key: cord-0899001-yrsqb0gh authors: Aytekin, Elif Soyak; Soyer, Özge; Şekerel, Bülent E.; Şahiner, Ümit M. title: Subcutaneous Allergen Immunotherapy in Children: Real Life Compliance and Effect of COVID-19 Pandemic on Compliance date: 2021-04-22 journal: Int Arch Allergy Immunol DOI: 10.1159/000514587 sha: 7e1308239992bfba529a024ba4aa4669c3d5cb92 doc_id: 899001 cord_uid: yrsqb0gh BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) is an effective treatment for allergic rhinitis, asthma, and venom allergy. Compliance is essential for SCIT to obtain maximal benefit as it is a long-term treatment. OBJECTIVES: This study aimed to determine the level of real-life SCIT compliance in pediatric patients and the associated factors. Additional aims were to determine how SCIT compliance was affected by the COVID-19 pandemic and why some patients dropped out SCIT. METHOD: Pediatric patients diagnosed with allergic rhinitis, allergic asthma, or venom allergy that received SCIT between September 2012 and July 2020 were analyzed. RESULTS: The study included 201 children (66.7% male) with a median (interquartile range) age of 12.8 years (9.4–15.2) at the time of the first SCIT injection. The overall compliance rate before COVID-19 pandemic was 86.1%. Short SCIT follow-up time and venom anaphylaxis were found to be risk factors for drop out. The leading causes of drop outs were moving to another city/country (32.1%), symptom improvement (17.8%), treatment ineffectiveness (14.2%), and adverse reactions (14.2%). Among the 108 patients that were still receiving SCIT during the COVID-19 pandemic, 31 (28.7%) dropped out the therapy. The most frequent reasons for drop-out were fear of being infected with COVID-19 (35.4%) and thinking that the AIT practise stopped due to COVID-19 pandemic (29%). Male gender and older age were found to be the independent risk factors for drop-out of SCIT. CONCLUSIONS: Real life compliance in children was found 13.9% and it was higher than adults. Nearly one-third of children dropped out during the CO­VID-19 pandemic. Male gender and older age are associated with SCIT drop-out during the COVID-19 pandemic. Allergen immunotherapy (AIT) is an effective and game-changing treatment method for allergic rhinitis (AR), venom anaphylaxis, and allergic asthma that can provide immune tolerance for many years. Subcutaneous allergen immunotherapy (SCIT) is the most commonly used administration route, and requires repeated administration of allergen extracts for 3-5 years, depending on the type of allergen administered. DOI: 10.1159/000514587 Treatment compliance is essential for SCIT to obtain maximal benefit, as it is a long term treatment; however, the non-compliance rate can be as high as 50% in both adults and children [1] [2] [3] . The major factors associated with non-compliance are long duration of treatment, frequency of injections, high cost, improvement of systemic reactions over time, poorly perceived efficacy, allergic reactions during vaccinations, and travelling, and these factors vary according to heathcare center, health system structure, and cultures [4] [5] [6] . Most studies on SCIT compliance are adult-based or population-based (both adults and children); relevant pediatric studies are limited in number [3] . The Coronavirus disease 2019 (COVID- 19) pandemic not only affected people with COVID-19 infection, but also disrupted the treatment of patients with chronic diseases. During the COVID-19 pandemic the pattern of hospital admissions and presentations changed noticeably, and included a decrease in pediatric outpatient presentations for SCIT. The present study aimed to determine the level of real life compliance in pediatric patients and to determine the associated factors. Additional aims were to determine how SCIT compliance was affected by the COVID-19 pandemic and why some patients dropped out the treatment. The study included 201 pediatric patients with AR, allergic asthma or venom anaphylaxis and that underwent SCIT at Hacettepe University Medical School Hospital, Department of Pediatric Allergy, between September 2012 and July 2020. SCIT was administered to patients with AR and/or allergic asthma that had uncontrolled AR symptoms, along with medical treatment and the prescription of avoidance measures. SCIT was given to patiens with asthma only if their disease was allergic and mild to moderate in severity. Venom immunotherapy (VIT) was administered to patients with a history of ≥1 systemic reactions after Apis mellifera and/or Vespula vulgaris stings, and positive diagnostic test reactions (skin prick test [SPT] or specific immunoglobulin E [sIgE]) for culprit insect venom. The treatment compliance of patients in COVID-19 period was defined as the time between the first confirmed case of COVID-19 in Turkey (March 15, 2020) and June 15, 2020. The study protocol was reviewed and approved by our University Institutional Review