key: cord-0906671-t2nx9hti
authors: Sakamoto, Takahiro; Kagawa, Yuzo; Endo, Akihiro; Tanabe, Kazuaki
title: Intense Emotional Stress Over Potential Coronavirus Disease Vaccination Side Effects Leads to Takotsubo Cardiomyopathy
date: 2021-07-10
journal: Circulation Reports
DOI: 10.1253/circrep.cr-21-0075
sha: 6ef98cd4c23102a1257165694fe2489adfbee3a8
doc_id: 906671
cord_uid: t2nx9hti

nan

Takahiro Sakamoto, MD; Yuzo Kagawa, MD; Akihiro Endo, MD, PhD; Kazuaki Tanabe, MD, PhD 

and concern about COVID-19 vaccine side effects. In Japan, many patients are concerned about vaccine side effects, and it may be necessary to pay attention to a possible increase in TCM cases in the future. 

This study was approved by the Shimane University Faculty of Medicine Ethics Committee (Reference no. 5588).

Takotsubo cardiomyopathy caused by intense emotional stress induced by voluntary quarantine during the coronavirus disease crisis

T akotsubo cardiomyopathy (TCM) is often triggered by intense emotional stress. Here we report a case of TCM induced by stress due to concerns about side effects after being vaccinated for coronavirus disease (COVID)-19.A 64-year-old woman received COVID-19 vaccines on April 26 and May 17, 2021, and no post-vaccination side effects were noted. However, her anxiety grew as she regularly heard about the potential side effects of the COVID-19 vaccine on various media platforms. On May 27, she presented to Shimane University Hospital with severe chest pain. The electrocardiogram showed negative T waves (Figure A) with positive troponin I. Mild congestion was observed on radiography (Figure B) , and echocardiography revealed left ventricular apical akinesia and basal hyperkinesia. Emergency coronary angiography showed no significant stenosis (Figure C) , whereas left ventriculography demonstrated apical ballooning (Figure D; Supplementary  Movie) . The left ventricular wall motion improved without any medical treatment. The patient was discharged on Day 10 without any complications.TCM caused by intense emotional stress from voluntary quarantine during the COVID-19 crisis has been reported; 1 however, this is the first report on TCM triggered by stress