key: cord-0906786-s13jplt0
authors: Wendlandt, Blair; Ceppe, Agathe; Gaynes, Bradley N.; Cox, Christopher E.; Hanson, Laura C.; Nelson, Judith E.; Carson, Shannon S.
title: Posttraumatic Stress Disorder Symptom Clusters in Surrogate Decision Makers of Patients Experiencing Chronic Critical Illness
date: 2022-03-01
journal: Crit Care Explor
DOI: 10.1097/cce.0000000000000647
sha: c7007b7bd22d750777422e13db5c051abb627575
doc_id: 906786
cord_uid: s13jplt0

Symptoms of posttraumatic stress disorder (PTSD) are common among surrogate decision makers of patients with chronic critical illness (CCI). PTSD symptoms can be categorized into clusters including intrusion, avoidance, and hyperarousal, each of which has been associated with distinct outcomes and treatment responses. Our objective was to determine which symptom cluster was predominant among surrogates of patients with CCI. DESIGN: Secondary analysis of data from a clinical trial of a communication intervention. SETTING: The original trial was conducted in medical intensive care units at three tertiary-care centers and one community hospital. PATIENTS: Patients with CCI (≥7 d of mechanical ventilation and not expected to die or to be weaned from the ventilator in the subsequent 72 hr) and their surrogates. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Surrogate PTSD symptoms were measured 90 days after onset of patient CCI using the Impact of Events Scale-Revised (IES-R). The IES-R includes a total score (range, 0–88, higher scores indicate severe symptoms) as well as three subscales that assess intrusion, avoidance, and hyperarousal (range of intrusion and avoidance scores 0–32 and range of hyperarousal score 0–24). Intrusion symptoms were most severe (mean score, 10.3; 95% CI, 9.3–11.2), followed by avoidance (mean score, 8.0; 95% CI, 7.2–8.8). Hyperarousal symptoms were lowest (mean score, 5.1; 95% CI, 4.5–5.7). In a multivariable linear regression model, we found that surrogates of patients who died had higher odds of intrusion (β, 5.52; p < 0.0001) and avoidance (β, 3.29; p = 0.001) symptoms than surrogates of patients who lived, even after adjusting for baseline symptoms of anxiety and depression. Patient death was not associated with hyperarousal symptoms. CONCLUSIONS: Intrusive thoughts are the most severe PTSD symptom in surrogates of patients experiencing CCI, with intensified symptoms among surrogates of patients who died. These results have the potential to inform tailored treatment strategies to reduce PTSD symptoms in this population.

experience significant symptoms of PTSD within the first few days of a loved one's ICU admission, and that 6 months later as many as 35% of surrogates report persistent, significant PTSD symptoms (6, 7) . Risk factors for surrogates' PTSD symptoms include patient death as well as their own age and sex, higher levels of anxiety and depression at the time of ICU admission, and perception of inadequate emotional support and communication from healthcare workers in the ICU (8) (9) (10) . Poor patient outcomes and greater caregiving burden are predictive of higher levels of psychological distress and worse quality of life for family caregivers, who often act as surrogate decision makers (11) (12) (13) (14) (15) .

Although interventions to reduce surrogate PTSD have the potential to benefit both patients and surrogates, interventions to date have been largely unsuccessful (16) (17) (18) (19) (20) (21) . One potential reason for this is that these interventions have been targeted to surrogates based on patient condition (such as severity of illness or number of days on the ventilator) rather than tailored for surrogates' own experiences with a loved one's illness and symptom profile.

According to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition), symptoms of PTSD can be categorized into distinct clusters including intrusive thoughts or reexperiencing of the traumatic event (intrusion), persistent avoidance of stimuli associated with the traumatic event (avoidance), and persistent symptoms of increased arousal such as anger or irritability (hyperarousal) (22) . Although individuals with PTSD will generally display symptoms from each cluster, the relative severity of each cluster often differs between individuals (23) (24) (25) . Research has shown that distinct PTSD symptom clusters can be associated with specific outcomes (26, 27) . For example, in a cohort of combat veterans in the U.S. military, avoidant symptoms were associated with higher rates of alcohol abuse than intrusion or hyperarousal symptoms (28) . Furthermore, it has been shown that PTSD symptom cluster can inform personalized treatment strategies for PTSD (29) . For example, individuals that display intrusion-predominant symptoms may be more responsive to particular classes of pharmacotherapy such as selective serotonin reuptake inhibitors (SSRIs), whereas individuals who display more severe hyperarousal symptoms may be more responsive to cognitive behavioral therapy (30) .

