which are available at high temporal resolution and in real time, although currently only scattered in a few locations across Europe. MATERIALS & METHODS: To promote the development of an extensive network across Europe and to ensure that this network will respond to end user needs, a stakeholder workshop was organised under the auspices of the EUMETNET AutoPollen Programme. Participants discussed requirements for the groups they represented, ranging from the need for information at various spatial scales, at high temporal resolution, and for targeted services to be developed. RESULTS: The provision of real‐time information is likely to lead to a notable decrease in the direct and indirect health costs associated with allergy in Europe, currently estimated between €50–150 billion/year.(1) DISCUSSION & CONCLUSION: A European measurement network to meet end user requirements would thus more than pay for itself in terms of potential annual savings and provide significant impetus to research across a range of disciplines from climate science and public health to agriculture and environmental management.

Medical practitioners require information about what is present in the atmosphere and how the situation may evolve to better understand and treat their allergic patients. In response to this need, doctors in countries across the globe established measurement sites to monitor airborne pollen concentrations. As the number of allergy sufferers has grown over the past decades 2,3,4 so have the number of such sites (>500 sites in Europe 5 ; 251 sites in Europe 6 ) and from the mid-1980s onwards many of these sites have been organised into regional and national networks. In parallel, fungal spore monitoring was developed for crop protection purposes (e.g., 7, 8, 9 ) largely at different sites and often carried out by agricultural organisations rather than health-related ones. In many European countries, both the pollen and fungal spore monitoring networks are maintained through scant and inconsistent funding sources and sometimes run by private organisations, which has significant negative consequences in terms of the temporal continuity of monitoring, heterogeneous spatial coverage, as well as the quality and availability of data for public information and research. Indeed, some networks are at the brink of collapse, with financial or political support lacking and volunteerism having its limits.

Pollen and fungal spore measurements have mainly been carried out using Hirst-type volumetric samplers. 10 These impactors collect atmospheric particles on a drum that slowly rotates over the course of several days, usually a week, before it is sent to a lab where it is analysed under the microscope by trained professionals. It is a labourintensive and lengthy manual process which usually provides dailyaverage data with a delay of anywhere between 3 and 10 days. 11 Furthermore, these standardised measurements 12 suffer from a range of errors, including sampling and collection efficiency 13, 14, 15, 16, 17 flowrate estimates 17 or issues related to the manual counts. 18, 19, 20, 21 Overall measurement uncertainty is estimated to be at least 30%. 22, 23 Recently, another weakness of this technique became apparent: as the COVID-19 epidemic shut down countries across the globe, many manual pollen and spore counting sites were unable to continue because personnel were under lockdown. All of this during what was, for the northern hemisphere, the main spring pollen season.

Recent technological developments mean that automatic monitoring of pollen and fungal spores is now a reality. A range of instruments based on different technologies are able to provide data in real-time (i.e., within minutes or a few hours of the measurement) at high temporal resolution (3 h or less). 24, 25, 26, 27, 28, 29, 30, 31, 32 Such developments are transforming the approach to monitoring not only of pollen and fungal spores, but the full capacity of these instruments is just starting to be explored and a much broader range of particles can likely be identified, 28 for example, particulate matter levels. 34 Somewhat similar to what is done for weather forecasts, such high temporal resolution and near real-time observations can be integrated into numerical models to provide improved spatial forecasts. 35, 36, 37, 38, 39, 40, 41, 42 They also represent crucial information for the qualitative and quantitative retrieval of bioaerosols in the atmospheric column, which has recently been achieved using remote sensing techniques. 43, 44, 45, 46 In addition, the same technology can potentially also be used for control of indoor air contaminants, for example in hospitals, food processing chains, and so forth.

Together, these advancements are not only revolutionising the information available to health care practitioners and their patients but also provide a range of opportunities beyond the realm of medicine. For example, improved forecasts of certain fungal spore species could reduce the need for pesticide use in the agricultural sector, decreasing both environmental impacts and associated costs (e.g., 9 ).

The availability of high temporal-resolution observations is also opening up a number of research avenues, for example, to better 2 -

understand the role of pollen and fungal spores in the hydrological cycle (these particles are known to serve as nuclei for cloud and ice droplets) or their role in ecosystem dynamics (see 47 and references therein; 48, 49 ) .

