key: cord-0926057-ju3vwlow authors: Haroon, Khawaja Hassan; Muhammad, Ahmad; Hussain, Suhail; Patro, Satya Narayana title: COVID-19 Related Cerebrovascular Thromboembolic Complications in Three Young Patients date: 2020-09-28 journal: Case Rep Neurol DOI: 10.1159/000511179 sha: 8a10e1af00575ebfedc8e7d1356aa11fa6981bec doc_id: 926057 cord_uid: ju3vwlow Coronavirus disease 2019 (COVID-19) is a viral illness, caused by the novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). It is currently affecting millions of people worldwide and is associated with coagulopathy, both in the venous and arterial systems. The proposed mechanism being excessive inflammation, platelet activation, endothelial dysfunction, and stasis. As an ongoing pandemic declared by WHO in March 2020, health systems worldwide are experiencing significant challenges with COVID-19-related complications. It has been noticed that patients with COVID-19 are at greater risk of thrombosis. We describe clinical, radiological and laboratory findings of three young patients who presented with ischemic stroke and cerebral venous sinus thrombosis to our hospital within the first few weeks of COVID-19 outbreak. These patients were tested positive for COVID-19 (confirmed by reverse-transcriptase PCR). A 47-year-old Indian man was brought to the emergency department as he was found on the floor with left-sided weakness and a reduced level of consciousness of an unknown time of onset. He had no past medical history. His vitals were stable apart from a respiratory rate of 25/min. His CT of the brain, CT angiogram and CT perfusion ( Fig. 1a -e) showed acute established infarct in the right frontal lobe and basal ganglia, large matched defect in the right MCA territory and occlusion of right CCA and right terminal ICA with no evidence of dissection as well as lung findings suggestive of COVID-19 pneumonia. Considering the unclear time of onset and the already established large infarct, he was deemed unsuitable for acute reperfusion therapies. His COVID-19 PCR was positive. The D-dimer level was 1.23 (0-0.49) and the fibrinogen level was 6.9 (2-4.1). FBC showed Hb 11.1 (13-17) with platelets 531 (150-400); renal functions and electrolytes were all normal; CRP level was 42 (0-5) and ferritin 235 (48-420). He was diagnosed as newly diabetic with HbA1c 13.1 mmol/L. Over the next 24 h, his conscious level deteriorated with further worsening of the focal neurological deficit and homonymous hemianopia. He was transferred to medical ICU for close monitoring and his follow-up non-contrast CT of the head (Fig. 1f ) revealed large right MCA territory infarct. Seven-day cardiac monitoring in medical ICU did not reveal paroxysmal AF. He started to have temperature spikes of up to 39°C on day 4 of admission. He was treated for COVID-19 mild pneumonia as per our protocol and standard treatment for acute ischemic stroke. He was started on aspirin and atorvastatin. A VTE prophylactic dose of enoxaparin 40 mg was given. His ECG and echocardiography were essentially normal with normal thrombophilia screen. On day 10, he was found to have right leg swelling. Doppler US of the leg confirmed proximal right lower limb DVT. Initially, he was treated with treatment dose of LMWH followed by dabigatran 150 mg b.i.d. Later, he was transferred to a rehabilitation facility. A 32-year-old obese man of Cameroonian origin with no past medical history was admitted with a 4-day history of fever, headache, sore throat and dry cough. His temperature was 39°C with a respiratory rate of 16/min, oxygen saturation of 94% on room air and blood pressure of 126/76. Chest X-ray showed lower zone pneumonic consolidation. Nasopharyngeal swab for COVID-19 PCR was positive. He was treated as COVID-19 pneumonia as per our local guidelines. He was given enoxaparin 60 mg for VTE prophylaxis (modified regimen because of obesity as per protocol). As the patient was stable, he was transferred to a community hospital. Thirteen days after COVID-19 symptoms onset, he developed facial weakness with severe dysarthria and right-sided weakness with power 1/5 in the upper limb and 4/5 in the lower limb. He was transferred to a stroke center where the CT of the head, perfusion and angiogram ( Fig. 2a-d) showed early ischemic changes in the left posterior parietal lobe, matched defect in the same area and patent intracranial arteries. Due to delayed presentation and established infarcted area on scans, he was not thrombolyzed. MRI of the head and MRA of the neck ( Fig. 2e -h) revealed multiple infarcts in the left frontoparietal lobe, likely representing embolic etiology and moderate to severe stenosis in the left distal cavernous ICA, respectively. His CRP was 129 (0-5) with normal renal, liver functions, electrolytes, lipid profile and glucose. D-dimer and fibrinogen levels were 0.72 (0-0.49) and 4.8 (2-4.1), respectively. Young stroke screen including thrombophilia screen were negative. His 72-h cardiac monitoring as an inpatient did not show evidence of paroxysmal AF. His ECG was normal with normal TTE and contrast echo study. He was started on aspirin 100 mg, clopidogrel 75 mg, and atorvastatin 40 mg per day. He was managed for COVID-19 as per our local protocol. He had regular rehabilitation and was discharged home with minimal weakness. A 30-year-old Nepalese man was brought to the emergency department as he had occipital headache for 4 days followed by a 2-day history of mild left arm weakness. His weakness got worse in the last 24 h prior to admission. On examination, his left arm power was 3/5 with persistent headache. He also had a mild cough for 3 days. His CT of the head (Fig. 3a) revealed hemorrhagic infarcts in the right high frontal lobe which also raised suspicion of CVST. MRI of the head and MRV (Fig. 3b-h) showed venous infarct in the right high frontal lobe, thrombus in the superior sagittal sinus as well as non-visualization of superior sagittal and right transverse sinuses. His thrombophilia screen, including lupus anti-coagulant and anticardiolipin antibodies, was normal. His nasopharyngeal swab for COVID was positive with normal chest X-ray. His D-dimer level was 1.02 (0-0.49) and CRP level was 19 (0-5) with normal routine labs including lipid profile and glucose. He was initially treated with a treatment dose of LMWH. Later, he was started on rivaroxaban 15 mg b.i.d. for 3 weeks followed by 20 mg daily for 3 months with the plan to repeat MRV in 3 months' time. He was classed as COVID-19 LRTI and was managed as per our local guidelines. SARS-CoV-2 is a single-stranded RNA coronavirus, which enters human cells mainly by binding the angiotensin-converting enzyme 2 [1] , which is highly expressed in lung alveolar cells, cardiac myocytes, the vascular endothelium, and other cells [2, 3] . SARS-CoV-2-mediated disruption and damage to the endothelium may be playing a key role in thrombus formation in patients with COVID-19, as recently, viral particles have been identified in systemic endothelia along with accumulations of inflammatory cells and apoptosis (endotheliitis) [4, 5] . SARS-CoV-2 infection is also linked to a prothrombotic state causing venous and arterial thromboembolism and elevated D-dimer levels [6] . All our patients had standard serological tests and coagulation markers checked at our organization for SARS-CoV-2-positive cases. All three patients had raised D-dimers and CRP. Notably, our first patient had both arterial as well venous thrombosis. All our three patients are young and had negative thrombophilia tests. Patients 1 and 2 did not show evidence of cardiac thromboembolism as echocardiograms were unremarkable and without evidence of patent foramen ovale. Their inpatient cardiac monitoring did not reveal evidence of paroxysmal AF. Our first patient had mild to moderate SARS-CoV-2 infection, while the second and third patients had mild SARS-CoV-2 infection. Interestingly, our first and third patients presented with stroke at the onset of COVID-19 infection while the second patient developed stroke 2 weeks after onset of COVID-19 symptoms, suggesting that COVID-19-associated thromboembolism can occur both early and later in the course of the disease. Recently, three main mechanisms, including hypercoagulopathy, vasculitis and cardiomyopathy leading to stroke in COVID-19 patients, have been described, while the role of various vascular and immune-mediated factors in the pathogenesis of stroke in these patients remain unclear [7] . Our first and second patient showed significant arterial lesions, while the third patient showed a high burden of cerebral venous sinus thrombosis with raised D-dimers and inflammatory markers, leading to stroke. Initial CTA of the second patient did not reveal a vascular lesion, which could be possibly obscured by the surrounding bones and other structures in that particularly tight and small portion of cavernous ICA. His MRA of the neck showed significant disease in that portion of the ICA. Our first patient showed an extensive thrombus in an atypical location emanating from the common carotid artery to the terminal right ICA and the second patient revealed a significant localized intracranial lesion. It remains unclear whether such large lesions are formed at the site or are embolic in nature [7] . As there is no other explanation for such lesions in our previously healthy and young patients, we hypothesize that SARS-CoV-2 possibly led to significant local inflammation and thrombus formation. Though elderly and people with comorbidities such as cardiovascular disease are at higher risk for severe disease, young and otherwise healthy patients are also at risk for complications [8] . All our three patients were previously healthy without known chronic health conditions. Our first patient had T2DM diagnosed during admission. There have been case reports of large vessel arterial thrombosis in mild COVID-19 cases with the youngest being a 33-year-old female [9, 10] . Our second and third patients were 32 and 30 years old, respectively. Our second patient was treated with dual antiplatelets in view of a lesion in the left distal cavernous ICA as intracranial symptomatic disease and continued for 3 months [11] . Though challenging, all our patients were treated with anti-thrombotics and investigated as deemed appropriate by the treating clinicians. Young cases with mild COVID-19 symptoms presenting with major cerebrovascular thrombotic lesions are unusual though evidence in this group is accumulating. Still, there remains uncertainty about the mechanisms and treatment options for stroke in COVID-19 patients. Future clinical trials are warranted to establish the mechanism and to determine the safety and efficacy of these different therapeutic options in patient with SARS-CoV-2 infection. This article was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. The subject in this paper gave their written informed consent to publish their case including publication of images. 3 . a Axial non-contrast CT section of the head shows hemorrhagic infarcts in the right high frontal lobe (white arrows). b, c Axial DWI and ADC map demonstrate venous infarct in the right high frontal lobe (thick white arrow). d Axial FLAIR image reveals patchy hyperintensity in the right high frontal lobe. e Axial SWI image shows prominent cortical veins suggesting venous congestion and gyral microhemorrhage in the right precentral gyrus (white arrowhead). f, g Axial and coronal T1W post contrast images demonstrate thrombus in the superior sagittal sinus (dashed black arrow) and enhancement in the right precentral gyrus (white dashed arrow). h Post contrast MRV 3D reconstruction shows non visualization of the superior sagittal sinus (white arrows) and right transverse sinus (dotted white arrow). 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