The relative contribution of each PTSD cluster to overall symptom burden has not previously been described in medical ICU surrogate decision makers. To better characterize risk for adverse future outcomes and to inform the development of tailored interventions to reduce surrogate distress, we sought to identify the predominance of different PTSD symptom clusters among ICU surrogates. We hypothesized that hyperarousal would be the predominant symptom cluster displayed by ICU surrogate decision makers, with more severe symptoms among surrogates who experienced patient death than those who did not, given that many of the key hyperarousal symptoms (hypervigilance, sleep disturbance, and anger) have previously been described by families of critically ill patients (31, 32) .

We conducted a secondary analysis of data from a randomized trial of a communication intervention for surrogate decision makers of patients experiencing chronic critical illness (CCI) (16) . The intervention consisted of a series of palliative care-led meetings with enrolled surrogates that were protocolized to focus primarily on patient prognosis. The intervention was compared with a control group of usual care with family meetings led by ICU clinicians without the protocolized communication template. Adult patients were eligible for inclusion in the original clinical trial if they had received mechanical ventilation for at least 7 days and were unlikely to die or to be liberated in the next 72 hours. Requiring mechanical ventilation for at least 7 days is a widely used criteria for the definition of prolonged mechanical ventilation, which is in turn one of the accepted diagnoses used to define CCI (33, 34) . Patients with major trauma, burns, or neuromuscular weakness were excluded, as were patients with prior palliative care consultation or ICU admission during the research hospitalization. For each patient, a primary surrogate decision maker was enrolled as designated by either patient choice or applicable state law. If one or more additional surrogate decision makers were involved, these individuals were enrolled as well. Enrollment generally occurred on or around day 10 of mechanical ventilation, at which time baseline patient and surrogate characteristics were assessed. All enrolled patients and surrogates with complete 90-day follow-up data were included in our secondary analysis.

Surrogate psychological distress symptoms were measured at the time of enrollment using the Hospital Anxiety and Depression Scale (HADS) Score (35) . The HADS consists of two subscales (anxiety and depression), each containing seven items with a score ranging from 0 (lowest level of symptoms) to 3 (highest level of symptoms). A score greater than or equal to 11 on either subscale suggests the presence of anxiety and/or depression disorder(s); scores from 8 to 10 may represent "borderline" symptom levels. Patient level of alertness was measured once at the time of trial enrollment by a trained research coordinator using the Richmond Agitation Sedation Scale (RASS) score (36) . For this analysis, the RASS score was categorized as greater than or equal to 0 (awake), -1 to -3 (arousable), and -4 or -5 (unresponsive). Patient chronic comorbidities, including history of cancer, liver disease, end-stage renal disease, and stroke, were obtained via chart abstraction at the time of enrollment. Patient and surrogate outcomes, including patient death and surrogate PTSD symptoms, were then measured 90 days after trial enrollment.

Surrogates' PTSD symptoms were assessed using the Impact of Events Scale-Revised (IES-R), a core outcome measure for assessing PTSD symptoms following ICU admission among patients and their family members (37) . The IES-R contains 22 items that measure symptom clusters of intrusion, avoidance, and hyperarousal over the last 7 days (Fig. 1) (38, 39) . Item scores range from 0 (least distressing) to 4 (most distressing), with a total score ranging from 0 to 88, with the intrusion and avoidance subscores ranging from 0 to 32 each and the hyperarousal score ranging from 0 to 24. The Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 splits the avoidance cluster into separate "avoidance" and "negative alterations in cognition and moods" clusters, between which the IES-R does not distinguish, but this change was made well after the clinical trial began (22) .

For analyses, descriptive statistics were first performed using means and 95% confidence intervals for continuous variables and percentages for categorical variables. We determined the mean total IES-R score as well as symptoms cluster scores at 90 days. To assess whether the risk for each symptom cluster differed between surrogates of patients who died and surrogates of patients who survived, we performed three separate multiple linear regression models, each with patient death by 90 days as the exposure and surrogate PTSD symptom cluster score as the outcome. Covariates were selected based on prior literature and mechanistic plausibility using a directed acyclic graph, which is the recommended method for guiding studies of causal inference in critical care research (40, 41) . The selected covariates were patient age, surrogate symptoms of anxiety and depression at time of trial enrollment, patient history of cancer, patient history of chronic liver disease, and patient level of arousal as measured by the RASS score (directed acyclic graph shown in Supplemental Figure 1 , http://links. lww.com/CCX/A938). The model was adjusted for multiple respondents, using a mixed model, considering the patients as a random factor. All tests were two-sided, with a significance level of 0.05. Analysis was performed using Statistical Analysis System 9.4 (SAS Institute, Cary, NC). This work was approved by the University of North Carolina Institutional Review Board (10-1692). History of liver disease, n (%) 29 (13) History of cancer, n (%) 53 (24) History of stroke, n (%) 20 (9) History of end-stage renal disease, n (%) 9 (4)