Board. The diagnoses and therapies of AR, asthma, and venom allergy were based on AR and its impact on asthma (ARIA) [7] , Global Initiative for Asthma (GINA) [8] and European Academy of Allergy and Clinical Immunology guidelines [9] , respectively. Patients were each administered one of the following: Alutard SQ 100% V. vulgaris or A. mellifera (Alutard SQ, ALK, Hørsholm, Denmark) VIT, Allergovit Grass 006 (Allergopharma Joachim Ganzer KG, Hamburg, Germany) allergen immunotherapy; No-voHelisen Depot HDM 50% DP + 50% DF (Allergopharma Joachim Ganzer KG, Hamburg, Germany) allergen immunotherapies. VIT doses were administered at 1-week intervals and were gradually increased to the maintenance dose over the course of 6 months [10] . Then, maintenance doses were administered every 4-6 weeks for ≤5 years [11] . AIT doses for grass allergy and house dust mite (HDM) allergy were administered at 1-week intervals, and were then gradually increased to the maintenance doses over the course of 6 weeks for grass and 14 weeks in HDM [12] . Then, maintenance doses were administered every 4-6 weeks for ≤4 years. Treatment compliance was defined as receiving SCIT according to the prescribed treatment course and evaluated during the 1st year, 2nd year, 3rd year, 4th year, and 5th year, or at treatment completion. Patients with ≤2 two-week breaks from their prescribed treatment schedule per year were considered to have excellent compliance, 3-4 two-week breaks was considered good compliance, 5-6 two-week breaks were considered fair compliance, and ≥7 two-week breaks were considered poor compliance [13] . Patients who had 3 consecutive months delay from their defined treatment schedule were accepted as dropped out [14] , and the reasons for drop-out were recorded. Statistical analyses were performed using SPSS version 22.0 statistical software package (IBM SPSS Statistics, Philadelphia, PA, USA). First normality tests for continuous variables were performed and as all of the continuous variables were distributed nonnormally the results were given as median (inter-quartile range [IQR]). The χ 2 and Mann-Whitney U tests were used to compare nonparametric values. Logistic regression analysis for risk assessment and Kaplan-Meier analysis for change in compliance by time were used. The level of statistical significance was set at p < 0.05. In all, 201 children who received SCIT injections between 2012 September and 2020 March. According to the demographic data, males were predominant (134, 66.7%). Median age at the start of SCIT was 12.8 years (9.4-15.2) and median treatment duration was 40.7 months (20.4-49.9). Patient demographic characteristics are summarized in Table 1 . In total, 154 (76.6%), 10 (5%) and 37 (18.4%) patients were treated with SCIT for AR, asthma and venom anaphylaxis, respectively. Pollen immunotherapy was the most common form of SCIT (78.1%), followed by VIT (18.4%) and HDM (3.5%). Among the patients, 93 (46.2%) Int Arch Allergy Immunol 2021;182:631-636 DOI: 10.1159/000514587 completed the treatment and 108 patients continued to receive SCIT during the course of the study. The overall SCIT compliance rate was 86.1% (173 out of 201 patients). In all, 28 patients (13.9%) stopped AIT before recommended time; 2 patients dropped out during year 1 (0.99%), 10 during year 2 (5.8%), and 16 (10.8%) after 2 years of treatment. Among the compliant group (n = 173), all had excellent compliance during the 1st and 2nd years of therapy. After 2 years of therapy, 93.9% of patients had excellent compliance, 4.6 and 1.5% had good and fair compliance, respectively. The change in compliance over time in the whole group; in females versus males; and in asthma, allergic rhinitis and venom anaphylaxis patients were shown in Figure 1a -c respectively. The duration of treatment in the drop-out group was shorter (p < 0.001) and venom anaphylaxis and asthma were significiantly higher compared to compliant group (p < 0.001) ( Table 1 ). Moving to another city/country (32.1%) was the most frequent reason for drop-out (Table 2). The COVID-19 pandemic started officially in mid-March 2020 in our country. At that time, 108 patients SCIT compliance rate ranges from 44 to 89%. In the present study the compliance rate was higher than reported earlier [3] . Similar to the present findings, Pajno et al. [4] observed SCIT compliance in children of 89%. Among a population of 311 allergic adult and pediatric patients receiving HDM SCIT in China, 34.5% were noncompliant. Ineffectiveness was the leading reason for drop-out (28%) [14] . The cost of SCIT in our country is covered by the national social security system, which might have been a major reason for high compliance rate observed in the present study. The present findings show that SCIT drop-out was significiantly higher in the patients treated for asthma and venom anaphylaxis. As the patients that received VIT lived in a different city, most