key: cord-0918020-3ucxqkse
authors: de Oliveira, Júlia Meller Dias; Butini, Luciana; Pauletto, Patrícia; Lehmkuhl, Karyn Munyk; Stefani, Cristine Miron; Bolan, Michele; Guerra, Eliete; Dick, Bruce; De Luca Canto, Graziela; Massignan, Carla
title: [Image: see text] Mental health effects prevalence in children and adolescents during the COVID‐19 pandemic: A systematic review
date: 2022-03-01
journal: Worldviews Evid Based Nurs
DOI: 10.1111/wvn.12566
sha: cf12254009a81f83ab96e2655d8ed80bfca81cf8
doc_id: 918020
cord_uid: 3ucxqkse

BACKGROUND: The COVID‐19 pandemic health crisis has changed household and school routines leaving children and adolescents without important anchors in life. This, in turn, can influence their mental health, changing their behavioral and psychological conditions. AIMS: To systematically review the literature to answer the question: “What is the worldwide prevalence of mental health effects in children and adolescents during the COVID‐19 pandemic?”. METHODS: Embase, Epistemonikos database, LILACS, PsycINFO, PubMed, Scopus, Web of Science, and World Health Organization Global literature on coronavirus disease were searched. Grey literature was searched on Google Scholar, Grey Literature Report, and Preprint server MedRxiv. Observational studies assessing the prevalence of mental health effects in children and adolescents during the COVID‐19 pandemic were included. Four authors independently collected the information and assessed the risk of bias of the included studies. RESULTS: From a total of 11,925 identified studies, 2873 remained after the removal of the duplicated records. Nineteen studies remained after the final selection process. The proportion of emotional symptoms and behavior changes varied from 5.7% to 68.5%; anxiety 17.6% to 43.7%, depression 6.3% to 71.5%, and stress 7% to 25%. Other outcomes such as the prevalence of post‐traumatic stress disorder (85.5%) and suicidal ideation (29.7% to 31.3%) were also evaluated. LINKING EVIDENCE TO ACTION: Overall findings showed that the proportion of children and adolescents presenting mental health effects during the COVID‐19 pandemic showed a wide variation in different countries. However, there was a trend toward mental health issues. Therefore, policymakers, healthcare planners, youth mental health services, teachers, parents, and researchers need to be prepared to deal with this demand.

COVID-19 is a severe acute respiratory syndrome, caused by a type of coronavirus (SARS-CoV-2), identified in late 2019 in China (World Health Organization, 2020) . Along with all the essential activities that have been restricted, educational institutions such as schools and daycare centers have also been disrupted. One year into the COVID-19 pandemic, over 800 million students still face significant disruptions to their education, ranging from full school closures to reduced or part-time academic schedules (31 and 48 countries, respectively; UNESCO, 2020). School routines have been considered important coping mechanisms for young people with mental health issues. When schools are closed, they lose an anchor in life and their symptoms can relapse (Lee, 2020) .

Although recent studies have shown that COVID-19 infection tends to have milder symptoms in children and adolescents (Nature, 2020) , the most recent data shows an increase of infection in children and more hospitalizations (Delahoy et al., 2021) . Social distancing measures have been taken to prevent educational institutions from becoming a vehicle for the dissemination of this novel coronavirus. The effect of this restriction on children and adolescents' mental health has increased with the prolongation of social isolation, consequently triggering or exacerbating episodes of anxiety, panic, and depression (Jiao et al., 2020; Loades et al., 2020) .

Some studies have also confirmed that changes in emotional and psychological factors can weaken or compromise the immune system (Han & Lee, 2018; Hoven et al., 2005; Jiao et al., 2020; Laor et al., 1997; Park et al., 2020; Plourde et al., 2017) . However, although there are an increasing number of studies on this subject, the prevalence of these mental health effects is not clear for younger populations.

The importance of the results for researchers in this area is very high. It has the potential to guide the pre-existing policies as well as the orientation of new policies to face and combat mental health problems and their consequences. A recent paper recommended that mental health professionals should establish evidence-based guidelines and easy operational strategies to cope with COVID-19 pandemic-related mental health problems in children .

