key: cord-0898571-fy76995n
authors: Prasad, Arti; Kothari, Naresh
title: Cow products: boon to human health and food security
date: 2021-12-11
journal: Trop Anim Health Prod
DOI: 10.1007/s11250-021-03014-5
sha: 44f81caabc9d67695f10ffbbcda4c8e0597cdd14
doc_id: 898571
cord_uid: fy76995n

The world population exceeded 7.8 billion people in 2020 and is predicted to reach 9.9 billion by 2050 as per the current increasing rate of 25%. In view of this, ensuring human health and food security has become an issue of key importance to countries with different degrees of economic development. At the same time, the livestock sector plays a strategic role in improving the economic, environmental, and sociocultural stewardship of any nation. The cow (Bos indicus) has held a distinctive role in human history ever since its domestication because of its valued harvests like dairy products (milk, clarified butter, yogurt, curd, and buttermilk) excreta like dung and urine. These products, except dung, provide all the necessary energy and nutrients to ensure the proper growth and development of the human. They are the source of many bioactive substances, which possess immense pharmacotherapeutic action against various physiological, metabolic and infectious disorders, including COVID-19. The use of urine and dung can be considered a low-cost agricultural practice for farmers and has been extensively used in modern agriculture practices to ensure food security via soil fertility, plant pathogens, and pests. Cow urine mediated synthesized nanomaterial also display distinctive characteristics and novel applications in various fields of science and technology. Thus, this paper aims to provide a comprehensive overview of cow products, describing their biochemical constituents, bioactivities, and their utilization in the area ranging from human welfare to agriculture sustainability. An attempt is also made to present possible applications in bioenergy production and pollution reduction.

Health and food security are essential to all organisms, most pointedly to human beings. Primarily both are states of cognizance as well as physical conditions, and if they are inattentive, the human being can die eventually (Friel and Ford 2015) . Food security is also a part of the panoply of conditions that signal directly compromised human beings' health status (Gregory and Coleman-Jensen 2017) . It has worsened the effects of all types of diseases (i.e., infectious diseases, deficiency diseases, physiological diseases, etc.) and can accelerate negative perceptions of self-worth in children and elders (Siddique et al. 2017; Wells et al. 2020) . In view of the current population growth, which is exceeded 7.8 billion in 2020 and is predicted to reach 9.9 billion by 2050, human health and food security are probably the major global issue (Pawlak and Kołodziejczak 2020) . The United Nations (UN) has introduced health and food security as a prime concern among Sustainable Development Goals (SDG) and set different targets to resolve this issue with available resources (Pérez-Escamilla 2017; Gil et al. 2019) . Cattle, including cows (female) and bulls (male), have held a very distinctive role in human history ever since their domestication. Earlier, they were raised for their products like milk, meat, and leather and are also used as draft animals in farming and transport practices (McInerney 2010) . Nowadays, they are important contributors to any developing nation's economic, environmental, and sociocultural stewardship across Europe, Asia, and sub-Saharan Africa. In Asia and sub-Saharan Africa, 75% of the rural population and 25% of the urban population are directly benefited by the cattle in terms of food, income, employment, and social security (Enahoro et al. 2019; Varijakshapanicker et al. 2019) . The cow (Bos taurus or Bos indicus) has been placed at a high pedestal for enormous usages of their valued harvests like the dairy products (colostrum, milk, clarified

The secretion or products of animal origin, especially bovine animals, have been mentioned as healthcare remedies in most ancient medicine systems, including Traditional Chinese Medicine, Western Medicine, and Indian Medicine. Due to their broad spectrum of nutritional components and bioactivities has also received attention from modern pharmacopeia and many other research fields. The following are only a few examples (discussed in sub-sections) to illustrate the utilization of cow products in the area ranging from human nutrition to pharmacotherapeutics.