of them dropped out due to the long-distance commute and/or frequency of injections. One study reported that allergic conjunctivitis was associated with SCIT non-compliance, whereas another study reported that patients with asthma and AR were more compliant [15, 16] . More and Hagan [17] reported that the type of respiratory allergic disease was not correlated with SCIT compliance. Studies that compared SCIT compliance according to age have reported inconsistent findings [18, 19] . Yang et al. [14] noted that children had a higher compliance rate than adults, whereas Lee et al. [20] observed that patients aged <20 years and 20-40 years were more likely to be non-compliant than those aged >40 years. Rhodes [21] reported that non-compliant patients were younger than compliant patients. In the present study, gender did not affect the SCIT compliance rate before the COVID-19 pandemic; however, during the pandemic period males dropped out more than females, significantly. Musa et al. [5] and Gelincik et al. [19] found no correlation with gender, whereas Yang et al. [14] and Lower et al. [2] reported that SCIT compliance was higher among males. The present findings show that moving to another city was the most common reason (32.9%) for SCIT drop-out, followed by symptom improvement (17.9%). Lourenco reported that 23% of patients dropped out during SCIT because of clinical improvement, primarily during the 2nd and 3rd years of treatment [18] . Yang et al. [14] reported it as 22%. We found treatment ineffectiveness (14.3%) as another important reason of AIT drop-outs. Ineffectiveness was reported in previous studies in 8-66% of drop-out results [1, 4, 14, 18, 19] . Adverse reactions were also reported in several studies as a reason for drop-outs in 3.9 to −11% of drop-outs [18, 21] . Systemic reactions were also one of the leading reasons for drop-out (14.3%) in the present study although it was not reported frequently in our center previously [22, 23] . In contrast to literature, the cost of SCIT was not a reason for drop-out in the present study, most likely because it is paid for social security system of our country. In the present study, fear of being infected with CO-VID-19 was the most common reason for SCIT drop-out during the COVID-19 pandemic. Although all necessary precautions were taken, the patients chose not to continue to SCIT, as the hospital was a COVID-19 pandemic center. In all, 29% of the patients dropped because they thought SCID was cancelled based on news reports that the hospital was admitting only emergencies. In addition, during the COVID-19 pandemic period, all intercity travel was banned and, in most of the cities curfews were put into effect. As a result of this situation 22.7% of patients dropped out due to transportation problems. In addition, 6.5% of the patients could not access to allergen extract and 1 patient was unable to continue SCIT, as his father (a health worker) was hospitalized with COVID-19 pneumonia. One patient's AIT was terminated earlier, who was an out of town patient and in the final months of AIT. In the present study, older age and male gender were correlated with drop-out during the COVID-19 pandem-ic. Closure of schools and home-quarantine during pandemic was reported to cause anxiety in adolescents [24] . In conclusion the present study showed that the SCIT compliance in pediatric patients is 86.1% and higher than adults. Moving to another city, improvement of symptoms and treatment ineffectiveness are the leading reasons for drop-out. In addition, the COVID-19 pandemic significiantly reduced the SCIT compliance rate, nearly one-third of children, especially in older ages and males. Determinants of patient compliance with allergen immunotherapy Compliance with allergen immunotherapy Patient's compliance with allergen immunotherapy Children's compliance with allergen immunotherapy according to administration routes Compliance with allergen immunotherapy and factors affecting compliance among patients with respiratory allergies. 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Asia Pac Psychiatry We thank to the pediatric allergy department staff that prepared, coordinated and administered the SCIT program. The study was conducted ethically in accordance with the World Medical Association Declaration of Helsinki, and the use of data for this study was approved by the local Ethics Committee of Hacettepe University, Ankara Turkey (IRB No. 2020/14-15) Due to the retrospective nature of the study anonymity of the data ethical comittee did not request informed consent from the study participants and families.The authors did not receive any funding. E.S.A. collected the data and wrote the article, O.S. made the statistical analysis, B.E.S. contiributed in the study design and the discussoin, U.M.S. planned the study and supervised the whole manuscript. The authors have no conflicts of interest to declare.