key: cord-0914225-u1npw7tw
authors: Lagunas‐Rangel, Francisco Alejandro
title: Neutrophil‐to‐lymphocyte ratio and lymphocyte‐to‐C‐reactive protein ratio in patients with severe coronavirus disease 2019 (COVID‐19): A meta‐analysis
date: 2020-04-08
journal: J Med Virol
DOI: 10.1002/jmv.25819
sha: 1e106b95bd1cc3a6b2dd74eb9cc55d715081756e
doc_id: 914225
cord_uid: u1npw7tw

Since March 11, 2020, the World Health Organization (WHO) defined Coronavirus disease 2019 (COVID-19) as a pandemic, with a series of confirmed cases that currently exceeded 300,000 people worldwide and with approximately 14,500 deaths. Accumulated evidence suggests that a subgroup of patients with severe COVID-19 could have a dysregulation of the immune response that allows the development of viral hyperinflammation. Thus, all patients with severe COVID-19 should be screened for hyperinflammation using laboratory parameters in order to improve mortality. Neutrophil-to-Lymphocyte ratio (NLR) and Lymphocyte-to-C-reactive protein ratio (LCR) are established inflammation markers that reflect systemic inflammatory response, and both are available in almost all laboratories. In this study, a meta-analysis was performed to investigate whether NLR and LCR values can help predict clinical severity in patients with COVID-19. This article is protected by copyright. All rights reserved.

Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis Despite several reports describing increased levels of neutrophils and C-reactive protein along with a decrease in lymphocyte numbers in patients with COVID-19, 2,6-10 until now, very few reports have considered the cost-effective markers NLR and LCR to aid complication predictions. Acute respiratory distress syndrome, which is a type of respiratory failure characterized by a rapid onset of generalized inflammation in the lungs, is the leading cause of mortality of patients with COVID-19. Thus, increased NLR levels and low LCR levels reflecting an enhanced inflammatory process may suggest a poor prognosis.

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