key: cord-0923877-0xsvvhx1 authors: Madsen, Lone Wulff; Lindvig, Susan Olaf; Rasmussen, Line Dahlerup; Knudtzen, Fredrikke Christie; Laursen, Christian B.; Øvrehus, Anne; Nielsen, Stig Lønberg; Johansen, Isik Somuncu title: Low mortality of hospitalised patients with COVID-19 in a tertiary Danish hospital setting date: 2020-10-12 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.10.018 sha: e327f77923d5525b103e5622a386c1be0aa01ad2 doc_id: 923877 cord_uid: 0xsvvhx1 Objectives We aimed to describe clinical characteristics and outcomes of admitted COVID-19 patients in a Danish hospital setting where an early active government intervention was taken. Methods Prospective cohort study including all admitted patients to the COVID-19 unit at Odense University Hospital from March 10 to April 21, 2020. Patients were assessed by a multidisciplinary team at admission. Outcome parameters were development of acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, death and admission time. Results We included 83 patients (median age 62 years, 62.7% male). At hospitalization, 31.3% needed oxygen supplementation and the median National Early Warning Score was four. Median admission time was 7 days (Interquartile ranges (IQR) 3-12). In total, ARDS was diagnosed in 33.7% (28/83) of the patients corresponding to an incidence rate of 7.1 per 100 person days (95% CI: 4.1-10.2). Overall 13 patients (15.7%) were transferred to the ICU of whom 11 (84.6%) received corticosteroids.. No patients died while admitted to the ICU. Four patients (4.8%) died during admission. Conclusion Despite similar patient characteristics compared to those reported by others, we found a low overall mortality of < 5%. The coronavirus disease 2019 (COVID-19) pandemic has caused a major worldwide health crisis and it is essential to learn more about the disease and its management. Publications from the most severely affected regions have demonstrated substantial variation in patient characteristics, disease course, and treatment outcome (Colaneri et al., 2020 , Guan et al., 2020 , Lechien et al., 2020 , Richardson et al., 2020 . The political engagement, socio-demography of affected population and the preparedness of health care facilities of the individual countries appear to affect the course of the pandemic (Docherty et al., 2020 , Grasselli et al., 2020 , Habib, 2020 , Ihle-Hansen et al., 2020 , Israelsen et al., 2020 , Stafford, 2020 , Steffens, 2020 . Organization of the health care system and its capacity seems to play a key role in the management of the patients and treatment outcomes (ECDC, 2020) . The Danish social and health care system is tax funded and provides equal access to free universal healthcare and government sponsored compensation in the event of unemployment or illness. The first Danish case of COVID-19 was reported on February 26, (SSI, 2020c . The initial spread of the infection was believed to be from returning Danish ski tourist from epicenters in Northern Italy and Austria but with-in a few weeks local transmission was evident. On March 11 the Danish government locked down large sections of the Danish society to reduce further spread of the infection. At that time, Denmark had 514 confirmed COVID-19 cases in a country with 5.8 million inhabitants which corresponded to 8.9 cases per 100,000 population (Danmarks Statistik. Population statistics, Office, 2020) . The epidemic in Denmark peaked at the end of March -early April, with the highest number of admitted COVID-19 patients registered on April 1 2020 (9.2 patients per 100,000 population including 2.5 patients per 100,000 population in the intensive care units (ICU)) (SSI, 2020a). After the lockdown, the number of new COVID-19 cases requiring admission has steadily declined leading to the first phase of the re-opening of the society, which was launched on April 15. On May 7, the number of total admitted patients to Danish hospitals was as low as 145 and the second phase of the re-opening of the society was announced (Police, 2020 , SSI, 2020b . So far, there is little information about COVID-19 from countries with a social and health structure comparable to Denmark. The overall aim of this prospective observational cohort study was to report the clinical characteristics and outcome of hospitalized patients with COVID-19 in a tertiary Danish hospital setting, with special focus on patients admitted to the ICU and patients with and without ARDS. In addition, we will report on the model of care for COVID-19 and the capacity with-in our health system. The study was performed at Odense University Hospital (OUH), which serves both as a community-hospital, for app. 500,000 persons and as a tertiary hospital for the Region of Southern Denmark (app. 1.2 million inhabitants)(Danmarks Statistik. Population statistics) . In the beginning of the epidemic all COVID-19 