key: cord-0927658-rrxbswl3
authors: Zagaria, Orlando; Villani, Alessia; Ruggiero, Angelo; Potestio, Luca; Fabbrocini, Gabriella; Gallo, Lucia
title: New‐onset lichen planus arising after COVID‐19 vaccination
date: 2022-02-18
journal: Dermatol Ther
DOI: 10.1111/dth.15374
sha: 4de3d86481a9f186a557562403dcca3343a8ec8a
doc_id: 927658
cord_uid: rrxbswl3

nan

LP is a chronic, autoinflammatory, autoimmune disease with an unknown pathogenesis. 3 In literature, there are several studies reporting lichenoid reactions potentially related to vaccination, particularly against hepatitis B and influenza vaccines. 4 However, there are F I G U R E 1 New-onset lichen planus affecting trunk (A and B), nail (C) and feet (D). RCM images (E) from papules located on the left foot showed the presence of a diffuse inflammatory cells infiltrate (white arrows) composed of brightly refractile, oval to stellate-shaped cells corresponding to melanophages and small, less refractile, roundish cells corresponding to lymphocytes at the dermal-epidermal junction (DEJ) level with focal disruption of dermal papillae that appeared non-rimmed (red circles). RCM, reflectance confocal microscopy few cases of new-onset LP related to COVID-19 vaccination (Table 1) . [5] [6] [7] [8] [9] [10] Clinical trials showed that the vaccination elicits a Thelper 1 (Th1) response, increasing the serum levels of Interleukin 2, Tumor Necrosis Factor-α and Interferon-c. 11 These cytokines may cause new-onset LP development since they are involved also in the pathogenesis of this disease. 11 Several treatments and several diseases changed during COVID-19 pandemic period. 12, 13 To the best of our knowledge, this is the first case of disseminated cutaneous LP with nail involvement. In 

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