Since ancient times, rural and urban households have used different cow products in their everyday lives without bothering much about their nutritional and other scientific context. Nutritional studies in the last few decades showed cow products, especially milk and milk-derived products, to be complete, versatile, and nutritious foods for humans . It seems that such products are nutrientdense and provide high-quality dietary supplements (i.e., carbohydrates, protein, fat, micronutrients, etc.) in an easily absorbed form that can advantage both nutritionally vulnerable and healthy peoples (Buttar et al. 2017; Panahipour et al. 2018 ). Among cow products, colostrum (first mammary secretion during the first 0-120 h after delivery) and milk are the old trusted form of health drink, which roots back to ancient pharmacopeia and till today regarded as imperious stuff for the holistic growth and development of the body (Puppel et al. 2019; Sharma et al. 2019) . Cows can provide readily available nutrient-rich colostrum and milk in large quantities. Nutritionally, they are a source of dietary supplements and the source of a wide variety of protective factors (Fig. 1) . However, colostrum is considered the most Fig. 1 Overview of different constituents present in cow colostrum and milk. β-LG = β-lactoglobulin, α-LA = α-lactalbumin, BSA = bovine serum albumin, LF = lactoferrin, IL = interleukins, IFN = interferon, TNF = tumor necrosis factor, TGF = transforming growth factor, PRP = proline-rich polypeptide, G-CSF = granulocyte colony-stimulating factor, M-CSF = macrophage colony-stimulating factor, GM-CSF = granulocyte-macrophage colony stimulating factor nutritive form of cow milk, but its biological and nurturing value decreases over time (Table 1) . Earlier, colostrum was usually consumed in its liquid form for the dietary purpose of both children and adults worldwide (Butter et al. 2017) . Nowadays, the solid form is used to manufacture colostrumbased nutraceuticals that are dispensed and formulated into capsules, tablets, and powder using low-heat pasteurization and indirect steam drying (Dzik et al. 2017) . Cow milk has the highest consumption among animal milk in India, Brazil, China, Sudan, Ethiopia, the USA, Argentina, and Paraguay. Antony et al. (2018) reported that it has a 90% share in world total milk production, followed by buffalo milk (5%), goat milk (3%), and sheep milk (2%). Cow milk appeared to occupy a unique position among many dietary foods as it contains a sufficient concentration of valued nutrients that ensure the necessary nutrient needs for humans' cognitive and physical development (Table 2) . Proteins are the fundamental part of cow milk and mainly comprise a soluble component (whey protein, 20% of milk protein fraction) and an insoluble component (caseins protein, 80% of milk protein fraction). Nutritionally, both components are good sources of amino acids, which are essential for the growth and health maintenance of human beings (El-Sayed and Awad 2019; Scholz-Ahrens et al. 2020). Cow milk is considered a high-quality protein source compared to goat milk, taking into account the essential amino acid, especially isoleucine, threonine, methionine, and tyrosine (Table 3) . Clarified butter known as "ghee" prepared by heating milk, is also considered a good source of lipophilic composition such as conjugated linoleic acid and vitamins (A and E) that exhibited several nutraceutical actions, both in vitro and in vivo (Rani and Kansal 2012; Pena-Serna and Restrepo-Betancur 2020) . Cow milk yogurt is also popular nutritious fermented food and is usually consumed for dietary purposes worldwide. Mainly, fat (total lipid) constitutes the main fraction of both clarified butter as well as yogurt and (Mohanvel et al. 2017; Ketan et al. 2020) . Studies also confirmed that cow dung harbors a rich microbial diversity and a good source of essential enzymes and metabolites of human interest (Gupta et al. 2016; Semwal et al. 2019) . Joseph et al. (2020) revealed 20 bioactive compounds in Bos indicus and Bos taurus dung samples. However, cow breeds with differences in genetic makeup and several other aspects (i.e., age of animal, lactation and gestation stage of the animal, feed-related factors, and climatic influences) have a striking effect on chemical composition as well as the nutritional value of different cow products (Singhal et al. 2016; Puppel et al. 2019 ).