Within this context, the AutoPollen Programme began in 2018 under the umbrella of the European grouping of national meteorological services, EUMETNET. 50 This 5-year programme brings together a wide range of actors from across Europe involved in pollen monitoring, some already with operational automatic monitoring sites (e.g., 51, 52 ) . AutoPollen aims to establish a prototype of a fully automatic pollen monitoring network, develop standards, foster collaboration across Europe and support wide exchange and use of data. This includes covering the entire information chain, from developing measurement protocols and standards, through designing the optimal network, all the way to ensuring the information produced is effectively communicated to meet the wide range of end-user needs. To more fully understand these needs, a workshop bringing together players from a range of stakeholder groups was held. This paper aims to describe the needs of these different end-user groups for real-time pollen and fungal spore information, as well as to outline the infrastructure and services required to meet these needs. 

The most important sector and essentially the original 'raison d'être' for pollen monitoring networks was to provide information to health practitioners treating allergy sufferers. General practitioners, allergologists, pneumologists and clinical immunologists need to know what pollen and fungal spore taxa are present in the atmosphere to diagnose what their patients are exposed to, prescribe the correct medication and evaluate whether any treatment (antiallergic medication or allergen immunotherapy [AIT]) is effective. 53 concentrations. Services providing this information will also be required to educate potential users to this extent.

Just as for many air pollutants, recent studies have shown that for certain pollen taxa, there are marked diurnal cycles at the surface 56 as well as in the atmospheric column 45 and thus when only daily average values are provided, as is currently done in most places, daily peaks are missed. The relationship between diurnal variations in atmospheric pollen and fungal spore concentrations, exposure (related to patient behaviour) and symptoms has to date never been studied at such high temporal resolution. The provision of high temporal resolution automatic observations would finally allow extensive investigations into this issue, potentially leading to better management and treatment of allergy symptoms. Furthermore, the higher temporal resolution data would allow better understanding of the importance of weather and air pollution levels, both cofactors affecting allergic responses. 57, 58, 59, 60 Enhanced understanding of such exposure levels will thus significantly improve the possibilities to develop new therapies. 54 Additionally, several studies have emphasised the occupational and public health risks from bioaerosols emitted from composting facilities, for example, inflammation of the respiratory tract, aspergillosis or allergic and toxic nonallergic asthma. 61 For the health sector, data are needed at various temporal resolutions (see Table 1 ). Allergy sufferers may need information a few times a day, at moments when they change their behaviour, for example, in the morning when planning activities. For these endusers having more measurement sites in space would be more relevant, to ensure that they have information about local conditions. This is also true for medical practitioners and researchers, who in addition also require higher temporal resolution observations to better understand exposure levels and relationships with symptoms. 63 For their purposes, it is thus important that the observational network is comprised of stations that provide information representative of general population exposure at relatively high temporal resolution (several observations per day). Concomitant exposure to airborne pollen, fungal spores and air pollutants can aggravate allergy symptoms. 64, 58, 59, 65, 66 Therefore complementary observations of other air pollutants, such as ozone or particulate matter, should also T A B L E 1 Summary of currently available pollen and fungal spore observations (in blue) and end-user needs for four principle stakeholder communities (in yellow)

Note: Note that for the "Taxa of interest" column, this reflects the current situation in terms of observations (blue rows) and the end-user needs (yellow rows). a Air quality stations must be positioned <4 m above ground due to EU-regulations, whereas pollen monitoring stations should ideally be located at least 10 m above ground. 18, 62 be available to fully communicate overall exposure levels 63 to the public, medical practitioners, and all relevant stakeholders; this is a prerequisite for understanding effects on sensitive individuals. 67 (Table 1) .

Timely measurements will lead to significantly improved forecasts, since these forecasts will be based on actual conditions, and in turn, that the forecasts can also be updated more regularly, as is done for weather forecasts. This would ensure that punctual events, such as large thunderstorms, could be taken into account in forecasts and allow the emission of alerts in real-time. This would potentially help reduce the impact of events such as asthma epidemics associated with massive thunderstorms. 57 Furthermore, these same high temporal resolution measurements are also useful for model validation to assess the accuracy of forecasts compared to actual observations. Pollen and fungal spore forecasts are, like the initial observations, used by a similar range of end-users as outlined in this paper.

