key: cord-0914906-ei768v4s
authors: Anstey, D. Edmund; Givens, Raymond; Clerkin, Kevin; Fried, Justin; Kalcheva, Nellie; Kumaraiah, Deepa; Masoumi, Amirali; O'Connor, Daniel; Rosner, Gregg F.; Wasson, Lauren; Hammond, Jeffrey; Kirtane, Ajay; Uriel, Nir; Schwartz, Allan; Rabbani, LeRoy; Abdalla, Marwah
title: The cardiac intensive care unit and the cardiac Intensivist during the COVID-19 surge in New York City()
date: 2020-07-03
journal: Am Heart J
DOI: 10.1016/j.ahj.2020.06.018
sha: 4130b291a21043876c0a9ecc146098ec54d54c8d
doc_id: 914906
cord_uid: ei768v4s

Critical care cardiology has been impacted by the coronavirus disease-2019 (COVID-19) pandemic. COVID-19 causes severe acute respiratory distress syndrome, acute kidney injury, as well as several cardiovascular complications including myocarditis, venous thromboembolic disease, cardiogenic shock, and cardiac arrest. The cardiac intensive care unit is rapidly evolving as the need for critical care beds increases. Herein, we describe the changes to the cardiac intensive care unit and the evolving role of critical care cardiologists and other clinicians in the care of these complex patients affected by the COVID-19 pandemic. These include practical recommendations regarding a structural and organizational changes to facilitate care of patients with COVID-19; staffing and personnel changes; and health and safety of personnel. We draw upon our own experiences at NewYork-Presbyterian Columbia University Irving Medical Center to offer insights into the unique challenges facing critical care clinicians and provide recommendations of how to address these challenges during this unprecedented time.

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The Cardiovascular Intensive Care Unit (CICU) was originally designed to take care of patients with mechanical complications and arrhythmias secondary to acute myocardial infarction. In recent decades the pathophysiology of cardiovascular disease has greatly expanded, ushering with it the emergence of the cardiac intensivist. 1, 2 This period has also seen an increase in the number of CICU patients present with primary non-cardiac illnesses but with underlying cardiac disease. 3, 4 In 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease-2019 (COVID-19) was described in Wuhan, China. 5 Rapid spread of this virus has resulted in more than 5,600,000 infections globally, prompting the World Health Organization to classify COVID-19 as a pandemic. 6 As of May 27, 2020, there were more than 197,000 cases of COVID-19 in New York City, and New York State having more cases than most nations around the world. [6] [7] [8] It is estimated that 3-6% of cases will become critically ill, requiring management in a critical care setting. [9] [10] [11] The most common indication for intensive care admission is management of pneumonia or acute respiratory distress syndrome (ARDS).

Many critically ill patients also progress to multisystem organ failure and overall mortality remains high. 11, 12 Cardiovascular complications of COVID-19 have been reported and include myocarditis, stress-induced cardiomyopathy, acute coronary syndromes, arrhythmias, venous thromboembolic disease, and acute cardiogenic shock. [13] [14] [15] In addition to keeping up with rapidly changing national and institutional clinical management and treatment protocols, critical care clinicians must address additional challenges. 16 Finding solutions may require innovative thinking and developing new habits including organizational and structural changes, staffing and personnel changes, and addressing additional concerns regarding staff safety. In this context, the cardiac J o u r n a l P r e -p r o o f 5 intensivist's role will expand beyond the domain of the typical CICU experience. Herein we discuss the evolving role of the cardiac intensivist and changes to the CICU in the era of the COVID-19 pandemic and provide recommendations based on our own experiences at NewYork-Presbyterian Columbia University Irving Medical Center.

