key: cord-0912105-fcjst3x4
authors: Peres, Gabriel; Miot, Hélio A.
title: Erythema gyratum repens following COVID‐19 infection
date: 2021-08-08
journal: Int J Dermatol
DOI: 10.1111/ijd.15838
sha: 1d725d1c6c1181268b250ac41232a2333a74a5f3
doc_id: 912105
cord_uid: fcjst3x4

nan

on clinical findings, supported by histologic findings. 1 Though EGR has been originally reported as a paraneoplastic syndrome, 2 in up to 20-30% of cases, it is associated with nonneoplastic causes, of which 1% are related to infection. 3 We report on a 71-year-old previously healthy (non-smoking) male with the sudden onset of inferior limb pain and paresthesia followed by progressive itchy, erythematous, annular, The patient refused computed tomography of the chest, abdomen, and pelvis. A colonoscopy only resulted in histopathologically proven benign polyps. There is a rationale on the immune responses triggered by the malignancy, such as (I) cross-reactivity of tumor antigens, (II) transformation of normal skin proteins into antigenic, and (III) deposition of immune complexes at the basement membrane. 9 The pathophysiology of COVID-19, summarized above, resembles the potential EGR mechanisms I and III.

In this case, the complete spontaneous resolution of EGR and the polyneuropathy suggest it is related to a late inflammatory COVID-19 manifestation of a post-acute COVID-19 syndrome. 8 

Erythema gyratum repens: a paraneoplastic eruption

Erythema gyratum repens; skin manifestations in patient with carcinoma of breast

Erythema gyratum repens is not an obligate paraneoplastic disease: a systematic review of the literature and personal experience

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection

Self-reported cutaneous manifestations in 1,429 Brazilian COVID-19 patients

Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases

Unraveling the mystery of Covid-19 cytokine storm: from skin to organ systems

Post-acute COVID-19 syndrome

Erythema gyratum repens associated with cryptogenic organizing pneumonia

Erythema gyratum repens: a pathogenetic mystery and therapeutic challenge

Funding source: None. doi: 10.1111/ijd.15838