The aim of this study is to answer the research question, "What is the worldwide prevalence of mental health effects in children and adolescents during the COVID-19 pandemic?" The methodology was based on the acronym PECOS, in which participants (P) were healthy children and adolescents up to 18 years old, with no restrictions on gender or ethnicity; Exposure (E) was the COVID-19 pandemic; Control (C) was not applicable; Outcomes (O) were the prevalence of mental health effects during the COVID-19 pandemic; and the type of Studies (S) included were studies with prevalence data for this population, as observational studies (cross-sectional and cohort).

The protocol was registered at the Prospective Register of Systematic Reviews (PROSPERO) under number CRD42020183878.

This systematic review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Checklist (PRISMA; Page et al., 2021) and Synthesis Without Metaanalysis (SWiM) reporting items (Campbell et al., 2020) which has been developed to guide clear reporting in reviews in which alternative synthesis methods to meta-analysis of effect estimates are used.

The search strategy was performed with the assistance of an experienced librarian on October 23, 2020 and updated up to February 1, 2021 in the following databases: Embase, Epistemonikos database, LILACS, PsycINFO, PubMed, Scopus, Web of Science, and World Health Organization Global literature on coronavirus disease. In addition, the grey literature was searched on Google Scholar, Grey Literature Report, and Preprint server MedRxiv. No filters regarding the language and date of publication restrictions were used (Table S1) . A manual search was carried out in the reference list of the included articles and experts were contacted to indicate possible nonincluded articles.

To be included, the study had to present prevalence of possible mental health effects in children and adolescents during COVID-19 pandemic, during the period of social distancing and quarantine or during the period of daily activities resuming. Emotional symptoms, anxiety, depression, stress, post-traumatic stress disorder (PTSD), and suicidal ideation in children and adolescents were considered.

Uncooperative behavior, sadness, worry, helplessness, fear, worry about being infected with coronavirus, worry about death, irritability, and acute stress were also evaluated. In addition, any kind of measurement was accepted, such as questionnaires or diagnoses based on health professional assessments.

Exclusion criteria comprised: (1) Studies conducted in adolescents aged >18 years, without specification of the range age, without separated data about mental health effects in children <18 years old without previous diagnosis of mental health effects; (2) Studies that did not provide quantitative data regarding the prevalence of mental health effects; (3) Studies that presented only secondary data about prevalence of mental health effects; (4) Reviews (literature or rapid reviews), letters, books, conference abstracts, case report, opinion article, technical articles, posters and guidelines; and (5) Studies with duplicated data from another included study.

An electronic manager (EndNote version 9) was used to organize the references. Four reviewers selected the articles independently in two phases after a pilot training test. In phase 1, the titles and abstracts were read, and eligibility criteria applied using online software (Rayyan, Qatar Computing Research Institute). In phase-2, the reviewers read the full-texts, also applying the eligibility criteria. Any divergences were solved by consensus and with the help of a fifth reviewer if there was still incompatibility.

The same four reviewers extracted pertinent data from the selected studies, independently in a pilot-tested form. If data were missing from the article, three contact attempts by electronic mail were tried in a 15-day period to obtain relevant unpublished information.

Next, the extracted data were crosschecked, and their accuracy confirmed in a consensus meeting. In case of disagreement, conflicts were resolved with a final decision by the fifth reviewer.

The included articles were grouped based on the type of outcome. In addition, the included studies were also grouped based on the studies' design and methodological quality.

The methodological quality of the included studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data (Munn et al., 2015) .

Independently, four reviewers evaluated the included studies and all reviewers prior to critical appraisal assessments agreed upon all decisions about the scoring system.

Children and adolescents' emotional, behavioral, and psychological health disorders were considered as the main outcome and the analysis was not restricted by any method for measurement or diagnosis. The extracted data were synthesized in a descriptive manner. Additionally, the quantitative analysis of results was performed based on the primary outcome of prevalence rate of different types of emotional, behavioral, and psychological factors, measured by means of relative or absolute frequencies and their 95% confidence intervals.

Heterogeneity within studies was assessed based on population characteristics, methodological characteristics, and outcome characteristics. Based on preliminary searches, it was expected to find high heterogeneity among included studies, so meta-analysis was considered inappropriate. Therefore, the synthesis of results was also descriptive. Since funnel plots were not feasible, the reported outcomes in the methods and results sections were compared to identify potential reporting bias.