Cow products are well known for their traditional practices of medicine since time immemorial. These products have received extensive importance in Ayurveda, while slighter attention has been given to Traditional Chinese Medicine and Western Medicine (Wang and Carey 2014; Rai 2019) . Ayurvedic classics such as Charak Samhita, Sushruta Samhita, Bhaisajya Ratnavali, and Arya-Bhishak described different properties of cow products and therapeutic potentials. Cow milk has been mentioned for its ability to strengthens the seven Dhatus (tissues) such as Rasa (plasma), Rakta (blood), Mamsa (muscle), Meda (adipose tissue), Asthi (bone), Majja (bone marrow), and Shukra (reproductive tissue) in Charak Samhita. It has also been used to improve memory and boost immunity (Raut and Vaidya 2018) . Cow ghee or Ghrita (clarified butter) has been mentioned to treat wounds, chronic fevers and nourish the body tissues and vital fluid. Fresh butter is considered for curing skin diseases and several other problems caused due to blood impurity (Shukla et al. 2012; Joshi 2014) . In Ayurvedic therapeutics, cow urine (Gomutra) is frequently referred to for use because of its yearlong availability, cost-effectiveness, and special sanctity attached to the cow in India. In Charak Samhita, it is mentioned as a regulator governing several abdominal and dermatological disorders such as itching (Kandu), eczema (Vicharchika), and acne vulgaris (Yauvanpidika). Similarly, Sushruta Samhita described their properties as a cognition enhancer (Medhya) and reversal of certain cardiac (Hrid Roga), gastrointestinal (Udar Roga), and kidney-related problems (Randhawa and Sharma 2015; Steer 2019) . The therapeutic potential of Panchgavya has been described in Apasmar-Chikitsa-Adhyaya of Charak Samhita with specific indications for cognitive and memory decline (Apasmar). It is also mentioned for the prevention of jaundice (Kamala), fever (Jwara), arthritis (Amavata), ulcer (Mukhapaka), asthma (Tamakaswasa), and brain disorder (Raut and Vaidya 2018) . Similarly, cow bile has been described to treat a wide number of disorders in Traditional Chinese Medicine (Wang and Carey 2014) . 

In the prevailing trend toward natural bioactive products, there seems to be an increasing preference for different cow products associated with various perceived health benefits (Pereira et al. 2014; Mandavgane and Kulkarni 2020) . The active constituents of the cow milk, especially proteins (i.e., caseins, lactoferrin, and albumins), immunoglobulin (IgG, IgM, IgE, and IgD), and cytokines (interleukins and interferon), have been widely used in the treatment of several physiological or metabolic disordered related to the brain, kidney, heart, and other organs ). These active constituents have a significant protective influence on specific disease conditions of particular target organs by modulating signaling pathways and other elements (Mohanvel et al. 2017; Jawhara et al. 2020) . Peptides derived from the digestion of cow proteins have demonstrated anticancer and antimutagenic properties, including mechanisms of DNA damage mitigation and apoptosis induction via both the extrinsic and intrinsic pathways (Pepe et al. 2013; El-Fakharany et al. 2018; Sharma et al. 2019 ). Milk-derived extracellular vesicles contained several immunomodulatory miRNAs and membrane protein CD63, characteristics of exosomes (Pieters et al., 2015; Benmoussa et al., 2016) . Panahipour et al. (2018) reported that pasteurized cow milk and the aqueous fractions of yogurt and buttermilk enhanced the expression of TGF-β target genes (IL11, NOX4, and PRG4) in gingival fibroblasts. Lactoferrin is a major ironbinding glycoprotein from cow milk known to have an immunomodulatory role, and recently, their immunocompetence efficacy has been emphasized against SARS coronavirus 2 (SARS-CoV-2) or COVID-19 (Mann and Ndung 2020) . The active constituents of cow urine prevent the free radical formation, act as bio-enhancer, reduce blood glucose, and efficiently repair the damaged DNA, thus showing anticancer and anti-diabetic efficacy (Dutta et al. 2006; Mohanvel et al. 2017) . Recently, Padvi et al.

(2020) suggested that cow urine mediated synthesized copper oxide nanoparticles (CuO NPs) can be used for antineoplastic therapy. The cow products also displayed inhibitory effects against various human pathogenic microorganisms (Randhawa and Sharma 2015; Hoh and Dhanashree 2017) . Likewise, cow urine mediated synthesized CuO NPs, palladium nanoparticles (PdNPs), and silver oxide nanoparticles (Ag2ONPs) exhibit excellent antimicrobial activity against various strains of bacteria and fungi (Vinay et al. 2019; Prasad et al. 2020; . Table 4 summarizes the evidenced-based pharmacotherapeutic potential of different cow products and their possible action mechanism.

