key: cord-0900372-nyvzhglm authors: Dutheil, Frédéric; Bourdel, Nicolas; Comptour, Aurélie title: The Coronavirus Might be Paradoxically Beneficial on the Risk of Autism date: 2020-08-03 journal: J Autism Dev Disord DOI: 10.1007/s10803-020-04621-1 sha: 72042c7d21fce111b48c6fe44060e8a3fa6276b4 doc_id: 900372 cord_uid: nyvzhglm nan Air pollution is a main public health (The Lancet 2017) and economic (Dockery and Evans 2017) issue. Air pollution increases the risk of mortality (Dockery and Evans 2017) and morbidity from a wide range of diseases (especially respiratory, cardiovascular and cardiorespiratory diseases) (Shah et al. 2013; Brugha and Grigg 2014; Loxham et al. 2019) . Moreover, it is now well established that maternal exposure to air pollution increases the risk of developing an autism spectrum disorder (ASD) in newborns (Kerin et al. 2018; Chun et al. 2020; Dutheil et al. 2020) , with a dose-response relationship (McGuinn et al. 2020) . ASD is a challenging pathology with actual global increase of the prevalence (Masi et al. 2017; Kogan et al. 2018) , putatively linked with the increase in air pollution. Considering that there are more than 200 million of pregnancy per year ("WHO Chapter 3" n.d.), there is a huge challenge to limit air pollution during pregnancy. The global Coronavirus Covid19 outbreak reduced dramatically the air pollution such as NO 2 or fine particulates especially in China (Chen et al. 2020) (Fig. 1) . Because of quarantine measures to stop the spread of the virus, people are confined at home, factories activity is slowed down or even stopped in regions the most affected by the virus, transports and commerce have slowed down. This economic slowdown leads to a concomitant consequent decrease of air pollution, first near Wuhan, Hubei Province in China, the initial infection site, then in the whole China (Le et al. 2020) , then worldwide (Berman et al. 2020; Nakada et al. 2020; Stivastava et al. 2020; Zambrano-Monserrate et al. 2020 ). This coronavirus had been responsible for a massive decrease up to 90% of NO2 during the city-lockdown period in Wuhan, 40-60% for China (Le et al. 2020 ) and worldwide megalopolis (Berman et al. 2020; Nakada et al. 2020; Stivastava et al. 2020; Zambrano-Monserrate et al. 2020) . Of course, this observation has to be moderate because this dramatically air pollution reduction will not be permanent: when the Chinese economic activity will resume, industries will catch up rapidly, if the demand is there (Srivastava et al. 2020; Sharma and Balyan 2020) . However, paradoxically, the worldwide outbreak of Covid19 might have some benefits for future newborns, with a decreasing risk of autism because of the reduction of air pollution, and may also have other health benefits on future newborns and mothers, such as avoiding a low-weight at birth, preterm birth (Ritz et al. 2000; Guo et al. 2019; Liu et al. 2019) , stillbirth (Dastoorpoor et al. 2018) , preeclampsia (Pedersen et al. 2014; Nobles et al. 2019) , or gestational diabete (Elshahidi 2019 ). The first draft of the manuscript was written by FD and AC. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. Changes in US air pollution during the COVID-19 pandemic Urban air pollution and respiratory infections Air pollution reduction and mortality benefit during the COVID-19 outbreak in China Maternal exposure to air pollution and risk of autism in children: A systematic review and meta-analysis Acute effects of air pollution on spontaneous abortion, premature delivery, and stillbirth in Ahvaz, Iran: A time-series study. Environmental Science and Pollution Research International Tallying the bills of mortality from air pollution Letter to the editor: Comment on maternal exposure to air pollution and risk of autism in children: A systematic review and meta-analysis Outdoor air pollution and gestational diabetes mellitus: A systematic review and meta-analysis Ambient air pollution and adverse birth outcomes: A systematic review and meta-analysis Association between air pollution exposure, cognitive and adaptive function, and asd severity among children with autism spectrum disorder The prevalence of parentreported autism spectrum disorder among US children Unexpected air pollution with marked emission reductions during the COVID-19 outbreak in China The association between air pollution and preterm birth and low birth weight in Guangdong China The health effects of fine particulate air pollution An overview of autism spectrum disorder, heterogeneity and treatment options Early life exposure to air pollution and autism spectrum disorder: Findings from a multisite case-control study COVID-19 pandemic: Impacts on the air quality during the partial lockdown in São Paulo State Brazil Differential effect of ambient air pollution exposure on risk of gestational hypertension and preeclampsia Ambient air pollution and pregnancy-induced hypertensive disorders: a systematic review and meta-analysis Effect of air pollution on preterm birth among children born in Southern California between Global association of air pollution and heart failure: A systematic review and meta-analysis Air pollution and COVID-19: Is the connect worth its weight? 21-day lockdown in India dramatically reduced air pollution indices in Lucknow UK air pollution and public health WHO. World Health Organization Indirect effects of COVID-19 on the environment