From a total of 11,925 studies identified by the searches of the eight databases, after deduplication, 2873 remained. In the first selection phase, 2794 studies were excluded after title and abstract reading, leaving 78 studies selected to the second phase. After full-text reading, 19 studies were finally included for analysis ( Figure 1 ). Further information about the 59 excluded studies is available in Table S2 .

There were 17 cross-sectional and two cohort studies selected (only cross-sectional data were used to analyze the prevalence data; Gassman-Pines et al., 2020; Zhang et al., 2020) from nine different countries, mostly China. Almost all of them used Internet and social media to access the target population, given the ease with which participants can be contacted during pandemic circumstances. Both parents and children or adolescents answered proxy or self-reported questionnaires. Overall, it was found that more than 35,543 children and adolescents were evaluated given that not all included studies reported sample size. The included studies used different validated instruments to measure mental health effects in children and adolescents. Some studies also evaluated fear (Shorer & Leibovich, 2020) , PTSD during the pandemic (Hou et al., 2020) , and suicidal ideation (Hou et al., 2020; Zhang et al., 2020) . Additionally, some nonvalidated questionnaires were also used in one study to measure uncooperative behavior, sadness, and worry (Gassman-Pines et al., 2020) . The instrument to evaluate worry, helplessness, and fear was not reported in one study (Saurabh & Ranjan, 2020) . Detailed results of individual studies are described in Table S3 .

Among all included studies, no study achieved a complete positive methodological quality tool evaluation in all domains from the Joanna Briggs criteria ( Table 1 ). The domain that presented the highest rate of negative (n = 10) or uncertain (n = 8) judgments was the domain regarding the sampling process, since only one study (Liu et al., 2021) presented a process that did not result in a convenience 

Examination of emotional symptoms and behavior findings found that one American study with children aged 2-7 years disclosed that a minority of them presented with uncooperative behavior (11.5%) and sadness or worry ( A total of 12 studies reported anxiety, including two Chinese national online surveys Zhou, Zhang et al., 2020) .

The prevalence of anxiety varied from 17.6% to 43.7% .

Ten studies reported depression rates. These rates were found to have a high variability between 6.3% from a sample of two Chinese schools, one rural and one urban with children aged 7 to 14 years ; and 71.5% from a rural Chinese high school with adolescents aged below 16 years (Hou et al., 2020) .

Lower stress prevalence was identified in Chinese children and adolescents (7%; Dong et al., 2020) in contrast with 25% in Israeli children (Shorer & Leibovich, 2020 Reporting bias was not detected in the included studies, based on the methods and results evaluations noted above.

The worldwide prevalence of depressive symptoms Zheng et al., 2020) and anxiety Hou et al., 2020) varied greatly between countries and regions. Some included studies evaluated both depression and anxiety among children and adolescents and the prevalence rates also varied considerably Zhou, Yuan et al., 2020) . Explanations for the variability in these findings may be due to extensive variations in the sample sizes, definitions of mental health, tools used to collect data, and the large age-range variations in the included studies. It appears that, according to age group, mental health effects manifestations may differ. We also found considerable variation related to characteristics of the settings, sampling strategy, and sex. Included studies took place with school-based and Internet-based populations. Further, parents and children or adolescents answered the questionnaires in various studies, and girls seemed to be more affected by the mental effects during the pandemic.

Our findings also showed other prevalent mental effects of quarantine, such as worry, helplessness, fear (Saurabh & Ranjan, 2020) , nervousness, agitation, and aggressiveness (Shorer & Leibovich, 2020 ). In addition, some included studies reported negative impacts for child psychological well-being (Gassman-Pines et al., 2020) and

behavioral problems which included emotional symptoms, conduct problems, hyperactivity-inattention, peer problems, and a decrease in prosocial behaviors .

We Another interesting finding was that COVID-19 stress was related to increased loneliness and depressive symptoms, especially for adolescents who spend more time on social media. Furthermore, beyond COVID-19 stress, more time connecting to friends virtually during the pandemic was related to higher depressive symptoms.