Studies on cow milk and other dairy products consumption have shown a controversial and complex effect on human health. For instance, lactose is the main carbohydrate present in cow milk which is further hydrolyzed into two isomeric forms, alpha, and beta by a b-galactosidase known as lactase (Schaafsma et al. 2008) . Lactose intolerance or b-galactosidase deficiency is an overlay term, and more than 50% of the world population has persistent lactose intolerance. Lactose intolerance or b-galactosidase deficiency causes several gastrointestinal distresses like abdominal cramps and bloating, flatulence, diarrhea, nausea, and vomiting (Matthews et al. 2005; Pereira 2014 ). Currently, there is also a growing concern about the consequences of cow milk β-caseins (A1 β-casein and A2 β-casein) on lactose intolerance (Brooke-Taylor et al. 2017; Daniloski et al. 2021) . A1 β-casein generally contains a histidine amino residue at 67 positions, which is more likely to undergo enzymatic cleavage yielding in the product β-casomorphin-7 (BCM-7), a recognized μ-opioid receptor agonist. It has also been reported to exert various adverse effects on the gastrointestinal system (i.e., increased inflammation, worsening of post-dairy digestive discomfort symptoms, delayed transit, motility, etc.) in lactose tolerant and lactose intolerant subjects (Jianqin et al. 2015; Summer et al. 2020) . While A2 β-casein contains a proline residue at this site and is unlikely to undergo enzymatic cleavage. It did not aggravate such gastrointestinal dysfunctions in subjects with lactose intolerance (He et al., 2017) . Recent clinical studies have demonstrated that gastrointestinal symptoms of milk intolerance can be avoided by consuming milk containing only the A2 β-casein (Sheng et al. 2019; Ramakrishnan et al. 2020; Kay et al. 2021) . Likewise, cow milk protein allergy can be associated with IgE reactions, and immediate reaction symptoms include anaphylaxis, edema, and much gastrointestinal distress such as vomiting, diarrhea, and bloody stools (Fiocchi et al. 2010) . Some studies reinforce the role of cow milk and other milk-derived products as important nutrient sources, justifying their place in a healthy diet (Pereira 2014; Butter et al. 2017) , whereas others suggest a possible association of milk consumption with increased risk for obesity, diabetes, osteoporosis, cancer, and cardiovascular disease (Holmberg et al. 2009; Tunick and Van Hekken 2015) . Thorning et al. (2016) has performed a detailed meta-analysis study on milk, and dairy products suggested that intake of milk and dairy products contribute to meet nutrient recommendations and may protect against the most prevalent chronic diseases with the least adverse reports (Fig. 2 ). In addition, the presence of pesticide residues as well as heavy metals in milk and dairy products is well evidenced throughout the world, which can be responsible for many harmful effects on human health (Norouzirad et al. 2018; Jadhav et al. 2019) .

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Since human civilization, agricultural practices have played a strategic role in improving the availability of food and achieving food security. In the current scenario, global agricultural production is mainly associated with two major problems: first, environmental measures as floods, droughts, and variability in temperature or rainfall, secondly plant disease because plant pathogens are difficult to control as their population shows variability with time, space and genotype. The indiscriminate use of agrochemicals adversely affected soil fertility, crop productivity, and, more specifically, the environmental system is also a major bottleneck. In order to combat the losses caused by such factors, it is necessary to define the problem and seek eco-friendly remedies. Cow products, especially urine and dung, can be considered a low-cost agricultural practice for farmers and has been extensively used in traditional and modern agriculture practices like organic farming and hydroponics. Therefore, in sub-sections, we summarized the utilization of different cow products in areas ranging from plant disease control to yield attributes and soil sustainably.