Consistent with predictions about the impact of a COVID-19 outbreak on New York City hospitals, hospitals throughout the New York metropolitan area have seen a surge in patient volumes. As patient volume increases within intensive care units, there are unique challenges that must be met so the CICU may rapidly respond to the COVID-19 pandemic. 17 This includes optimization of physical space, attention to available resources, and an increased emphasis on identifying novel strategies to address what was previously routine management. Achieving these goals may involve bedside innovation including but not limited to: re-purposing existing equipment and physical spaces, improved anticipation and planning for clinical decompensation, and in some cases a structural re-design to allow for higher patient volume. The COVID-19 pandemic has provided a unique opportunity for all staff members within the CICU to contribute meaningful and innovative ideas in order to meet the growing and complex needs of these patients. There are several domains across which innovation may occur including the physical layout of the CICU, the timing of laboratory and diagnostic studies, medication administration, clinical monitoring, and the management of cardiac arrests.

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While a typical critical care setting has one patient per room, the response to the surge of critically-ill COVID-19 patients nationally has included repurposing operating rooms and procedural spaces into intensive care units and utilization of single occupancy intensive care unit rooms to accommodate multiple intubated COVID-19 positive patients. [17] [18] [19] Patient rooms within CICUs are utilized both for monitoring as well as a myriad of bedside procedures. Some procedures may be highly aerosolizing including bronchoscopy, intubating, and extubating, among others. Recommendations from the Centers for Disease Control and Prevention 20 suggest that negative pressure rooms be reserved for patients undergoing highly aerosolizing procedures.

Although negative pressure rooms, or airborne infection isolation rooms, are ideal, few institutions are equipped to provide them for all COVID-19 patients. Knowing the ventilation of each patient care area of the CICU and planning to perform aerosolizing procedures in negative pressure rooms can help minimize staff exposure to COVID-19. Further, if a high volume of COVID-19 patients are anticipated, efforts can be made to re-construct rooms to be negative pressure.

COVID-19 Testing in CICU: At our institution, testing for SARS-CoV-2 was performed using a reverse-transcriptase-polymerase-chain-reaction. At the beginning of the pandemic, initial testing for COVID-19 was via the New York Department of Health and results would take up to 24 hours. However, in house testing was rapidly developed. In our lab, results were reported for SARS-CoV-2 in under 12 hours. If a patient's COVID status was unknown at the time of admission to the CICU but COVID-19 was expected, they were designated as a Person Under J o u r n a l P r e -p r o o f 7 Investigation and all protocols and precautions relative to COVID-19 were followed until their status was determined. To be declared COVID-19 negative patients required 2 negative COVID tests. For intubated patients, a tracheal aspirate would additionally be required.

Timing of Lab Testing and Diagnostic Studies: As typical of critically ill patients, patients in an intensive care setting with COVID-19 will require frequent testing as part of their clinical assessment and management. To minimize unnecessary utilization of personal protective equipment (PPE) and reduce exposure risks, when possible the clinical team should standardize times when diagnostic studies, procedures or lab testing will be performed. Input from the entire clinical team, including staff physicians, nurses, CICU technicians, support staff, and respiratory therapists, is essential in formulating optimal times for testing to minimize entry and exit from the patient's room. There is also a risk associated with the transport of laboratory specimens through the hospital. At our institution, as part of daily clinical rounds, timing of scheduled lab draws for the day were discussed with plans to coincide with scheduled medication administration.

Diagnostic Imaging: In the setting of a pandemic, consideration of the benefit of a diagnostic study must be balanced against the risks of obtaining it. These risks include exposure of staff, utilization of PPE, and potential "down-time" of any procedural or diagnostic suite required for adequate decontamination. Such constraints require clinicians to think critically about the expected value of otherwise routinely obtained tests, including echocardiograms, a pulmonary artery catheter, routine electrocardiograms or chest X-rays, and cross-sectional imaging amongst others. When appropriate, a limited or focused study may be sufficient to answer the clinical question. For example, a limited transthoracic echo and/or point-of-care ultrasound, with required views discussed in advance with an echocardiographer, may be sufficient to answer the J o u r n a l P r e -p r o o f 8 clinical question in a critically ill patient and may significantly reduce unnecessary exposure of healthcare personnel to COVID-19. 21, 22 For patients in the prone position, transthoracic echocardiograms protocols for the prone or "swimmer" position should be considered in order to increase the quality of the images obtained and improve the likelihood that the findings may effectively guide clinical management. 23