Family time and schoolwork were related to less depressive symptoms .

Some studies verified that children's depressive symptoms and anxiety were influenced by gender. Vallejo-Slocker et al. (2020) found that girls scored higher than boys in emotional problems.

Female students suffered greater psychological distress, as well as higher levels of stress, anxiety, and depressive symptoms, during the COVID-19 outbreak in comparison with males . Duan et al. (2020) also reported that total scores of Child Anxiety (SCAS) for females were significantly higher than those of males. Moreover, being female and having poor academic records were associated with severe depressive symptoms and anxiety, suicidal ideation, and suicidal attempts (Hou et al., 2020) . A possible explanation is that females may be more vulnerable to stressful life events. However, a recent study carried out in adults did not find clear gender differences in psychological stress associated with COVID-19 (Cai, 2020) . Regarding the influence of age, no association was detected with respect to anxiety across different age groups . Unfortunately, few studies compared the prevalence rates in different age groups, thus a subgroup analysis was not possible.

By understanding the trend in youth mental health problems during the pandemic, a more effective management for the planning of interventions can be reached. Nowadays, there are programs that aim to address mental health problems in youth that seek for more accessible, affordable, and evidence-based solutions. An example is The Creating Opportunities for Personal Empowerment (COPE; Melnyk, 2020) . It is a cost-effective program that uses the key concepts of Cognitive Behavioral Therapy, and it can be implemented by both mental health providers and nonpsychiatric mental healthcare professionals, like pediatric and family nurse practitioners, pediatricians, family practice physicians, and teachers in primary care and school-based settings (Melnyk, 2020) . E-health interventions for anxiety and depression in children and adolescents have already been employed and may also be an alternative to address the mental health problems in children and adolescents (Thabrew et al., 2018) .

The present systematic review has several strengths. We searched to find the maximum number of eligible studies to minimize bias and to obtain homogeneity by applying appropriate eligibility criteria. Additionally, most of the included studies adopted a representative sample and presented a low risk of bias.

The biggest limitation of this study was that no baseline data were available, which makes it impossible to disentangle the baseline levels of the variables considered from the change associated with the recent circumstances with the COVID-19 pandemic. In a cohort study, Zhang et al. (2020) It is very important to highlight that participant age range varied considerably between studies. Moreover, studies' sample inclusion criteria did not follow rigorous methods or standards. As expected, due to pandemic restrictions, data were collected using online questionnaires, social media, and emails in most studies. As well, another methodological aspect may have influenced our findings. The use of valid measurements and tools, different questionnaires, and self-rating scales for children across studies may have caused conflicting and inconsistent results. We must consider the heterogeneity of the included studies and of the populations of children that were studied. Metaanalysis was not performed due to these methodological heterogeneities. A quantitative analysis combining heterogeneous studies could introduce bias in the results. Finally, most included studies were from China, which may affect the generalizability of results globally.

There was great variability in the worldwide prevalence data for the emotional, behavioral, and psychological health disorders in children 

and adolescents are suffering emotionally at present during this pandemic.

Future studies should use validated measures and try to compare the mental health effects prevalence in youth during and post pandemic periods.

• Evaluating the prevalence of emotional, behavioral, and psychological conditions in children and adolescents during the COVID-19 pandemic is relevant and provides evidence for policymakers, healthcare planners, youth mental health services, teachers, parents, and researchers.

• The present data might help policymakers, healthcare planners, youth mental health services, teachers, parents, and researchers to be prepared to deal with mental health effects of the pandemic in youth. Programs for children's mental health should be implemented.

Furthermore, in addition to screening routinely for these problems,

interventions for prevention and treatment should be encouraged.

• Adequate management of the potentially relevant factors that may be associated with the prevalence of mental health effects can also help to mitigate the problem. Alternatives to hours spent on the Internet such as secure outdoor activities should be encouraged.

The proportion of children presenting with mental health problems during the pandemic varied widely. However, the results demonstrated an overall trend in declining mental health for youth, likely due to the pandemic.

The authors thank Benjamin Oosterhoff, who kindly answered email 

None of the authors have any conflicts of interest to declare.

Carla Massignan https://orcid.org/0000-0001-8033-055X

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