The agricultural harvests of food interest, mainly crops, vegetables, and fruits, are often seen to be infected by one or the group of pathogens and pests, causing a loss in yield and sometimes even the quality (Savary et al. 2012 ). One reason is that pathogens and pests have co-evolved with vegetation since the origin of the human-made agricultural system (Pathak et al. 2018) . At a global scale, pathogens and pests are causing an average 30% yield losses in six most important food crop, including wheat (10-28%), rice (25-41%), maize (20-41%), potato (8-21%), and soybean (11-32%) losses (Savary et al. 2019) . For millennia, cow urine and dung have been extensively used in traditional agriculture practices. There has been a spate of literature on these products, particularly concerning their use in the management of different diseases and harmful pests. It seems that the treatment combination of cow urine and cow dung shows marked effect on certain disease-causing phytopathogen through either a direct or indirect mechanism (Table 5) . Apart from this, several green bio-formulations have been prepared by mixing ratio of either the dung or urine with distinct botanicals, which can be used as pest repellent in agricultural practices (Mandavgane et al. 2005; Kumawat et al. 2014 ). Agniastra is a natural bio-pesticide prepared by mixing up cow urine with neem leaf extract (Azadirachta indica) and ginger paste. Similarly, Neemastra is a board spectrum bio-pesticide commonly prepared by mixing up cow dung and cow urine with neem leaf extract and water. Its uses on crops provide the resistance to several pests and increase the overall crop productivity due to the immunostimulant stirring of the active principles in both the cow urine and neem leaf extract (Chaudhary et al. 2017; Rawat et al. 2020 ). Brhmastra and Dashaparniarka have also been prepared by mixing cow waste with multiple botanicals (i.e., Annona reticulata, Carica papaya, Punica granatum, Psidium guajava, etc.), and water. Its foliar applications have been reported to exert protection and strong repellence against sucking pests, pod/fruit borers, and some mosquitos (Soni and Yadav 2019; Middya et al. 2020) . The research focuses on cow urine and cow dung microbiota, which possesses antagonistic effects against disease-causing pathogens and pests. Bacillus subtilis strains are the most predominant isolates from cow dung that have displayed adverse effects against phytopathogenic fungi Rhizoctonia bataticola, Fusarium soalni, and Fusarium oxysporum (Swain et al. 2012; Radha et al. 2014) . Likewise, Lu et al. (2014) has investigated bacterial strains (belongs to genera Bacillus, Proteus, Providencia, Pseudomonas, Staphylococcus, and Microbacterium) from cow dung for nematicidal activity against two predominant nematode Caenorhabditis elegans and Meloidogyne incognita. The author revealed that most of the isolated strains displayed antagonistic activity against both the nematodes. Piasai and Sudsanguan (2018) have investigated four species of Gelasinospora isolated from cow dung against plant pathogenic fungi. It has been observed that all isolates of Gelasinospora inhibited mycelial growth of Phytophthora palmivora, Alternaria alternata, Colletotrichum capsici, and Curvularia lunata.

Overview on effects or association between dairy product intake and health outcomes. + = favorable effect/association, * = no effect/association,-= adverse effect/association 

Highest inhibition of conidial germination (%) was found after 2 h of incubation, while highest mycelial growth inhibition (%) was found after 7 days of incubation of both urine and dung Basak et al. 2002 Streptomyces strains procured from cow dung have also displayed decent antagonistic activity against the strain of genera Aspergillus, Fusarium, Macrophomina, and Rhizoctonia solani (Semwal et al. 2018 ).

Toward a food security vision, crops need to be equipped with better growth, yield, and nutritional properties (Gimenez et al. 2018) . To fulfill the above-desired crop characteristic, one possibility is to use products that themselves have to boost means and can strengthen plant health and yields (Raklami et al. 2019) . Cow products are the rich source of various inorganic and organic substances, which can regulate plants' physiological and biochemical mechanisms (Mandavgane and Kulkarni 2020) . Different cow products and their formulations, such as Panchgavya, Beejamrut, Amritpaani, etc., have been extensively evaluated to sustain agricultural production in terms of growth, yield, and nutritional qualities of the crop plants (Table 6 ). Panchgavya is well-recognized liquid manure for this purpose, while Beejamrut and Amritpaani are considered good sources for plant growth stimulation (Barar et al. 2019). Generally, these formulations have been prepared by thoroughly mixing cow dung, cow urine, and other ingredients. Its uses on crops increase crop plants' overall biological efficiency, quality, and yield (Aswani et al. 2020; Dodamani et al. 2020) . The treatment combination of such liquid organic inputs with other bio-formulations has shown encouraging results in reducing the overall cost of crop cultivation practices (Tripura et al. 2018 ). In the recent past, the focus has also shifted towards cow waste as a potential source for plant growth-promoting bacteria (PGPBs) which have active compounds of multifarious importance for plant growth promotion (Girija et al. 2013; Bhatt and Maheshwari 2019) . Several strains of PGPBs have been isolated from cow dung and explored to augment and boost plant biological, functional, and nutritional assets (Lin et al. 2018; Bhatt and Maheshwari 2020) .

