key: cord-0915643-upu5j0h6 authors: García Vicente, Ana María; Soriano Castrejón, Ángel title: Incidental COVID-19 Pneumonia on (18)F-Fluorocholine PET/CT date: 2020-06-08 journal: Clin Nucl Med DOI: 10.1097/rlu.0000000000003189 sha: e9515bd3d4d597c5d5de2496522613cab5575f97 doc_id: 915643 cord_uid: upu5j0h6 We present the case of a patient who underwent (18)F-fluorocholine PET/CT for biochemical recurrence of prostate cancer in which bilateral pneumonia was diagnosed. In the current state of COVID-19 pandemic, a high prevalence of incidental pneumonia may be expected, even with previous clinical triage, explained by a nondefined number of patients who were asymptomatic or minimally symptomatic for infectious process. Therefore, nuclear medicine physicians should be prepared to recognize and diagnose incidental COVID-19 pneumonia manifestation on (18)F-fluorocholine PET/CT, due to the crucial epidemiological implications. A 49-year-old man with diabetes mellitus and prostate cancer (Gleason 6) treated with radical prostatectomy. 18 F-fluorocholine PET/CT was requested for biochemical recurrence (prostate specific antigen of 0.84 ng/mL). No pathological locations related to the oncological disease were observed on 18 F-fluorocholine PET/CT. However, increased metabolism in lung opacities (arrowheads) and some mediastinal lymph nodes (arrows) were observed. Patient was completely asymptomatic at the moment of PET/CT and had only mild cough, 2 weeks ago. Patient was referred to emergency department. Real-time polymerase chain reaction, to detect viral nucleotides from specimens obtained from nasopharyngeal swab, was positive for COVID-19. Based on COVID-19 having pulmonary tropism, pneumonia seems to be very prevalent, up to 56% or 80%, depending on the series. 1, 2 The most discriminating features for COVID-19 pneumonia included a peripheral and lower zone dominance distribution and bilateral involvement (arrowheads). The morphological features are diverse, consisting of ground-glass opacity, reticular pattern, and vascular thickening, among others. 3, 4 Although COVID-19 infections do not seem to be accompanied by lymphadenopathy in terms of nodal enlargement detected on standard CT, 5,6 18 F-FDG and 18 F-fluorocholine can detect lymphadenitis. 7, 8 FIGURE 2 . Chest x-ray (CXR) performed as part of clinical triage in the emergency department was reported as normal. Despite the moderate sensitivity of baseline CXR in the detection of pneumonia, CXR is the first-line triage tool in most European hospitals. 2 Although CXR findings mirror those previously described for CT, the latter is more sensitive in the diagnosis of viral pneumonia especially during the early stages of disease development. 9 Although 18 F-FDG PET/CT plays an important role in evaluating inflammatory and infectious pulmonary diseases, 10,11 18 F-fluorocholine is able to demonstrate the lung inflammatory burden in COVID-19 infection and an important tool in order to take decisions related to epidemiological and clinical recommendations given to patients. 12 Chest radiographic and CT findings of the 2019 novel coronavirus disease (COVID-19): analysis of nine patients treated in Korea Frequency and distribution of chest radiographic findings in COVID-19 positive patients Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review CT imaging features of 2019 novel coronavirus (2019-nCoV) Imaging and clinical features of patients with 2019 novel coronavirus SARSCoV-2 18 F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases Anthracosis mimicking mediastinal lymph node metastases with 18 F-Fcholine in high-risk prostate cancer Sensitivity of chest CT for COVID-19: comparison to RT-PCR PET/CT in non oncological lung diseases: current applications and future perspectives Middle East respiratory syndrome coronavirus: what does a radiologist need to know Incidental CT findings suspicious for COVID-19 associated pneumonia on nuclear medicine exams: recognition and management plan