patients, admitted in the Region of Southern Denmark, who were deemed clinically stable for transportation, were transferred to a dedicated corona unit at OUH for further therapy. A substantial number of healthcare personal was trained. The strategy was aimed to provide each COVID-19 unit all necessary basic skills in e.g. lung, heart or neurological disease. This ensured that the allocated staff cared for patients with COVID-19 with co-morbidities within their area of expertise, assisted by Infectious Disease (ID) specialist. Thereby building on existing capacity and forming multidisciplinary teams (MDT). The core members of the team of responsible physicians for the COVID-19 patients comprised ID physicians, pulmonologists, intensive care specialists and nephrologists. A hospital-based prospective cohort study. COVID-19 management was based on local and national guidelines and consisted primarily of supportive therapy (OUH). The indication for steroid treatment was moderate to severe acute respiratory distress syndrome (ARDS) and use of steroids was based on a MDT consensus where standard treatment was dexamethasone 20 mg iv for 5 days followed by 10 mg for a further 5 days. No other therapy was given J o u r n a l P r e -p r o o f unless patients were included in randomized clinical trials (RCTs). Upon admission, each patient was evaluated by a senior consultant and an intensive care specialist to determine whether the patient was a candidate for ICU treatment and/or resuscitation based on the patient`s wishes along with a combination of age, comorbidities or conditions that may limit the potential for future rehabilitation. Based on this evaluation, patients who developed severe respiratory failure or multi-organ failure during admission were either transferred to the ICU or kept on the COVID-19 unit, for further therapy. We included all patients who were 1) 18 years or older, 2) had a positive real time polymerase chain reaction (RT-PCR) analysis for SARS-CoV-2 performed on material from a pharyngeal swab or tracheal secretion indicating COVID-19 disease, and 3) were admitted or transferred to OUH between March 10 -April 21. At end of follow-up for this study (May 1), all patients except one were either dead or discharged. The COVID-19 baseline date was defined as the day of admission for patients presenting with COVID-19 symptoms, or the first date of a positive RT-PCR analysis of SARS-CoV-2 for already hospitalised patients who developed symptoms of COVID-19 during admission. A review of the patients' electronic medical record (EMR) was performed in order to obtain demography-, clinical-, laboratory-, management-and outcome data. Comorbidity was defined as both current and past diseases; for further details see supplemental 1. All triage values (temperature, oxygen saturation with and without supplemental oxygen, blood pressure and heart rate) were registered and based on these values National Early Warning Scores version 2 (NEWS2) were calculated for each patient (Physicians, 2017). Based on the EMR the Eastern Cooperative Oncology Group (ECOG) performance status was derived for each patient (Oken et al., 1982) . All relevant data were registered in a database by one investigator and subsequent checked by a second member of the study team. In case of discrepancy, a consensus was reached through discussion among team members. A complete codebook was predefined for all variables (supplemental 1). All blood samples were registered from the laboratory system to the database. The following clinical defined outcomes were considered: 1) ARDS: The criteria for ARDS and grading of severity of ARDS was based on the fraction of the partial pressure of oxygen (PaO2) to the fraction of inspired oxygen (FiO2) (PaO2/FIO2-ratio) and results of chest imaging as described in current international recommendations (Ferguson et al., 2012 , Griffiths et al., 2019 . 2) ICU admission: Date of transfer to and discharge from the ICU as well as any supportive care given during ICU admission 3) Length of admission to ICU: Total time from transfer to discharge from ICU 4) Length of admission: Discharge from a COVID-19 unit ≤/> 7days Descriptive statistics were reported as proportions for categorical variables and medians with interquartile ranges (IQR) for continuous variables depending on the data distribution. Time was computed from COVID-19 baseline (as previously defined) until date of the outcome of interest or May 1 whichever came first. For all outcomes, the number, proportion and time to the outcome as well as median time was computed. We used Cox regression analyses to compute incidence rates (IR) and 95% confidence intervals (CI). We used cumulative incidence function to illustrate time to first occurrence of ARDS stratified on gender, body mass index ((BMI) 4, less than 5% were hemodynamically unstable at