key: cord-0929506-fnkw19xk
authors: Sookaromdee, Pathum; Wiwanitkit, Viroj
title: Seroconversion After Coronavirus Disease 2019 Vaccination
date: 2021-11-25
journal: Liver Transpl
DOI: 10.1002/lt.26327
sha: 72dc7c0bfbf6692d043ca3bf9d3fbca1d2fb4373
doc_id: 929506
cord_uid: fnkw19xk

we would like to correspond on "Seroconversion after COVID-19 vaccination in patients awaiting liver transplant (LT): fact or fancy? [1]." Calleri et al. concluded that "Our data from 89 patients awaiting LT suggest a high rate of immunization (94.4%) after a median time of 23 days from safe mRNA …monitored over time [1]." Regarding patients waiting for LT, the main underlying pathological condition is abnormal liver function.

We would like to comment on the article titled "Seroconversion After Coronavirus Disease 2019 Vaccination in Patients Awaiting Liver Transplantation: Fact or Fancy?" (1) Calleri et al. concluded that "Our data from 89 patients awaiting LT suggest a high rate of immunization (94.4%) after a median time of 23 days from safe mRNA … monitored over time. (1) " Regarding patients waiting for liver transplantation (LT), the main underlying pathological condition is abnormal liver function. The degree of impaired liver function might be associated with immunogenicity after a vaccination. (2) However, there are no data for coronavirus disease 2019 vaccination. The present report by Calleri et al. can confirm the usefulness of vaccination for patients waiting for LT. Indeed, the immunogenicity process related to messenger RNA is directly related to cellular immune responses, not the humoral immune response, which might be affected by impaired liver function. In addition, it is interesting to discuss the diagnostic accuracy of the Liaison (DiaSorin, Saluggia, Italy) SARS-CoV-2 TrimericS IgG assay. The lack of agreement between this assay and other widely used assays has been reported. (3) Discordant results with a neutralization assay are also reported, and they might imply that the identified level of antibody by the LIAISON SARS-CoV-2 TrimericS IgG assay does not directly imply effective immunization or protection against disease. (3) Pathum sookaromdee, Ph.d. 1 Viroj Wiwanitkit, M.d. 2 

Seroconversion after coronavirus disease 2019 vaccination in patients awaiting liver transplantation: fact or fancy?

Immunogenicity of hepatitis A vaccine in decompensated liver disease

TrimericS IgG assay for the detection of circulating antibodies