Since the green revolution, indiscriminate and disproportionate uses of agrochemicals like chemical fertilizer and pesticide resulted severe threat to soil sustainability (Elbana et al. 2019) . Both the cow urine and dung contain significant amounts of major nutrients like nitrogen (N), phosphorus (P), and potassium (K) required for soil mineral balance and fertility. Singh et al. (2014) has reported that high dose of cow urine application resulted in increased dissolved nutrients of amended soils. Significantly higher soil organic carbon and available N, P, and K were obtained with the applications of cow urine with other formulations (Kgasudi et al. 2020 ). On the other hand, cow dung has been considered as low-cost natural fertilizer because it supplements good organic matter (Mukhuba et al. 2018) . Jeevamrut is a natural liquid fertilizer prepared by mixing cow dung and cow urine with other ingredients (i.e. jaggery, legume flour, etc.). It contains the huge count of microbial load that enriches the biological and mineral balance of the soil (Pathak and Ram 2013; Boraiah et al. 2017; Jain et al. 2021) . Similarly, cow dung and cow urine-based compost are one of the most significant and frequently used organic matter in integrated soil management practices.

Research shows that compost applications improve the nutritional balance of the soil and the soil texture and structure (Iwuagwu et al. 2019; Nguyen et al. 2020; Shafique et al. 2021) . Ghana Jeevamrutham is the solid or granular form of Jeevamrut and also acts as natural fertilizer. It is a low-cost improvised preparation that enriches the soil with beneficial microfunna. The treatment of Ghana Jeevamrutham in balanced forms has improved soil fertility and maintained various crops' nutritional quality (Sawant et al. 2019; Barar et al. 2019) . Research interest is also given to the indigenous microbial diversity of cow dung as they can transform soil nutrient profiles via processes like solubilization, chelation, mineralization, and oxidation or reduction (Radha et al. 2014; Bhatt and Maheshwari 2019; Aiysha and Latif 2019) . Recently, Adekiya et al. (2020) has reported that cow dung biochar application improves the nutritional profiles (soil pH, organic carbon, N, P, K, Ca, Mg, moisture contents) and the culturable microflora of the soils.

Cow products displayed miscellaneous applications in some other valuable aspects like bioenergy production and pollution reduction, which are described below under subsections. To respect the length of the paper, the detailed outcomes of respected studies are avoided in this paper, while interested readers may refer to cited documents. In addition, summarized result of the case study report on cow productbased manufacturing unit (Mandavgane and Kulkarni 2020) is pictorially presented in Fig. 3 .

Ever-increasing energy demands for day-to-day human activities such as transportation and industrial practices have depleted the non-renewal energy source and caused drastic environmental intrusions (Joshi et al. 2019; Halkos et al. 2020) . Renewable energy in the form of biofuels and biogas offers the opportunity to improve access to modern energy services for the global community (Achinas et al. 2017 ; Sharma et al. 2017b; Joshi et al. 2020) . For long, caked or dried cow dung has traditionally been used by households as cooking fuels in many parts of the developing world. In the last two decades, there has been increasing research interest in bioenergy production, especially biogas using cow dung as substrate (Gupta et al. 2016; Mandavgane and Kulkarni 2020) . On average, 1 kg of cow dung can produce 35-40 l of biogas (Kalia and Singh 2004) , while dung generated from 3 to 5 cattle/day can run an 8-10 m3 biogas plant which can produce 1.5-2 m 3 biogases per day. Research also continues to enhance biogas production via the use of additives, recycling of slurry and slurry filtrate, variation in operational parameters (i.e., temperature, hydraulic retention time, and particle size of the substrate), and use of fixed-film/biofilters Haryanto et al. 2018; Adekunle et al. 2019; Obileke et al. 2020) . Activated carbon has also been synthesized from cow dung by a modified chemical activation method. The synthesized activated carbon reflects excellent properties like a supercapacitor with a distinct electrochemical application (Li et al. 2018; Ramalingam et al. 2020) . Some recent studies also suggest that cow dung can be converted into an electrode material for energy conversion systems such as Li-ion batteries and fuel cells (Feng et al. 2018; Thiruselvi et al. 2020 ).

