key: cord-0919705-x9icxbop
authors: Pereira, Melvika; Shivdasani, Divya; Roy, Debdip; Rungta, Rachita; Dang, Shreya; Singh, Natasha
title: Post–COVID-19 Unusual Inflammatory Syndromes Detected on (18)F-FDG PET/CT Scan
date: 2022-02-01
journal: Clin Nucl Med
DOI: 10.1097/rlu.0000000000004088
sha: 818ce2cfe7e2af237d3029df8d1256e46f093c29
doc_id: 919705
cord_uid: x9icxbop

SARS-CoV-2 is primarily known to cause respiratory symptoms. However, in this global COVID-19 pandemic, we have come across many extrapulmonary manifestations during and in the immediate post-COVID phase such as gastrointestinal symptoms, kidney and liver injury, myocardial dysfunction and acute coronary syndromes, and neurological, thromboembolic, dermatological, and musculoskeletal disorders. We present 2 such unusual cases of post-COVID complications—diffuse panniculitis and inflammatory myositis, as well as their clinical and FDG PET/CT imaging features.

A 32-year-old man, a week after recovery from COVID-19 (RT-PCR negative), developed multiple small, painful red cutaneous nodules over the bilateral shin and upper limbs associated with high-grade fever (101-102°F), as well as mild swelling along the abdominal wall, which raised suspicion of erythema nodosum. WBCs showed rising trend (10,940/μL). Symptoms showed no relief to antibiotic doxycycline. Blood cultures revealed no growth, with normal chest x-ray. The patient was referred for 18 F-FDG PET/CT scan to evaluate infective focus. PET/CT MIP (A), coronal (B), transaxial fused (C, E, G), and axial CECT images (D, F, H) showed FDG-avid patchy areas of subcutaneous and visceral fat stranding all over the body, appearing inflammatory suggesting diffuse panniculitis. Excisional biopsy from abdominal fat revealed neutrophilic lobular panniculitis. Lobular panniculitis is a neutrophilic infiltration of fat lobules, not associated with vasculitis, and considered an atypical rare subcutaneous variant of Sweet syndrome. 1 It may be idiopathic or associated with hematological malignancies, drugs, systemic disorders, or viral infections, such as SARS-CoV-2 in our case. Excessive cytokine (IL-4, IL-5) production and exaggerated neutrophilic host immune response to COVID-19 infection lead to neutrophilic infiltration in subcutaneous fat. 2,3 Patient showed good symptomatic response to Wysolone 40 mg.

A 57-year-old man, 2 months after recovery from COVID-19 pneumonia, complained of bilateral lower-limb weakness progressively involving bilateral upper limbs, with difficulty in lifting hands over head. No muscular pain nor skin changes observed. Urinary bladder and bowel function were normal. He was on tapering steroids and nintedanib for post-COVID lung fibrosis. Initially steroid-induced myopathy was suspected. 18 F-FDG PET/CT scan was advised to rule out paraneoplastic syndrome. PET/CT MIP (A), coronal (B), sagittal (C), and transaxial fused (D and E) images showed abnormal increased FDG uptake in multiple muscle regions, more intense in the upper-limb muscles, suggesting possibility of inflammatory polymyositis (PM) and changes of interstitial lung disease with septal thickening and bronchiectatic changes in the right lower lobe (axial CT image F). Creatine phosphokinase level was raised (3736 IU/L). Antinuclear and anti-smooth muscle antibodies were negative. Anti-Jo-1 myositis-specific antibody was positive. It is commonly seen in PM associated with viral infections, directed against antihistidyl-tRNA synthetase. 4 Presence of anti-Jo-1 myositis-specific antibody is associated with features of myositis, interstitial lung disease (as seen on our case), 4,5 arthritis, fever, Raynaud phenomena, and mechanic's hand, referred to as antisynthetase syndrome. Electromyography nerve conduction velocity study further confirmed our diagnosis of inflammatory myositis, and biopsy was not performed. Patient was started on mycophenolate mofetil and showed improvement. PM, an autoimmune idiopathic inflammatory myopathy, is triggered by malignancies, drugs, and viral infections 6,7 like SARS-CoV-2 in our case. Proposed immune-mediated mechanism of muscle damage by SARS-CoV-2 is secondary to cytokine storm inflammatory response and cellular protein alteration by virus causing loss of tolerance of selfantigens and autoantibody production. 7, 8 In view of ongoing COVID-19 pandemic, it is important for nuclear medicine physicians to be familiar with presentation and imaging findings of inflammatory syndromes associated with SARS-CoV-2-like myositis and panniculitis on 18 F-FDG PET/CT scan to aid interpretation, diagnosis, and patient care.

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Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience

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Musculoskeletal involvement of COVID-19: review of imaging