Presence of advance directive at enrollment, n (%) 31 (14) 1-yr mortality as predicted by ProVent score, mean % (95% CI) 62 (58.6-64.8)

Richmond Agitation Sedation Scale at enrollment, n (%) -5 or -4 (unresponsive) 95 (44) -3 to -1 (arousable) 81 (38) ≥ 0 (awake) 38 (18) Acute renal failure requiring renal replacement therapy, n (%) 48 (19) Tracheostomy, n (%) 139 (54) Duration of mechanical ventilation after randomization, mean (95% CI), d 20. The mean total IES-R score at 90 days for surrogates was 23.3 (95% CI, 21.3-25.4). A total of 91 (30%) of 306 surrogates had an IES-R score greater than or equal to 33, suggestive of a probable diagnosis of PTSD. The intrusion PTSD cluster had the highest mean subscale score (10.3; 95% CI, 9.3-11.2), followed by avoidance (8.0; 95% CI, 7.2-8.8) and hyperarousal (5.1; 95% CI, 4.5-5.7). Compared with surrogates whose loved one survived, we found that surrogates of patients who died had higher mean intrusion (13.2 vs 8.3; p < 0.0001) and avoidance (9.8 vs 6.8, p = 0.0009) subscale scores. Hyperarousal symptoms were similarly low for both groups (5.7 vs 4.7; p = 0.13) (Fig. 2) . Differences in intrusion and avoidance symptoms persisted even after adjusting for the clinically important covariates shown in Table 3 . Surrogates of patients who died also had higher odds of experiencing both intrusion symptoms (beta coefficient, 5.52; p < 0.0001) and avoidance symptoms (beta coefficient, 3.29; p = 0.001) at 90 days (Table 3 ).

We found that 30% of surrogate decision makers of patients with CCI experienced symptoms suggestive of a diagnosis of PTSD and that intrusion and avoidance symptoms of PTSD were more severe than hyperarousal symptoms. We also found that surrogates who experienced the death of a family member reported higher levels of intrusion and avoidance symptoms than surrogates who did not experience a family member's death. These findings were contrary to our hypothesis that hyperarousal symptoms would be most severe and provide insight into the future of traumainformed care for this population.

The finding that one in three surrogate decision makers experience PTSD symptoms has compelling implications for clinical care, since critical care teams treat patients but have no formal role in diagnosing and treating conditions that are being experienced by family members. With future research, investigators may discover ways of supporting these decision makers during CCI that mitigate subsequent PTSD symptoms. Alternatively, healthcare systems and reimbursement policy may require reforms to support outreach and psychological services triggered by the role of surrogate decision maker for someone with CCI.

Considered to be the "classic" symptoms of PTSD (30), intrusion symptoms involve reexperiencing of the traumatic event and can include recurrent and involuntary memories, nightmares, flashbacks, intense or prolonged psychological distress in response to reminders of the traumatic event, or intense physiological reactions to reminders of the event (22) . In other surrogate populations, intrusion symptoms are theorized to be driven by frequent encounters with and reminders of a particular traumatic event (42) . Because patients experiencing CCI experience long hospital stays, persistently high severity of illness, and frequent encounters with the healthcare system following hospital discharge, their surrogate decision makers may be especially prone to reexperiencing and intrusive thoughts (43, 44) . Furthermore, development of intrusion symptoms has been associated with a particularly strong fear response to a traumatic event (45, 46) . Fear is a common emotional response described by surrogate decision makers following a patient's ICU stay (32, 47) , with uncertainty about the future, seeing a loved one become severely ill, and the potential for major life change as a result of the ICU stay all as items that are particularly fear-inducing (47) . Although the predominance of PTSD symptom clusters among surrogate decision makers of patients experiencing CCI has not previously been described, such clusters have been described in surrogates of those with an acute critical illness and provide findings consistent with ours. One study conducted among surrogate decision makers of patients admitted to a neurointensive care unit with acute brain injury found that intrusion symptoms were most prominent among surrogates, and that lower patient Glasgow Coma Scale score at the time of admission was associated with increased symptoms across all three clusters (48) . Intrusion symptoms can be especially detrimental to psychological well-being, mood adjustment, and coping (2, 49, 50) , offering a potential clue as to why the development of effective emotional support strategies has been challenging in these populations (51, 52) . Our finding that surrogate decision makers experience high levels of intrusion symptoms can be used to inform future support interventions that are more specifically targeted to this cluster type. (30) . Group-based interventions can play a role in the reduction of intrusion symptoms (53) , which is promising for the growing field of peer support interventions for ICU recovery (54) . Additionally, group-based interventions to reduce PTSD can be effectively delivered via telehealth, offering potential for use throughout the COVID-19 pandemic and for surrogates with limited capacity for in-person treatment due to patient care responsibilities or other obligations (55, 56) . If pharmacotherapy is required, SSRIs are recommended as first-line treatment for individuals with intrusion-predominant symptoms (30) .