presentation (systolic blood pressure ≤ 90mmHg and/or heart rate >130 bpm). Laboratory and radiological findings at admission are summarized in Table 3 . Notable values with medians outside of normal reference range included lymphocyte count (0.86 x 10 9 /L), C-reactive protein (66 mg/L), Only 11 patients had culture-verified bacterial pneumonia with Haemophilus influenza (n=2), Streptococcus pneumoniae (n=2) and Staphylococcus aureus (n=7). ARDS criteria was met in 33.7% (28/83) of the patients corresponding to an incidence rate of 7.1 per 100 person days. Of these, 25% (7/28) were characterized as severe ARDS. Of the patients transferred to the ICU, 92.3% (12/13) were diagnosed with ARDS, of which it was characterized as severe in 41.7% (5/12). Overall, 75% (21/28) of the patients with ARDS were men. We found no difference in median age between patients with severe ARDS and patients without ARDS. Of patients with ARDS, 57.1% (4/7) received immunosuppressive treatment prior the COVID-19 admission (supplemental 2a). As shown in figure 1, we found a trend towards a higher cumulative incidence for ARDS for male gender, age ≤ 70 years and a BMI ≥ 25; however, this was not statistically significant (rank test > 0.05). We found a moderately positive correlation between admission time and age (Pearson's correlation coefficient r = 0.32, p =0.003). When investigating predictors for ARDS, male sex, BMI ≥25 and prior cardiovascular morbidity it showed a trend towards an increased risk of ARDS in the univariate analyses, but none of the variables deemed statistically significance (supplemental 3). In the multivariate analyze, cardiovascular comorbidity was associated with statistically significant more than 2.6 higher risk of ARDS (supplemental 3). At admission, 81.9% (68/83) were evaluated to be candidates for treatment in the ICU and 13 patients (15.7%) were transferred to the ICU. Median time from hospitalization until ICU admission was 1 day (range 0-10 days) and from onset of symptoms until ICU admission 10 days (range 4-24 days). Almost all patients (92.3%) received mechanical ventilation. Only one patient received noninvasive ventilation at the ICU. The median age was 63 years (IQR 60-69) and the majority was male (76.9%). The average number of comorbidities was 2.5 (range 1-4), the most frequent being hypertension (61.5%) (Supplemental Table 2b ). None of the ICU patients died, and by the end of the study period, all but one patient was discharged from hospital. Antibiotic therapy was prescribed empirically to 69 (83.1%) patients during hospitalization, of whom 74.7% of the patients received broad-spectrum antibiotics (piperacillin-tazobactam, meropenem, cephalosporines, Table 4 ). Steroids were prescribed to 35.7% (10/28) of the patients with ARDS. In total, 8 patients received dexamethasone of which all were admitted to the ICU and diagnosed with either moderate or severe ARDS. In addition 3 patients admitted to ICU received another high dose corticosteroids. Median time of hospital stay until discharge was 7 days (IQR 3-12 days). The patients hospitalized for more than seven days had a higher median age (67 versus 58 years) and had more cardiovascular comorbidities (70.8% versus 34.3% (supplemental table 2c). We found an overall low mortality rate 0.5 per 100 person days (95%CI: 0.2-1.3). The four patients who died (4.8%) during admission had a median age of 83, of whom 75% were men (Supplemental 2d). Cause of mortality was respiratory failure in all cases. The median time of hospital stay until death was 10 days (IQR 6.5-13 days) (Table 4 ). Health system capacity During the study period, neither the regular COVID-19 units nor the ICU were at maximum capacity at any time. In the ICU, patients were cared for by the regular ICU staff at all times. This Danish hospital-based prospective cohort study is among the first to report COVID-19 data from a Scandinavian country where all inhabitants have free and equal access to health care and social support. The general patient characteristics in our study are similar to those reported by others with 17% requiring admission to the ICU (Docherty et al., 2020) and the same proportion of ARDS (Zhou et al., 2020) however, we still found a low overall mortality of 4.8% and a mortality of 0% among patients treated in the ICU. This illustrates the excellent set-up with 1) high preparedness, 2) use of MDT's and 3) the widespread use of dexamethasone for ARDS. These results are from a period in which the Danish government launched an aggressive lockdown of the society to reduce the spread of SARS-CoV-2. As it is apparent from the reduction of COVID-19 admissions during the study period, this lockdown was successful in reducing the number of COVID-19 admissions in Denmark. As a result, our tertiary center never got overwhelmed with severely ill COVID-19 