Bioremediation using microbes is a widely accepted method for the removal of hazardous environmental pollutants (Giovanella et al. 2020) . Hydrocarbon and heavy metals are the major pollutants in water as well soil and pose a serious threat to living creatures and environments (Wang et al. 2020) . Literature suggests that the cow dung contains a diverse group of microorganisms capable of biodegradation of hydrocarbons into environmentally friendly elements (Aghalibe et al. 2017; Varjani et al. 2017; Neethu et al. 2019) . Another practical application of cow dung microorganisms is in the remediation of heavy metals like chromium, strontium, and arsenic (Wang et al., 2017) . Many cow dung strains have been applied to biodegrade biomedical and pharmaceutical waste (Randhawa and Kullar 2011; Patil et al. 2019) . Cow dung ash (CDA) has also been explored as a low-cost adsorbent to remove textile dyes and other organic contaminants (Ahmad et al. 2020 ). Recently, cow urine mediated synthesized silver oxide (Ag2O) nanoparticles show good photocatalytic degradation of methylene blue (Vinay et al. 2019 ).

The present review deals with the first comprehensive outlook on cow products to human health and food security, the prime most concern among United Nations Sustainable Development Goals. The nutritional richness of cow milk and other dairy products is unquestionable; they are a good source of high biological value substances with polyvalent roles in immune function, as well as pharmacological actions. Understanding the mechanisms enabling their biological process can promote novel applications in the nutraceutical and pharmaceutical sectors. Cow excreta like urine and dung contains distinct compounds for human interest and is an effective tool to sustain agriculture production via governing soil sustainability, plant health, and yield attributes. The application of cow urine and dung microflora potential can promote both human health and plant health; however, comprehensive screening of these microorganisms for the production of virtuous antimicrobials, enzymes, and metabolites needed to be investigated. It is undoubtedly evident that more detailed studies of cow products are required, as there is still tremendous scope for advancing research and development to novel applications in various fields of science and technology, including bioenergy and pollution abatement in a green and clean manner.

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Antifungal effect of cow's urine distillate on Candida species

Food choices and coronary heart disease: a population based cohort study of rural Swedish men with 12 years of follow-up

2016. Hodowca Bydła

Soil chemical properties and nutrient composition of cocoyam grown in an organically fertilized soil

A unified approach for high-throughput quantitative analysis of the residues of multi-class veterinary drugs and pesticides in bovine milk using

Microbiological and enzymatic properties of diverse Jaivik Krishi inputs used in organic farming

Efficacy of cow urine as plant growth enhancer and antifungal agent Advances in Agriculture

Antidiabetic activity of cow urine 562 and a herbal preparation prepared using cow urine

Can drinking microfiltered raw immune milk from cows immunized against SARS-CoV-2 provide short-term protection against COVID-19?

Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows' milk

Comparative analysis on bioactive compounds presents in dung material of Bos taurus and Bos indicus. Materials Today: Proceedings

Current scenario of potential renewable energy sources for sustainable development in India

Halophytes: The Nonconventional Crops as Source of Biofuel Production

Docosahexaenoic acid content is significantly higher in ghrita prepared by traditional Ayurvedic method

Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats

Effects of Dung Beetle-Amended Soil on Growth, Physiology, and Metabolite Contents of Bok Choy and Improvement in Soil Conditions

Development of a biogas plant

Beneficial Effects of Milk Having A2 β-Casein Protein: Myth or Reality

Prevention of apparent adiposity by fractions of distilled cow urine: a non-invasive approach

Cow Urine: A Plant Growth Enhancer, Bio Fertilizer, Pesticide and Antifungal Agent

Antistress activity of different compositions of Panchgavya and Aloe barbadensis Mill by using tail suspension method

Effect of cow urine and Bio-Fertilizers based fertigation schedule at varying levels of drip Irrigation on yield, growth, quality parameters and economics of cucumber under protected condition

Effect of panchagavya on germination and seedling growh of balsam (Impatiens balsamina). Plant Archives

Formulation of biopesticides for insect pests and diseases management in organic farming

In vitro study of lipid peroxidation and free radical scavenging activity of cow urine

Production of activated carbon from cow manure for wastewater treatment

Dry anaerobic co-digestion of cow dung with pig manure for methane production

Influence of plant growth-promoting rhizobacteria on corn growth under different fertility sources

Identification and nematicidal activity of bacteria isolated from cow dung

Protective Effect of Cow Urine Distillate in Streptozotocin Induced Type I Diabetes in Rats

Valorization of Cow Urine and Dung: A Model Biorefinery

Development of cow dung based herbal mosquito repellent

The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19

Lipid-lowering activity of cow urine ark in guinea pigs fed with a high cholesterol diet

