key: cord-0904647-75ukjg9n
authors: Nogues, Xavier; Quesada-Gómez, José Manuel; Garcia-Giralt, Natalia
title: Response to Letter to the Editor from Viola Viola: “Calcifediol treatment and COVID-19-related outcomes”
date: 2021-07-31
journal: J Clin Endocrinol Metab
DOI: 10.1210/clinem/dgab566
sha: 61e4321b91780121d8ca82696c8fc6524b604da4
doc_id: 904647
cord_uid: 75ukjg9n

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A c c e p t e d M a n u s c r i p t Disclosure Statement: XN has received fees from lectures and consultancy from Amgen, UCB, and

Lilly. JMQG has received small lecture or consultancy fees from Amgen and Faes Farma (Spain).

NGG has nothing to declare.

We thank Dr. Viola and colleagues for their letter to our article (1) . We agree with the authors' point that 25(OH)D levels should be assayed during the hospital stay and even after discharge.

Unfortunately, because of the harsh working conditions during the first wave of the pandemic, data were obtained in only a few patients. However, a rapid rise in 25(OH)D levels was expected after acute oral calcifediol intake, according to previous studies (2) , and was confirmed in in-house controls (data not shown). Vitamin D's role in immune response mechanisms appears to be regulated primarily Hence, treatment with calcifediol at higher doses is recommended to prevent worse COVID-19 outcomes as an adjuvant therapy in the hospital. Anyhow, further studies in an RCT setting are being carried out to corroborate this calcifediol effect.

Overall, there is well-establish agreement that an adequate vitamin D status is necessary to maintain both musculoskeletal and general health (4, 5) , thus regular monitoring of 25(OH)D levels should be considered at the population level and, in particular, in osteoporotic patients and the elderly.

Accordingly, calcifediol or vitamin D supplementation should be strongly recommended to maintain adequate serum 25(OH)D levels in the general population.

Letter to the Editor from Viola Viola: "Calcifediol treatment and COVID-19-related outcomes

Is calcifediol better than cholecalciferol for vitamin D supplementation?

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19

Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank

Controversies in Vitamin D: Summary Statement From an International Conference

A c c e p t e d M a n u s c r i p t