During the workshop, participants indicated that they require forecasts at various timescales, from subdaily through to seasonal. Shortterm forecasts, available each 6 h or at moments in the day when people are likely to change their behaviour (morning/midday/evening), would be highly valuable to allergy sufferers. For example, allergic individuals would be able to better plan their daily activities to avoid periods of peak pollen or fungal spore levels, which are known to show diurnal variability (e.g., 56, 71 ) . Accurate forecasts available a few days in advance would also allow allergic individuals to appropriately take preventative medication rather than taking it once symptoms appear. Likewise, accurate forecasts on this timescale would be useful for advising allergic individuals when travelling across Europe. This raises challenges regarding the thresholds to which different populations are sensitive 72 and how to communicate this information; however, further research on this topic is required.

Finally, seasonal forecasts, even information as simple as providing probabilities that the season is expected to be more or less intense than normal, as well as expected start and end dates, would be very valuable to medical practitioners and their patients. Such information would allow patients and their doctors to be better prepared, with patients being able to take allergy medication in a more targeted manner and their doctors to improve how immunotherapies are applied. More precise forecasts of season start and end dates would also be beneficial to the pharmaceutical industry and pharmacies to improve the supply chain management of allergy medication. Such long-term forecasts would also allow advance planning of primary environmental protection measures, for example, in the control of ragweed.

For forecast models, it is particularly important that observational sites are located in source regions so that the simulated emissions can be updated using near real-time observations (see Table 1 ). This is in contrast to the needs of the health sector, which require stations rather to be representative of population exposure and thus closer or even in areas where people live. The influence of emission sources, for both pollen and fungal spores, is highly localised, so it is realistic to imagine a network that is similar to that of the current pollen monitoring network (see 5 ). This would eventually entail 200-300 automatic stations strategically spread across Europe to cover the main bioclimatic zones and emission source regions. In addition to just the airborne concentration values, it is particularly important for forecast models that each measurement is reported with an uncertainty value since this information is vital to be able to properly assimilate observations and to evaluate forecast accuracy.

Fungal spores are common crop pathogens that cause disease and significant economic losses every year. Epidemics of such diseases are known to be associated with wind. 73 In the food storage and processing chain, these species also cause important damages and losses. Estimates from the early 2000s showed that of the annual worldwide food production between 31% and 42% (approximately US$ 500 billion) was lost as a result of diseases, weeds and insects, while an additional 6%-20% (approximately US$ 120 billion) was lost postharvest because of insects and fungal and bacterial rots. 74 Monitoring the spread of fungal spores in real time can help reduce infection rates by allowing early preventive measures to be taken (e.g., 7, 8 ) as well as targeted rather than widespread use of fungicides. Overall, this contributes to a reduction in the amount of TUMMON ET AL. toxic products used, thus also decreasing environmental impacts and associated costs (e.g., 75, 9 collection efficiency). In addition, early detection of the occurrence and spread of airborne plant pathogens may help prevent large-scale epidemics of diseases such as ash dieback. 76 Despite the obvious benefits of having aerobiological data to manage such plant diseases, only few disease control systems utilise airborne fungal spore monitoring, for example, for the control of Venturia inaequalis or Phytophthora infestans. 77 To be useful for plant disease management, aerobiological measurements need to be timely (alerting about the presence of pathogens in real time), specific (able to identify particular pathogens of relevance) and sensitive (able to detect small quantities of spores before the disease can be visually observed). 78 

The high temporal resolution of automatic pollen and fungal spore The availability of high temporal resolution observations and better spatial coverage will also allow significant progress to be made in several other fields, including atmospheric sciences, ecosystem research, understanding the role of pollen and fungal spore particles in the hydrological cycle as well as studies of biogeography and biodiversity. Pollen/spores are present all over the globe and, as any atmospheric aerosol, they scatter and absorb radiation entering the Earth-atmosphere system. For example, in the region of Barcelona, in strong pollen events, pollen can represent up to 30% of the total optical depth. 45 Since present remote sensing technology cannot be used to identify pollen from other aerosols, let alone individual pollen taxa, high temporal resolution surface observations are the only way to link surface and atmospheric column observations. Researchers need high temporal resolution data (see Table 1 ), although not necessarily in real-time, except for specific studies where this may be useful. Importantly, not only are the measurements themselves relevant, but as for forecasts, the uncertainty associated with each observation point is also important. Likewise, multifactorial information is important, that is the provision of meteorological or air quality observations from the same or close-by sites.

