key: cord-0920709-0i92xqel authors: Rathod, Shrinivas; Dubey, Arbind; Chowdhury, Amitava; Bashir, Bashir; Koul, Rashmi title: A call for new 4R’s based Radiation Oncology model in COVID-19 Pandemic date: 2020-04-25 journal: Adv Radiat Oncol DOI: 10.1016/j.adro.2020.04.013 sha: 2341493d5775ddc5686bd1d110f1cdb074cef1f3 doc_id: 920709 cord_uid: 0i92xqel nan We are in the midst of an unprecedented crisis worldwide. Since its first reports in China on 31 st December 2019, it spread extensively across the globe. As of 4 th April 2020, over 1100,000 cases and over 60000 deaths are reported worldwide. 1 These numbers continue to rise exponentially and the healthcare system is strained to maximum. [15] [16] In these unusual times, the use of reduced fractions/hypofractionation regimens is strongly recommended. Pre COVID19 era, for various reasons, the use of hypofractionated, was highly variable across the world despite supportive data. There is enough data to practice this regimen safely for common cancer sites as prostate, breast, rectum, lung and even palliative situations. 7, 17, 18, 19, 20, 21, 22 The use of hypofractionated and ultra hypofractionated radiation could save potential 10-20 visits, thus lower the risk of infection and even mitigate the risk of treatment breaks and allow the radiation facilities with reduced manpower. With the expected resource and manpower constraints, this model is gaining popularity. 23 A clinical scenario where boost radiation adds minimal benefits to the outcomes is also another potential opportunity to reduce the number of fractions. [24] [25] Judicious resource allocation is paramount and hypofractionation regimens serve a vital purpose. We used this model and proposed thoracic cancer specific provincial consensus. 7 Prostate and breast cancer specific radiation guidelines were recently proposed. 16 ductal carcinoma in situ: Risk of IBTR With RT Delay in DCIS Intervals Longer Than 20 Weeks From Breast-Conserving Surgery to Radiation Therapy Are Associated With Inferior Outcome for Women With Early-Stage Breast Cancer Who Are Not Receiving Chemotherapy Timing of radiotherapy and outcome in patients receiving adjuvant endocrine therapy Duration of androgen suppression before radiotherapy for localized prostate cancer: radiation therapy oncology group randomized clinical trial 9910 Prostate Cancer Radiotherapy Recommendations in Response to COVID-19 Conventional versus hypofractionated highdose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, noninferiority, phase 3 CHHiP trial Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RTPC randomised, non-inferiority, phase 3 trial. The Lancet Acute skin toxicity associated with a 1-week the UK FAST-Forward Trial External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial Quality of Life Outcomes in a Phase 3 Randomized Trial of Optimization of Treatment of Advanced Non-small Cell Lung Cancer Using Radiation Therapy and Chemotherapy: IAEA Multicentric Randomized Phase 3 Study (NCT00864331) Adapting Radiotherapy Treatments for Breast Cancer Patients during the COVID-19 Pandemic: Hypofractionation and Accelerated Partial Breast Irradiation to Address World Health Organization Recommendations. Advances in Radiation Oncology 2020 Association of Radiotherapy Boost for Ductal Carcinoma In Situ With Local Control After Whole-Breast Radiotherapy Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial