key: cord-0905180-hm0ovsq4 authors: Alimohamadi, Yousef; Sepandi, Mojtaba; Rashti, Roya; Nezhad, Homeira Sedighi; Afrashteh, Sima title: COVID-19: Clinical features, case fatality, and the effect of symptoms on mortality in hospitalized cases in Iran date: 2022-05-10 journal: J Taibah Univ Med Sci DOI: 10.1016/j.jtumed.2022.04.010 sha: c439e1f603c0ec6d96b870e7051c824b9fb242ea doc_id: 905180 cord_uid: hm0ovsq4 OBJECTIVE: Identifying the epidemiological characteristics of COVID-19 could help to control the pandemic. The aim of this study was to characterize the epidemiological features of hospitalized COVID-19 patients in Iran. METHODS: Data were collected on patients admitted to a military referral hospital in Tehran, Iran, from February 8, 2020 to July 28, 2021. Gender, age, clinical symptoms, outcome, type of comorbidities, level of blood Spo(2), time of admission, and time of discharge were investigated. Sex ratio, case fatality rate (CFR), and daily trends of hospital admissions and deaths were also determined. Descriptive statistics and multiple logistic regression with 95% confidence intervals were used for data analysis. The statistical significance level was set at 0.05. STATA16.0 and Excel 2010 were used for data analysis. RESULTS: The median hospital length of stay (LOS) was 6 days. The following symptoms were most common: cough (63.5%), fever (50%), respiratory distress (46.1%), and muscular pain (40.8%). Hypertension (29.5%), diabetes (24.7%), and cardiovascular diseases (21.8%) were the most prevalent comorbidities. The CFR was calculated at 8.30%. Respiratory symptoms increased the odds of death by 45% (OR 1.45, 95% CI 1.03–2.06). Gastrointestinal symptoms were associated with a reduction in the mortality of COVID-19 cases, but this association was not statistically significant (OR 0.94, 95% CI 0.73–1.21). CONCLUSIONS: The results of this study emphasize higher mortality rates among older age groups, male patients, and patients with underlying diseases. : Methods: Data were collected on patients admitted to a military referral hospital in Tehran, Iran, from February 8, 2020 to July 28, 2021. Gender, age, clinical symptoms, outcome, type of comorbidities, level of blood SpO 2 , time of admission, and time of discharge were investigated. Sex Q7 ratio, case fatality rate (CFR), and daily trends of hospital admissions and deaths were also determined. Descriptive statistics and multiple logistic regression with 95% confidence intervals were used for data analysis. The statistical significance level was set at 0.05. STATA16.0 and Excel 2010 were used for data analysis. Results: The median hospital length of stay (LOS) was 6 days. The following symptoms were most common: cough (63.5%), fever (50%), respiratory distress (46.1%), and muscular pain (40.8%). Hypertension (29.5%), diabetes (24.7%), and cardiovascular diseases (21.8%) were the most prevalent comorbidities. The CFR was calculated at 8.30%. Respiratory symptoms increased the odds of death by 45% (OR 1.45, 95% CI 1.03e2.06). Gastrointestinal symptoms were associated with a reduction in the mortality 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 Introduction In 2019, SARS-CoV-2, a highly contagious and novel coronavirus was identified where each infected case infected an average of three other people. 1,2 As of September 26, 2021, 5,519,728 patients with COVID-19 have been identified in Iran, of which 119,082 deaths have been attributed to the virus. According to statistics, Iran ranks eighth in the world in deaths due to The virus is transmitted through droplets from the nose when coughing and sneezing. Common symptoms of COVID-19 include fever, dry cough, and fatigue. 4 There may be other symptoms such as muscular pain, loss of smell and taste, sore throat, and headache. Shortness of breath and chest pain are among the more serious symptoms of the disease. Vaccination, social distancing, hand hygiene, and face masks are among the common measures to contain the pandemic. 5 The clinical manifestation of the disease is often mild and the disease is usually self-limited. However, COVID-19 is a serious risk to the elderly and to people with underlying diseases such as cardiovascular disease, diabetes, cancer, and chronic lung disease. 6, 7 The epidemiological features of hospitalized COVID-19 patients in Iran have been previously reported. 