In the context of climate change, pollen and fungal spore seasons are expected to become longer, 79,80,81 with higher allergen levels (even if airborne concentrations remain similar), 82 and with faster development of certain fungal species in warmer temperatures. Increased CO 2 concentrations also enable many plants to produce more pollen 83 and increases the allergenicity of pollen. 84 Such changes will have obvious impacts on allergy, human health and agriculture, to name but a few. For example, projections for Europe of the rate of Ragweed sensitisation show that climate change is likely to double the level from 33 million people (1986) (1987) (1988) (1989) (1990) (1991) (1992) (1993) (1994) (1995) (1996) (1997) (1998) (1999) (2000) (2001) (2002) (2003) (2004) (2005) to 77 million by 2041-2060. 58 The availability of high temporal resolution observations as well as better spatial coverage of the network will help better understand the dynamics of invasive species, such as ragweed, by providing information that can be used to understand and identify sources (local or transported) using techniques such as backtrajectories. In this sense, the retrieval of pollen information in the atmospheric column using advanced lidar techniques, 44 Understanding any current or future climate change requires a baseline for comparison and it is thus also important that historical observations, even if manual, are made freely available from across the European continent. This is presently not the case for many observations sites, and there is a risk that these data, particularly the oldest parts of records, are lost. While not the focus of this paper, it is important to point out the significance of these data, together with new automatic observations carried out in the long-term (see Table 1 ), particularly for climate change research and forecast model validation purposes.

To meet the end-user needs outlined above, a comprehensive strategy and integrated infrastructure needs to be put in place (see Figure 1 ). Existent automatic monitoring networks 51,52 as well as those in the development or planning stages are currently collaborating together through the EUMETNET AutoPollen Programme. 50 While this programme is coordinating the nascent network of stations, this will need to be reinforced and further extended to form a 'backbone' network across all of Europe. This network will ultimately require at least 200-300 representative sites strategically located across Europe covering the main bioclimatic zones and providing data that can be used for forecasts at the continental scale. This 'backbone' network will need to be complemented by more dense regional or local networks, which in turn can provide more detailed information, for example, in more populated areas where airborne pollen and fungal spore concentrations have been shown to be heterogeneous in space. 85, 86 While certain regions can afford the initial investment that automatic monitoring entails, others are not yet able to do so. In time, such gaps will need to be filled to ensure that accurate information, both high temporal resolution observations and improved numerical forecasts, can be provided to the entire European population.

The airborne concentration data that these networks produce need to be made available through a common database open for research, numerical forecasts and public use. This will lead to the development of a range of targeted products and services for all enduser groups, whether this be innovative smartphone applications or dedicated informational websites. The whole value chain thus should to be considered (e.g., 87 )-from the initial measurement all the way through its interpretation, model forecasts and to the final services provided to end-users.

While not directly an end-user need, pollen and fungal spore monitoring currently suffers from the challenge of not being a regulatory requirement in most countries, as is the case for most air pollutants for which there are strict monitoring standards and statutes. One of the main reasons for this situation is that pollen and spores are considered 'natural' and therefore controlling their production is thought of as impossible. However, in certain areas this is no longer the case. For example, particularly in densely populated areas, vegetation is often not at all natural; it is either planted (e.g. birch or cypress) or accidentally introduced by anthropogenic F I G U R E 1 Schematic of current and developing automatic pollen and fungal spore monitoring across Europe as well as example end uses TUMMON ET AL.

-7 activities (ragweed being a typical example of this). Thus, the possibility to control and regulate such vegetation and the allergenic pollen it produces is essential. Finally, the continuous increase in the number of allergy sufferers means there is a growing need for the allergy-causing substances to be monitored. The development of regulations to make such monitoring mandatory across Europe would significantly aid the establishment and maintenance of an observational network.

Preparedness of health systems can be strengthened by improving the preparedness of health professionals, which includes providing them with better information and services upon which they can make decisions. This can naturally also be extended to the public who also need to be informed about observed and projected changes in environmental exposure, such as shifting pollen seasons or extension of the geographical distribution of allergenic plant taxa.