patients. As observed in studies from other countries, the COVID-19 patients in need of hospital admission in this study were predominately male, overweight, middle-aged to elderly with frequent co-morbidities, in particular cardiovascular diseases (Goyal et al., 2020 , Grasselli et al., 2020 , Zhou et al., 2020 . Regarding clinical symptoms, vital signs, and laboratory findings, we found no substantial difference between our results and findings in other studies (Pascarella et al., 2020 , Wang et al., 2020 , but the patient's NEWS2 score appeared to be higher in our cohort (Carr et al., 2020) , however the score is not frequently used in other studies. . ARDS has previously been reported as one of the most frequent causes of deterioration in with reported proportions between 15.6-30.0% (Li and Ma, 2020) . Despite similar proportions of ARDS in our study, an overall low mortality was found among admitted patients when compared to other countries J o u r n a l P r e -p r o o f (Suleyman et al., 2020 , Zhou et al., 2020 . One of the reason for this may be the use of corticosteroids to 84.6% of the ICU patients. A Randomized clinical trial and meta-analysis that since have been published have showed that use of dexamethasone or systemic corticosteroids in general reduce mortality for critically ill patients (Horby et al., 2020 , Sterne et al., 2020 . Our population had a low ECOG performance score at admission. This might be a result of self-isolation of elderly persons and patients with many comorbidities as advised by the government in early March. As such, one could speculate that this could also have contributed to the overall low mortality. Although no statistically significant association between the ECOG score and ARDS was found in the univariate and multivariate regression analyses, these analyses are affected by lack of power. In addition, we found a moderately positive correlation between admission time and age independently of ARDS risk. This could indicate that the inverse relation between age and risk of ARDS was due to an increased admission time among patients with a higher age. The preparedness of each country and the characteristics of the population have shown to be predictors of the overall mortality (Chaudhry et al., 2020) . Results from the same period from another Danish hospital and a large German study, illustrated a mortality of above 20% however, the median age in these cohorts where somewhat higher than ours (Israelsen et al., 2020 , Karagiannidis et al., 2020 . As our institution had comprised a MDT of doctors, all COVID-19 patients were triaged by specialists in ID, respiratory medicine and anesthesiology to ensure that fragile patients were not admitted to the ICU. Furthermore, decision on initiation of steroid treatment for ARDS was based on MDT consultations. However, in this context, it is worthy of note that among those deemed too fragile for the ICU, only four patients died. We speculate that our MDT approach led to a better evaluation and treatment of the patients. . A major strength of this study is that it was performed in a country with free and equal access to health care. All patients experiencing symptoms and signs of COVID-19 infection could be seen quickly by a skilled physician and admitted to hospital if deemed necessary. Therefore, the patients in this study were probably in a better overall condition compared with patients from other settings. Another strength of this study is the MDT approach and the early recognition of the need for development of regional standardized guidelines for the management of COVID-19 patients, which secured best practice treatment. Finally, empirical therapy with antiviral or immunosuppressive drugs were not given outside RCTs. The exception was steroid therapy for ARDS, upon which the decision to treat was based on MDT discussions. The major limitation of this study is the small sample size and single center setting which to some degree may limit its generalizability. Moreover, the low sample size restricted the number of variables that could be included in the regression models in order to avoid an over-fitted model. Furthermore, the low ECOG score and lower median age when compared to other cohorts from comparable studies complicates comparison. This study provides characteristics of Danish hospitalized COVID-19 patients. Despite similar proportions of ARDS in our study, an overall low mortality was found among admitted patients when compared to other countries. This suggest that the preparedness of the society and a timely and well-prepared strategy with an MDT approach to COVID-19 patients along with the use of dexamethasone may improve patient management and short-term prognosis including need of ICU treatment. ISJ conceived the study with input from all co-authors. 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