Timing and Administration of Medications: Similar to lab testing, medication administration is likely to occur frequently throughout the day. The optimal timing of medications should be discussed with the bedside nurse and clinical pharmacist to consolidate medication delivery and potentially to align timing with other therapies such as turning and/or suctioning. The use of extension tubing can further allow nurses to deliver and titrate medications without entering the patient room. This strategy is particularly useful for medications requiring frequent titration including vasoactive agents or sedatives. It is important to note that this would be ineffective for rapid, large volume resuscitation which some patients may require. Extension tubing was used in our CICU rooms including negative pressure rooms. This allowed for medication titration to occur while also maintaining spatial distance.

Alternatives to Common CICU Medications: During a pandemic, national supply chains may be interrupted. Re-evaluation of common CICU medications and their alternatives should be created in conjunction with pharmacists. For example, in the case of sedation for mechanical ventilation, agents such as ketamine or long acting oral agents such as chlordiazepoxide may be used as substitutes for those more commonly used in a CICU. Developing such strategies in advance and in conjunction with clinical pharmacists is ideal.

Telemetry and QTc Monitoring: Many agents used in the CICU for treatment of COVID-19 as well as other concomitant illness have known toxicities including QT interval prolongation. 24 Obtaining a baseline 12-lead ECG is important in determining baseline QTc duration with follow up ECGs after medication initiation to monitor both the QTc duration and for any arrhythmias.

However, to minimize repeated staff exposure to possible COVID-19 and to avoid the need for frequent ECGs, telemetry may be useful to monitor the QTc. This can be both from reading of manual printouts of the telemetry as well as a real-time display of the QTc on the telemetry screen. Although this value may only represent an average of a 3-lead tracing and not a full 12lead ECG, it can provide valuable diagnostic information to determine whether QT prolonging agents can be continued, or if a 12-lead ECG may be warranted.

COVID-19 Related Acute Cardiogenic Shock: Optimizing hemodynamics in the critically ill patient is a routine yet complex challenge within the CICU. The COVID-19 pandemic presents similarly complex patients, many of whom have not only respiratory failure but also shock and multi-organ system dysfunction. While distributive or septic shock appear to be most common, cardiogenic or mixed cardiogenic/septic shock may occur, especially in those with pre-existing baseline cardiac disease 12, 25 Fluid management and titration of vasoactive medications can be particularly challenging in these patients, especially those with concomitant ARDS. 26, 27 Clinicians have to balance the diagnostic information gained from an invasive procedure such as placement of a pulmonary artery catheter for hemodynamic monitoring with the risks of such a procedure to both patient and staff. If pulmonary artery placement is required, we recommend J o u r n a l P r e -p r o o f 10 that highly experienced operators perform the procedure at the bedside when feasible. In lieu of a pulmonary artery catheter, central venous pressure monitoring with a central venous catheter may be useful in assessing hemodynamics including central venous oxygen saturation and determining how to optimize fluid resuscitation and intravascular volume. 28 Further, point of care ultrasonography may take on increased importance in this context for the rapid assessment of the size of the inferior vena cava as a marker of volume status. Additionally, the use of continuous cardiac output monitors may be considered. The approach to acute mechanical circulatory support will need to adapt to unique challenges resulting from COVID-19

disease. The complexity of severe COVID-19 disease with concomitant cardiac failure emphasizes the need for a multidisciplinary team to help guide clinical decisions and management. A multidisciplinary "advanced heart team" consisting of cardiac intensivists, advanced heart failure specialists, acute mechanical circulatory support team and cardiothoracic surgeons is recommended to manage these complex patients in order to decide which mechanical circulatory support device provides optimal hemodynamic support while minimizing the need for patient transportation and personnel exposure to COVID-19. [29] [30] [31] 