Additionally, we found that although mean symptom cluster scores were higher among surrogates of patients who experienced patient death than surrogates who did not, the pattern of PTSD cluster predominance (highest mean intrusion symptoms and lowest mean hyperarousal symptoms) was the same between the two groups. Many experts suggest that the predominant PTSD symptom cluster can be used to inform treatment approach even in individuals who have "subthreshold" PTSD symptoms or symptoms that do not exceed the threshold for a formal diagnosis of PTSD (30, 57) . As such, our finding that indicates that there is potential for a single-treatment approach could provide benefit for both groups.

Although the mean score for avoidance symptoms was slightly lower than that for intrusion symptoms in our cohort at 90 days, this finding still merits attention as avoidance symptoms are associated with many negative effects including reduced self-confidence, self-efficacy, and quality of life (58) . This is notable as reductions in family self-efficacy have been associated with worse patient health outcomes, such as increased emergency department visits, in other disease processes such as dementia (15) . Avoidant symptoms are associated with a desire to avoid triggers that remind the affected individual of the initial trauma, which ultimately leads to inadequate processing of trauma and hinders recovery (49) . Furthermore, prior studies have shown that avoidance and intrusion symptoms can become more strongly intercorrelated over time, potentially posing even greater long-term risk to surrogates of CCI patients (2) . In terms of treatment approach, cognitive behavioral therapy holds promise for reduction in these symptoms especially among individuals with severe PTSD symptoms prior to treatment (53, 59) . Finally, although hyperarousal symptoms such as anger or irritability are often easier for clinicians to identify, they were less severe in the population we studied. This further reinforces the need for use of validated instruments to screen for surrogates who are at high risk for distress as opposed to relying solely on clinician judgment or intuition. Prior research indicates that high PTSD symptoms within the first 48 hours of patient ICU admission are predictive of high PTSD symptoms 6 months later for surrogate decision makers (60) . Administration of the IES-R to all ICU surrogates upon patient ICU admission, with attention toward not only total score but predominant symptom cluster, could facilitate early identification of high-risk surrogates and subsequent guidance toward tailored treatment.

Strengths of our study include the relatively unexplored research question among a broad range of medical and surgical critical care conditions, large sample size, and the high 90-day retention/data capture rate (84% of surrogates with complete 90-d follow-up information). In addition, we were able to control for baseline anxiety and depression symptoms in our analyses using the HADS instrument. Last, our study population was drawn from both large academic medical centers and a smaller community center across multiple geographic regions, thus increasing generalizability of our findings.

Our study also has limitations. First, following the initiation of the clinical trial from which our data were derived, the DSM was revised to expand the requisite symptom clusters for the diagnosis of PTSD to include emotional numbing-a cluster not assessed by the ICU outcomes core measure IES-R-in addition to intrusion, avoidance, and hyperarousal. Second, it is possible that surrogates lost to follow up from the original trial and thus underrepresented in our analyses were more highly distressed and, in particular, more likely to have suffered from avoidant symptoms. Third, participants were enrolled into the original clinical trial based on designation as the patient's surrogate decision maker. Many of them were family caregivers, but it is not known whether findings are generalizable to family caregivers who are not also responsible for surrogate decision making. Finally, this study was conducted among surrogate decision makers of patients experiencing CCI and may not be representative of PTSD symptoms in other populations of surrogate decision makers including surrogates for patients experiencing only acute critical illness.

We found that intrusive thoughts are the most severe type of PTSD symptom among surrogate decision makers of patients with CCI, with more severe symptoms among surrogates of patients who died. These findings may be important in informing the development of personalized treatment strategies designed to reduce psychological distress among ICU surrogate decision makers.

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The authors have disclosed that they do not have any potential conflicts of interest.For information regarding this article, E-mail: blair.wendlandt@ unchealth.unc.edu