key: cord-0902414-mawqezup authors: Wang, Lirong; Xu, Tailin title: Editorial: Integrated Point-of-Care Testing (POCT) Systems: Recent Progress and Applications date: 2022-03-01 journal: Front Bioeng Biotechnol DOI: 10.3389/fbioe.2022.851675 sha: ee43c6adf257feb2a4d4f04194c2561ff0977dbe doc_id: 902414 cord_uid: mawqezup nan can not only effectively inhibit bacterial adhesion (the antibacterial efficiency remains above 66%), but also capture and detect nickel ions through chelation reaction (the capture efficiency is about 57% at 5 days), which can be used in implantable biomedical materials and equipment in the future. More importantly, the combination of POCT with nanodiagnostics technology has become the latest trend in the development of fully integrated POCT systems in the field of personal healthcare. A novel approach for the visual detection of the Hepatitis B virus in the clinical application was first developed by Chen et al. by integrating loop-mediated isothermal amplification with a gold nanoparticle-based lateral flow biosensor, and the entire detection process includes genomic DNA extraction (~10 min), preamplification (~40 min), and LFB readout (~2 min) can be completed in 60 min. Similarly, Wang et al. (2021) developed a novel detection method called "CRISPR-HBV" for Hepatitis B virus diagnosis, which can detect 10 copies of genomic DNA with 100% specificity. He et al. provide a promising point-of-care biosensor for a biomarker of Alzheimer's disease (Amyloid-β protein) in which ZnO@ polydopamine/Au nanocomposites has excellent visible-light activity, possessing a wide Linear range (1 pg/ml to 100 ng/ml) and low detection limit (0.26 pg/ml). An intelligent multi-modal point-of-care system combining clinical indicators with CT images was developed to predict transarterial chemoembolization response in hepatocellular carcinoma with 98% accuracy (Sun et al.) . A point-of-care testing system based on a magnetically propelled microdimer was reported for the quantification analysis of plasma glucose, cholesterol, and triglyceride concentrations (Yu et al.) . Hwang et al. presented a magnetic force-assisted electrochemical sandwich immunoassay for the quantitative analysis of carcinoembryonic antigen, which showed a linear relationship of 0.5-200 ng/ml and a detection limit of 0.50 ng/ml. Sun et al. developed a method for the timely diagnosis of B. pertussis infections that combines loop-mediated isothermal amplification and a nanoparticle-based lateral flow biosensor with a sensitivity of 50 fg per reaction. Notably, these works require further follow-up and provide more clinical data to confirm their practicability and accuracy. In conclusion, we have included recent advances and applications of integrated point-of-care testing (POCT) systems in this topic. We hope to bring readers a timely and interesting overview to inspire future attention to multidisciplinary research in materials science, chemistry and biotechnology to address the remaining challenges of integrated POCT systems for personal healthcare. For example, a powerful wearable sensing system integrating new materials, sensing technology and a seamless system is lacking, which can accurately and continuously collect and output data from the human body. Miniaturization and integration of signal processing systems need to be explored to fully exploit the potential of flexible electronics. Considering the complexity of the human body, future research work should also focus on human comfort studies, especially friendly sampling methods and flexible systems that mechanically match the skin interface. Further research in these directions could accelerate the commercialization of such integrated POCT systems, which will have a significant impact on personalized healthcare. LW wrote the draft. TX revised and approved the final version for publication. Wearable Devices for the Detection of COVID-19 Fully Integrated Wearable Sensor Arrays for Multiplexed In Situ Perspiration Analysis Wearable Biosensors for Healthcare Monitoring The Role of Sampling in Wearable Sweat Sensors Paper-Based Ratiometric Fluorescence Analytical Devices towards Point-of-Care Testing of Human Serum Albumin Advances in Sweat Wearables: Sample Extraction, Real-Time Biosensing, and Flexible Platforms Bio-Integrated Wearable Systems: A Comprehensive Review An Epidermal Patch for the Simultaneous Monitoring of Haemodynamic and Metabolic Biomarkers Frontiers in Bioengineering and Biotechnology | www.frontiersin.org Recent Progress, Challenges, and Prospects of Fully Integrated mobile and Wearable point-of-care Testing Systems for Self-Testing Flexible, Self-Healable, Adhesive and Wearable Hydrogel Patch for Colorimetric Sweat Detection Wearable and Flexible Electronics for Continuous Molecular Monitoring The topic editors would like to acknowledge all the authors, reviewers, and scientists who participated in this research topic. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.