8 Our study was based on data from February 8, 2020 to July 28, 2021 and aimed to characterize the clinical features, case fatality, and effect of symptoms on mortality among hospitalized cases of COVID-19 in Iran. Here, we report the results of an epidemiological analysis of all cases hospitalized at a military referral hospital in Tehran, Iran. This retrospective epidemiological study was performed on hospitalized patients with COVID-19 at a military hospital in Tehran from February 8, 2020 to July 28, 2021. All data were kept confidential. The disease was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) using throat and nose swab specimens from the upper respiratory tract or clinically diagnosed based on lung imaging features (chest computed tomography scan ground glass pathognomonic). The study variables were as follows: gender, age, clinical symptoms, outcome (including death or survival), types of comorbidities, level of blood SpO 2 , time of admission, and time of discharge. Descriptive results were expressed as the mean (AE standard deviation, SD), median (with an interquartile range, IQR ¼ Q 1 À Q 3 ), or number (%). The missing data were not imputed. The sex ratio (male to female) and the case fatality rate (CFR) were calculated. Odds ratios (ORs) based on multiple logistic regression with 95% confidence intervals (CIs) were calculated. The statistical significance level was set at 0.05. STATA version 16.0 and Excel version 2010 were used for data analysis. All of the cases (3759) were approved by chest CT scan, and 1016 (27%) of cases were PCR negative. The mean age of the patients was 57.48 AE 17.27 years, and the median age was 59 (70e45) years. Most of the cases were in the age group of 61e70 years (819, 21.78%). According to hospital records, the hospital readmission rate was about 0.004 or 4 cases per 1000 hospitalized cases. The median (interquartile range) time from discharge to hospital readmission in these cases was 9 (24e3) days. Also, most cases (2147, 57.1%) were male. The male-tofemale ratio was 1.33:1.0. The mean hospital length of stay (LOS) was 7.18 AE 6.22 days and the median LOS was 6 (8e 4) days. Figures 1 and 2 More information about the baseline clinical information is shown in Table 1 . The most common symptoms in hospitalized cases were cough (63.5%), fever (50%), respiratory distress (46.1%), and muscular pain (40.8%) ( Table 2 ). The most prevalent comorbidities among COVID-19 cases were hypertension (29.5%), diabetes (24.7%), and coronary heart diseases (21.8%) ( Table 2) . During the study period, 313 deaths occurred, so the overall CFR among hospitalized cases was 8.30%. Patients over 80 years of age had the highest CFR among the age groups (25.56%). The CFR for men and women (Table 3) . The results of multiple logistic regression showed that respiratory symptoms significantly increased the odds of death by 45% (OR 1.45, 95% CI 1.03e2.06). Also, gastrointestinal symptoms were associated with a reduction in mortality of COVID-19 cases but this association was not statistically significant (OR 0.94, 95% CI 0.73e 1.21). Having other symptoms (fever, headache, dizziness, etc.) was significantly associated with a reduction in mortality of COVID-19 cases (OR 0.57, 95% CI 0.44e0.73) ( Table 4 ). The present study aimed to describe the epidemiology, clinical features, case fatality, and effect of symptoms on mortality and hospitalized cases. In this study, the CFR of COVID-19 was higher in men than women and the highest CFR was in people over 80 years (25.25%). A meta-analysis by Biswas et al. showed that male gender and age above 50 years were associated with an increased risk of mortality. 9 Many studies have Q1 shown higher mortality in males compared to females. 10e12 One explanation may be related to the role of genes. The angiotensin-converting enzyme (ACE2) gene plays a key role in the virus entering the cell, which is located on the X chromosome and can play a different role in women who are heterozygous than in homozygous men. 13 Other studies showed a higher CFR among older patients, and age has been suggested as a risk factor for death among ICU patients. 14, 15 According to the Korea Center for Disease Control and Prevention, 10.9% of deaths were observed in people aged 70e79 years and 26.6% were in people over 80 years old. 11 In Italy, the highest CFR was observed in people aged 70e 79 years and over 80 years old (16.9% and 24.4%, respectively). 12 In fact, the severity of the disease and the higher CFR at older ages may not be directly related to age but rather due to the greater prevalence of chronic diseases in these people, who subsequently have weaker immune systems. 16, 17 In the present study, the mean age of patients was 57 years and most of the cases were seen in the age group of 60e70 years. This may indicate a lower risk of hospitalization among young people, which is consistent with other studies. 8, 18 In this study, cough and fever were the most common symptoms in hospitalized patients. In the study of Moon et al., the mean age of patients was 56 years. Cough and fever were the most common symptoms among hospitalized patients. 19 In a study by Lee et al., in South Korea , no severe cases of the disease were observed in people under 19 years of age, and cough was the most common symptom among hospitalized patients (59%). 