A unique window of opportunity exists to establish an automatic pollen and fungal spore monitoring network across Europe in a standardised, collaborative and coherent fashion. It is essential that national and regional efforts to establish observation sites are coordinated, that common measurement protocols are followed and that the real-time information is made freely available in ways that meet end-user's needs. The EUMETNET AutoPollen Programme aims to achieve this through establishing a prototype network across Europe that provides end-to-end solutions for a range of stakeholders. This more operationally oriented programme is being run in parallel and in synergy with ongoing research and development projects, for example, within the Copernicus Atmospheric Monitoring Service or the Cost Action ADOPT (new approaches in detection of pathogens and aeroallergens). Such collaboration is essential to ensure that the potential of current measurement capabilities is fully exploited, for example by extending the number of pollen and fungal spore taxa that can be identified, and that the newest techniques and methods are taken up operationally. This could include complementary measurements of aeroallergens, whose concentrations may vary in each pollen grain or fungal spore 20, or for measurements of indoor biological air quality, where there are a wide range of potential uses to be explored, such as in hospitals or food processing chains.

The long-term sustainability of the European network is vital and ideally should be ensured through engagement from government organisations with stable funding sources and under long-term mandates. Given that the direct and indirect health costs associated with allergy and asthma are estimated to be between €50-150 billion per year in Europe, 1,88 even just a 0.1% decrease in these costs would equate to cost savings of up to €150 million per year. In terms of cost-benefit ratios, the network would thus more than pay for itself. Furthermore, the measurements from the network could be used in a range of other domains such as agriculture, where considerable cost-savings are also possible (e.g., 9 ) or to further a wide spectrum of research in areas such as climate change, public health and environmental management.

Economic burden of inadequate management of allergic diseases in the European Union: a GA2LEN review

Allergy gap between Finnish and Russian Karelia on increase

The epidemic of allergy and asthma

Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. Mechanisms of allergy and clinical immunology

Pollen and spore monitoring in the world

Nilsson S Preliminary inventory of aerobiological monitoring stations in

Alternaria spores in the air across Europe: abundance, seasonality and relationships with climate, meteorology and local environment

Spore traps network: a new tool for predicting epidemics of wheat yellow rust

Predicting soybean rust incursions into the North American continental interior using crop monitoring, spore trapping, and aerobiological modeling

An automatic volumetric spore trap

Pollen monitoring: minimum requirements and reproducibility of analysis

Ambient Air -Sampling and Analysis of Airborne Pollen Grains and Fungal Spores for Networks Related to Allergy -Volumetric Hirst Method

An evaluation of the microscopical counting methods of the tape in Hirst-Burkard pollen and spore trap

Ragweed Pollen: the aeroallergen is spreading in Italy

The effect of changes to the method of estimating the pollen count from aerobiological samples

Sampling in aerobiology. Differences between traverses along the length of the slide in Hirst sporetraps

Errors in determining the flow rate of Hirst-type pollen traps

Near-ground effect of height on pollen exposure

Passports of sampling sites in routine aerobiological monitoring of outdoor air. The trouble with threshold values for allergy forecasts

Pollen counts statistics and its relevance to precision

Precision of the daily pollen count. Identifying sources of variation using variance component models

Statistical understanding of measurement variability of Hirst-type volumetric pollen and spore samplers

Sampling bias and sampling errors in pollen counting in aerobiological monitoring in Italy

Real-time pollen monitoring using digital holography

Building an automatic pollen monitoring network (ePIN): selection of optimal sites by clustering pollen stations

Automatic and online pollen monitoring

Automatic pollen recognition with the rapid-E particle counter: the first-level procedure, experience and next steps

Comparison of fungal spores concentrations measured with wideband integrated bioaerosol sensor and Hirst methodology

Automated pollen monitoring system using laser optics for observing seasonal changes in the concentration of total airborne pollen

All-optical automatic pollen identification: towards an operational system

Pollen exposure weakens innate defense against respiratory viruses

Recent developments in monitoring and modelling airborne pollen, a review

Real-time sensing of bioaerosols: review and current perspectives

Desert dust has a notable impact on aerobiological measurements in Europe

On possibilities of assimilation of near-real-time pollen data by atmospheric composition models

Towards numerical forecasting of long-range air transport of birch pollen: theoretical considerations and a feasibility study

Allergenic pollen: a review of the production, release, distribution and health impacts

Multi-model ensemble simulations of olive pollen distribution in Europe in 2014: current status and outlook

Toward optimized temperature sum parameterizations for forecasting the start of the pollen season

Pollen forecasts in complex topography: two case studies from the Alps using the numerical pollen forecast model COSMO-ART

Numerical simulation of birch pollen dispersion with an operational weather forecast system

Bioaerosols from composting facilities-a review

Airborne pollen observations using a multi-wavelength Raman polarization lidar in Finland: characterization of pure pollen types