There are specific challenges to consider when treating cardiac arrest in a CICU patient with suspected or confirmed COVID-19. 32 The survival and neurologic recovery among patients with COVID-19 who undergo cardiopulmonary resuscitation (CPR) has only been reported amongst patients in Wuhan, China. In that study, among 136 patients with an in-hospital cardiac arrest, only 4 (2.9%) of patients were alive at 30 days. 33 Interim guidance on the management of a cardiac arrest in this population has been recently released by the American Heart Association. 34 Specific areas addressed by these guidelines focus on reducing exposures to health care workers.

Strategies include limiting members entering the room, prioritizing ventilation strategies associated with decreased aerosolization, and carefully considering the appropriateness of initiation and continuation of cardiopulmonary resuscitation (CPR). Strategies employed at our institution to achieve these goals include: 1) Defining team member roles: Team roles are defined proactively at the beginning of clinical shifts. Limiting PPE and room entry only to those who must be at the bedside is an important consideration in order to both preserve equipment as well as maintain safety for all staff. 3) Prone CPR: Proning may be used in the CICU for management of refractory hypoxemic respiratory failure in patients with confirmed or suspected COVID-19. For patients who cannot be placed in the supine position before or during a cardiac arrest, guidelines from the American Heart Association suggest prone CPR may be reasonable. 35 We have previously described one approach to prone CPR which includes positioning a sternal counter-pressure device attached to a standard CPR board beneath the patient. 36 With a firm surface in place, chest compressions can be delivered at the T7-10 vertebral bodies. implemented. To address this, daily code huddles including the code team leaders and cardiac intensivists may be performed to identify code roles, review policy changes, and to discuss prior code experiences for collective learning.

In the CICU it is essential to have effective communication between the staff on clinical service and hospital leadership. Much of the existing communication infrastructure at CUIMC was leveraged in order to adapt to needs specific to the COVID-19 pandemic (Figure 1) . For housestaff teams, prior to the beginning of each new rotation, the housestaff met with leadership from the Division to address expectations and updated CICU protocols during the COVID-19

pandemic. There are also multiple nursing specific meetings to discuss acute changes occurring in the CICU, anticipate challenges, and provide an opportunity for staff feedback. These include a CICU nurses "AM huddle" before each change of shift and nursing divisional meetings three 

