key: cord-0920006-l4pcon58
authors: Moktefi, Anissa; Audard, Vincent; El Karoui, Khalil
title: Infections and Collapsing Glomerulopathy
date: 2020-06-26
journal: Am J Kidney Dis
DOI: 10.1053/j.ajkd.2020.05.016
sha: 08ab0baa4be56b538fba2bcd19710926b8ef140a
doc_id: 920006
cord_uid: l4pcon58

nan

To the Editor:

We read with great interest the review of Ahn et al. describing the current diagnosis and management of podocytopathies 1 . As underscored by the authors, the list of underlying processes associated with podocytopathies is growing. Infectious diseases are a major cause of podocytopathies, including collapsing glomerulopathy. We would like to emphasize two pathogens, Plasmodium species and SARS-CoV-2 (the coronavirus causing Coronavirus Disease 19, Covid-19), which could be added to the spectrum of infectious agents associated with collapsing glomerulopathy.

We recently reported clinical and pathological characteristics of 18 patients with collapsing glomerulopathy occurring within three months of an acute malaria episode 2 .

Interestingly, all 7 tested patients had high-risk variants of APOL1. As discussed by Anh These findings suggest that malaria and Covid-19 may be two additional infectious diseases leading to toxic podocytopathies.

Approach to Diagnosis and Management of Primary Glomerular Diseases Due to Podocytopathies in Adults: Core Curriculum 2020

Collapsing Glomerulopathy, and Focal and Segmental Glomerulosclerosis

COVID-19-Associated Collapsing Glomerulopathy: An Emerging Entity

Bomback et al declined to respond