key: cord-0925393-2pe45lzf
authors: Berenger, Byron M; Stokes, William; Turnbull, Leeann; Pabbaraju, Kanti; Zelyas, Nathan; Venner, Allison A; Tipples, Graham A
title: Save the COVID-19 point of care nucleic acid test swab after testing to identify variants of concern
date: 2021-10-23
journal: Clin Chem
DOI: 10.1093/clinchem/hvab243
sha: 9d0e2321e6a10e4eec9aa31ce069f68b218fc76a
doc_id: 925393
cord_uid: 2pe45lzf

nan

(VoC), typing has become a critical tool utilized by public health and infection prevention and 33 control for case management. Although POCT has many benefits, one downside is that unless a 34 second swab is collected, no sample is available to the laboratory for further analysis. Using a 35 prospective study design, we determined if the ID NOW swab could be used for confirmatory 36 PCR or variant testing after mixing in the sample receiver to perform the POCT. 37 People with symptoms of COVID-19 or those considered as asymptomatic close contacts to a 38 confirmed case as per Alberta Health guidelines (1) were eligible for POCT ID NOW testing at 39 community collection and test (assessment) centres in the province of Alberta, Canada. Two 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 Fifteen rSwab and NPS samples were not tested by vPCR due to laboratory error. Excluding 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60  Table 1 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 

Ministry of Health, Government of Alberta. Coronavirus, Novel Public Health Disease 109

Development and 112 validation of RT-PCR assays for testing for SARS-CoV-2

Precision response 115 to the rise of the SARS-CoV-2 B.1.1.7 variant of concern by combining novel PCR assays 116 and genome sequencing for rapid variant detection and surveillance