To account for higher patient volume, medical teams may need to be restructured so as to allow for expanded team sizes. The goal of such expansion in the CICU is to adapt standard staffing and resources to increase patient capacity without impacting patient care. There are multiple J o u r n a l P r e -p r o o f 14 ways to achieve this which will be specific to each institution. At our institution, we have attempted strategies involving splitting teams into smaller units and flattening the staffing pyramid so that only essential team members are physically on rounds. This also allows for social distancing within the unit. Specifically, at CUIMC, 10 of our 28 CICU beds had the capacity to have 2 patients in one room. These rooms were reconfigured to allow for 2 patients per room and increase the total CICU capacity to 38 beds. Care teams were divided to have 2 teams of 10 patients and 2 teams of 9 patients. In the final rounding model, each team consisted of 1 cardiac intensivist as the attending of record, 3 NPs or residents, and 1 fellow for each team on weekdays and 1 fellow per 2 teams on weekends. Routine physical examinations are limited to one team member per day to minimize PPE use and potential exposure to COVID-19. Further examinations occurred as necessary throughout the day if it was anticipated to result in an acute change in management. To adapt to both the clinical and emotional demands of managing patients with COVID-19, 37 the typical service model was changed to 1 week on followed by 1 week off service. With this approach, the CICU is able to manage a greater volume of patients, and cardiac intensivists were not redeployed to other care areas. The CICU nurse-to-patient ratio is 1:2 (for patients not on mechanical support) with nurses trained in critical care. When the hospital was at peak capacity, an alternate care model helped to meet the increased volume by having a non-critical care nurse supporting a CICU nurse, with a CICU nurse-to-patient ratio of 1:3. Alternative staffing models utilized in other locations throughout the NewYork-Presbyterian system have been previously described. 19 Any intensivist who is not deployed is considered to be part of the deployable pool for the CICU if a provider was not be able to work due to being quarantined or if he/she became ill. by COVID-19 that may involve high mortality and risk to staff must assume heightened responsibility for assessing, supporting and potentially replacing team members who exhibit signs of emotional distress. At our institution, wellness support resources for all employees including peer support groups are readily available. In addition, weekly debriefing sessions with the cardiac intensivist, advanced care providers, and nurses are done in order to review challenging cases and to address well-being issues with staff. Situation monitoring also requires team members' awareness of patient status; ongoing assessment of their own and each other's needs, strength and limitations; monitoring the environment for safety and resource availability; and communication to promote a "shared mental model." Mutual support requires teamwork to provide assistance and support with tasks, assertive advocacy for patients, delivery of respectful J o u r n a l P r e -p r o o f 16 but timely and goal-oriented feedback, and conflict resolution. Ideally, a CICU team will be familiar with CRM concepts before a crisis occurs. However, leaders of teams with insufficient training in CRM may still employ techniques like TeamSTEPPS while educating staff and clinicians about the need for process improvement.

In addition to having a firm understanding of critical care cardiology, critical care clinicians must adapt to the changing CICU environment by expanding their skillsets to include tele-education, supply/chain management, and telehealth. Given the increase in patient volume, an expansion of the usual team to include clinicians from other disciplines outside of cardiology is to be expected. As these new clinicians may need to provide care outside of their usual scope of practice, fast on-boarding and education of these clinicians who may not usually practice within a CICU setting will be necessary. At CUIMC centralization of multidisciplinary educational resources including training videos, webinars, and tele-education are performed and disseminated on a daily and/or weekly basis. The cardiac intensivist and staff also serve as a consultative resource throughout the hospital to other clinicians given the clinical expertise of the CICU in the management of critically ill patients with cardiovascular complications of COVID-19. [13] [14] [15] Further, cardiac intensivists should participate in supply/chain management decisions in conjunction with administrators and leadership. Lastly, to decrease transmission risk, many hospitals now limit and/or restrict visitation of family members especially within critical care settings. Therefore, reliance on telehealth within the CICU setting is essential in order to provide comprehensive daily updates with respect to patient care progress that can replace the daily "bedside family meeting." This includes conducting tele-palliative care sessions with family members and healthcare proxies to discuss code status and goals of care. When faced with J o u r n a l P r e -p r o o f challenging ethical issues or conflicts, 39 an ethics consultation should be performed to guide the primary team's decision. At our institution, we have also emphasized utilizing our partnerships with palliative care and engaging in early goals of care discussions with patients and family. For patients who are not intubated and can participate in family meetings, providing a tablet or mobile phone at bedside for patients to be able to communicate directly with family members should be considered.

It is imperative to ensure reduction of infectious threat to team members. As further discussed below, when possible, COVID-19 positive patients should be placed in airborne infection isolation rooms (negative-pressure rooms). 20 Consistent with guidance from the Centers for Disease Control and Prevention, all staff must be educated in the proper donning and doffing of PPE. 40 Frequent handwashing, including before and after all patient contact, must be enforced. A unit "champion" may be designated to periodically assess staff adherence to infection prevention protocols and ensure that donning and doffing is performed properly. Only essential team members should be present in a patient's room during cardiac resuscitations or during aerosolgenerating procedures and members must not be allowed to enter the patient room before being appropriately covered with PPE. 34

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