20 Old age has also been reported as one of the risk factors of severe acute respiratory syndrome (SARS) which, as mentioned above, could be due to the high prevalence of chronic diseases in these patients. 21 The CFR is estimated at approximately 2% among cases of SARS-CoV-2 worldwide. This index varies from 0.9% in Turkey to 18.7% in Yemen, and it is 2.2% in Iran. 22 The CFR is higher in hospitalized patients compared to the general population. Our study showed that the CFR in hospitalized patients was 8.5%, about four times that of the general population. The CFR in hospitalized patients may depend on several factors, such as the virulence of SARS-CoV-2, population vulnerability (age and sex), the quality of the healthcare system, the definition of morbidity and mortality, and the accuracy of data recording. Thus, it is perhaps illogical to compare this index among different countries or locations. 23 In the present study, the admission of patients to the ICU was 14.8% and ICU patients had the highest CFR (52.6%). In a meta-analysis study by Zhang et al., ICU admission was 10.9%, 24 similar to our results. In other studies, ICU admission has been reported to be about 10%. 25 Some biochemical factors such as leukocyte count, alanine aminotransferase, aspartate transaminase, high lactate dehydrogenase (LDH), and elevated procalcitonin had been reported to be associated with increased ICU admission and patient mortality. Re-infection with COVID-19 could be due to several reasons: time has passed for the virus-neutralizing antibody, the type of sample collection and technical errors associated with the test, methods used before discharge, and the presence of viral RNA in the stool. 26 In our study, the proportion of hospital re-admission was 0.5%. This low rate may indicate temporary protection against the virus after infection. Due to the possibility of mutation in the virus, however, it is necessary to apply protective and preventive functions during and after recovery. Comorbidity due to decreased immune system function and polypharmacy can cause severe disease. 27 In the present study, the highest CFR was in renal (23%), cancer (21.6%), heart disease (15.49%), hypertension (11.63%), and diabetes (11.39%) patients. In a meta-analysis study, kidney disease ranked first and cardiovascular diseases ranked third in mortality. 14 The association between higher mortality and comorbidities has also been reported in other studies. 28, 29 SARS-CoV-2 virus enters cells via the ACE2 receptor, an enzyme found in the heart, lungs, brain, and kidneys in abundance. This is probably the reason for the increased severity of SARS-CoV-2 in kidney, heart, and lung patients. 30, 31 On the other hand, this study showed the highest CFR in people who had respiratory symptoms and other symptoms such as fever and headache. We found that respiratory symptoms increased the odds of mortality by 45%. In a meta-analysis study performed on cohort studies comparing two groupsdpatients admitted to the ICU and patients not admitted to the ICUdamong the symptoms, fever and shortness of breath showed a significant relationship with the severity of the disease and admission to the ICU, and patients admitted to the ICU had higher mortality rates and lower discharge rates. 32 The present study had a relatively large sample size (3759). However, one of the limitations of the study pertains to hospital data. The data in the current study had not been collected for research purposes and were often incomplete or illegible. Moreover, para-clinical variables and treatment procedures are among the main factors predicting the severity of the disease, 24 and these were not considered in our study. The results of this study emphasize the higher mortality rate among older age groups, male patients, and patients with underlying diseases. Our results further indicate the importance of paying attention to the symptoms (especially respiratory symptoms) of patients upon arrival at the hospital. As SARS-CoV-2 continues to mutate, the pathogenicity and other epidemiological indicators of the disease can change, and this warrants close investigation. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector Q8 . The authors have no conflict of interest to declare. Effect of COVID-19 in hospitalized cases 5 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 Ethical approval This study was approved by the ethical committee of AJA University of Medical Sciences. (IR.AJAUMS.REC.1399.065). Data records were anonymous, so informed consent was waived. YA and MS conducted the search, data analysis, and manuscript preparation. RR, HSN, and SA helped prepare the manuscript and its English edition. All authors have critically reviewed and approved the final draft and are responsible for the content and similarity index of the manuscript.. 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