key: cord-0901834-7s2yxo1r
authors: Shoskes, Aaron; Migdady, Ibrahim; Fernandez, Anthony; Ruggieri, Paul; Rae-Grant, Alexander
title: Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microangiopathy
date: 2020-07-10
journal: J Stroke Cerebrovasc Dis
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105111
sha: 7356304d8487af993d72b55cba2c235762bf9804
doc_id: 901834
cord_uid: 7s2yxo1r

INTRODUCTION: Since the emergence of Coronavirus Disease 19 (COVID-19) pandemic, multiple neurologic complications in infected patients have been reported. Despite these reports, the mechanism of COVID-19 nervous system injury is not well understood. We report the case of a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin antibodies, and purpuric rash with biopsy showing a thrombotic vasculopathy, all features suggestive of secondary microangiopathy. CASE REPORT: A 69-year-old male with history of hypertension, chronic kidney disease, and hypothyroidism presented with one week of dyspnea, cough, diarrhea, and fevers. Chest x-ray demonstrated bibasilar consolidations and nasopharyngeal reverse transcriptase polymerase chain reaction confirmed SARS-CoV-2 infection. He had subsequent respiratory decline requiring intubation the day after admission. He developed a truncal morbilliform rash and diffuse purpura, a biopsy of which showed small dermal blood vessels with intraluminal microthrombi consistent with thrombotic vasculopathy. He was found to have elevated aCL IgM and IgG and equivocal lupus anticoagulant study. Brain MRI obtained for persistent encephalopathy showed innumerable areas of susceptibility weighted imaging changes throughout the bilateral juxtacortical white matter, corpus callosum, basal ganglia, and brainstem, as well as multiple small areas of FLAIR hyperintensities, consistent with microhemorrhage DISCUSSION: While there have been several reported cases of neurologic manifestations of COVID-19, the pathophysiology may not be related to neurotropism of the virus itself. The new development of antiphospholipid antibodies and thrombotic vasculopathy in dermal blood vessels in this patient suggest a secondary microangiopathy potentially related to a virally-induced inflammatory state.

Since the emergence of Coronavirus Disease 19 (COVID-19), there have been reports of neurological complications in infected patients (1À3). The mechanism of COVID-19 nervous system injury is not fully understood; however, brain magnetic resonance imaging (MRI) findings including diffuse microhemorrhages suggest hypoxia or small vessel vasculitis (4). We report a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin (aCL) antibodies, and purpuric rash with biopsy showing a thrombotic vasculopathy, all features suggestive of secondary microangiopathy.

A 69-year-old male with history of hypertension, chronic kidney disease, and hypothyroidism presented with one week of dyspnea, cough, diarrhea, and fevers. His neurological examination was normal. Laboratory testing showed elevated procalcitonin (0.24 ng/mL, reference < 0.09), Creactive protein (5.1 mg/dL, reference < 0.9), and hypoxemia. Chest x-ray demonstrated bibasilar consolidations and nasopharyngeal reverse transcriptase polymerase chain reaction confirmed SARS-CoV-2 infection. He had subsequent respiratory decline requiring intubation the day after admission. He was found to have elevated ferritin (1551 ng/mL, reference < 565.7), interleukin-6 (77.3 pg/ mL, reference < 6.0), D-Dimer (11,360 ng/mL, reference < 500), and fibrinogen (821 mg/dL, reference < 400). Platelets remained normal throughout hospitalization. He developed a truncal morbilliform rash and diffuse purpura, a biopsy of which showed small dermal blood vessels with intraluminal microthrombi consistent with thrombotic vasculopathy (Fig. 1-A) . He required continuous renal replacement therapy for worsening kidney injury which was complicated by frequent dialysis line clotting. He was found to have elevated aCL IgM and IgG and equivocal lupus anticoagulant study. Despite respiratory improvement, his mental status deteriorated. Brain MRI obtained for persistent encephalopathy showed innumerable areas of susceptibility weighted imaging changes throughout the bilateral juxtacortical white matter, corpus callosum, basal ganglia, and brainstem (Fig. 1ÀB ) as well as multiple small areas of FLAIR (Fig. 1ÀC) and DWI ( Fig. 1ÀD ) hyperintensities, consistent with microhemorrhage. Ultimately, his respiratory and neurologic status declined over the following days resulting in death.

While there have been several reported cases of neurologic manifestations of COVID-19, the pathophysiology remains unclear and may not be related to neurotropism of the virus itself. COVID-19 has been linked to new development of antiphospholipid antibodies (5) , which are known to result in microangiopathy and capillaroscopic microhemorrhages and linked to thrombotic events in patients with rheumatologic diseases (6, 7) . The finding of thrombotic vasculopathy in dermal blood vessels in this patient may provide insight into the pathophysiology of COVID-19-associated cerebral microhemorrhages and suggests a secondary microangiopathy potentially related to the formation of aCL antibodies and inflammatory state.

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