Bioaerosol detection over Athens, Greece using the laser induced fluorescence technique

Near-surface and columnar measurements with a micro pulse lidar of atmospheric pollen in

Modelling of airborne pollen dispersion in the atmosphere in the Catalonia region, Spain: model description, emission scheme and evaluation of model performance for the case of Pinus

Bioaerosol field measurements: challenges and perspectives in outdoor studies

Pollen as atmospheric cloud condensation nuclei

Pollen grains are efficient cloud condensation nuclei

The EUMETNET AutoPollen programme: establishing a prototype automatic pollen monitoring network in Europe

An operational robotic pollen monitoring network based on automatic image recognition

RealForAll: real-time system for automatic detection of airborne pollen, Enterprise Inf Syst

Committee for Medicinal Products for Human Use (CHMP): Guideline on the Clinical Development of Products for Specific Immunotherapy for the Treatment of Allergic Diseases (CHMP/ EWP/18504/2006)

Defining pollen exposure times for clinical trials of allergen immunotherapy for pollen-induced rhinoconjunctivitis -an EAACI position paper

Airborne olive pollen counts are not representative of exposure to the major olive allergen Ole e 1

Automatic pollen monitoring: first insights from hourly data

The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors

Climate change and future pollen allergy in Europe

Urban air pollution and climate change as environmental risk factors of respiratory allergy: an update

Alternaria spores in Emilia-Romagna, Northern Italy: current diffusion and trends

Exposures and health outcomes in relation to bioaerosol emissions from composting facilities: a systematic review of occupational and community studies

Spatial and temporal variations in airborne Ambrosia pollen in Europe

Prioritizing research challenges and funding for allergy and asthma and the need for translational research-The European Strategic Forum on Allergic Diseases

Concomitant occurrence of anthropogenic air pollutants, mineral dust and fungal spores during long-distance transport of ragweed pollen

Biology of diesel exhaust effects on respiratory function

Effect of low concentrations of ozone on inhaled allergen responses in asthmatic subjects

Air pollution and climate change effects on allergies in the anthropocene: abundance, interaction, and modification of allergens and adjuvants

Modelación espacio-temporal de polen y esporas de hongos aerovagantes de Catalunya

Atmospheric particulate matter adhesion onto pollen: a review

Study of the Meteorological Mechanisms Controlling Levels and Transport Processes of Airborne Pollen in the Atmosphere (PhD dissertation)

Tageszeitliche Verteilung und langjährige Trends bei allergiekompetenten Pollen

Aerobiological Monographs, Towards a Comprehensive Vision

The ebb and flow of airborne pathogens: monitoring and use in disease management decisions

Status of Research and Application of Crop Biotechnologies in Developing Countries

System for Forecasting Disease Epidemics (SPEC)-decision support system in Polish agriculture, based on aerobiology

The ash dieback invasion of Europe was founded by two genetically divergent individuals

Aerobiology in plant protection

Differentiation of Phytophthora infestans sporangia from other airborne biological particles by flow cytometry

Empol 1.0: a new parameterization of pollen emission in numerical weather prediction models

Recent warming by latitude associated with increased length of ragweed pollen season in central North America

Impacts of climate change on aeroallergens: past and future

The biodiversity hypothesis and allergic disease: world allergy organisation position statement

Environmental behaviour of airborne Amaranthaceae pollen in the southern part of the Iberian Peninsula, and its role in future climate scenarios

WHO Regional Office for Europe. Protecting health in Europe from climate change: 2017 update. WHO Regional Office for Europe

Allergenic pollen production across a large city for common ragweed (Ambrosia artemisiifolia)

Frenz DA Interpreting atmospheric pollen counts for use in clinical allergy: spatial variability

Infras und Bundesamt für Meteorologie und Klimatologie MeteoSchweiz

The need for Pan-European automatic pollen and fungal spore monitoring: A stakeholder workshop position paper

Programme, which is developing a prototype automatic pollen monitoring network in Europe covering all aspects of the information chain from measurements through to communicating information to the public.

The authors declare that there are no conflict of interests.

Fiona Tummon and Bernard Clot wrote the manuscript. All other coauthors contributed to the further development of the text. All authors read and approved the final manuscript.

https://orcid.org/0000-0002-6459-339XVincent-Henri Peuch https://orcid.org/0000-0003-1396-0505