Systemic lactose intolerance: a new perspective on an old problem

The cattle of the sun: cows and culture in the world of the ancient Greeks

Effect of foliar application of liquid organic and inorganic fertilizers along with NAAon cowpea (Vigna unguiculata)

Field Efficacy of Fungicides and Bio-Botanicals against Late Blight Disease of Potato

Histomorphological evaluation of wound healing potential of cow urine in goats

Cow Urine Distillate As A Bioenhancer For Antimicrobial & Antiproliferative Activity And Redistilled Cow Urine Distillate As An Anticlastogen Agent

Comparative assessment of bio-fertiliser quality of cow dung and anaerobic digestion effluent

Study on cow urine and Linn seed in farmyard: A natural, cost effective, ecofriendly remedy to bacterial leaf blight (BLB) of paddy

Cow dung as a bioremediation agent to petroleum hydrocarbon contaminated agricultural soils

Laboratory evaluation of some botanicals and fermented cow urine against Chilo partellus (Swinhoe) (Lepidoptera: Crambidae)

Comparison of the nitrogen balance in paddy fields under conventional rice straw application versus cow dung compost application in mixed crop-livestock systems

Lead and cadmium levels in raw bovine milk and dietary risk assessment in areas near petroleum extraction industries

Design and Fabrication of a Plastic Biogas Digester for the Production of Biogas from Cow Dung

Bos taurus Urine Assisted Biosynthesis of CuO Nanomaterials: A New Paradigm of Antimicrobial and Antineoplatic Therapy Macromolecular Symposia

TGF-β activity in cow milk and fermented milk products: an in vitro bioassay with oral fibroblasts

Effect of Panchagavya on growth yield and economics of chickpea (Cicer arietinum)

Biological control of phytopathogenic fungus Colletotrichum falcatum using Bos taurus (cow) urine and dung

Impact of climate change on host, pathogen and plant disease adaptation regime: a review

Bio-enhancers: A potential tool to improve soil fertility, plant health in organic production of horticultural crops

Conversion of organic biomedical waste into potential fertilizer using isolated organisms from cow dung for a cleaner environment

The role of agriculture in ensuring food security in developing countries: Considerations in the context of the problem of sustainable food production

Chemical, physicochemical, microbiological and sensory characterization of cow and buffalo ghee

Potential anticarcinogenic peptides from bovine milk

Milk nutritional composition and its role in human health

Food security and the 2015-2030 sustainable development goals: From human to planetary health: Perspectives and opinions. Current Developments in Nutrition

Morphological study of Gelasinospora from dung and antagonistic effect against plant pathogenic fungi in vitro. Agriculture and Natural Resources

Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β

Effect of panchakavya (organic formulation) on phytoremediation of lead and zinc using Zea mays

Effect of fertility levels and cow urine application on the growth and uptake of nutrients of Indian mustard

In vitro studies of inhibitory activity of plant extracts and cow urine on mycelial growth of stem rot, Sclerotimoryzae of rice

Bio-inspired synthesis of catalytically and biologically active palladium nanoparticles using Bos Taurus urine

Evaluation of ghee based formulation for wound healing activity

Composition and Factors Affecting Quality of Bovine Colostrum: A

Plant growth promoting bacteria from cow dung based biodynamic preparations

Anti-inflammatory and anticancer activities of water-soluble peptide extracts of buffalo and cow milk Cheddar cheeses

Invoking 'Hindu'Ayurveda: Communalisation of the late colonial Ayurvedic discourse

Chemopreventive potential of cow urine against 7, 12 dimethyl benz (a) anthracene-induced skin papillomasgenesis in mice

Use of rhizobacteria and mycorrhizae consortium in the open field as a strategy for improving crop nutrition, productivity and soil fertility

Milk Containing A2 β-Casein ONLY, as a Single Meal, Causes Fewer Symptoms of Lactose Intolerance than Milk Containing A1 and A2 β-Caseins in Subjects with Lactose Maldigestion and Intolerance: A Randomized, Double-Blind

Bioremediation of pharmaceuticals, pesticides, and petrochemicals with gomeya/cow dung ISRN Pharmacology

Chemotherapeutic potential of cow urine: A review

Study on cow ghee versus soybean oil on 7, 12-dimethylbenz (a)-anthracene induced mammary carcinogenesis & expression of cyclooxygenase-2 & peroxisome proliferators activated receptor-γ in rats

Panchgavya and cow products: A trail for the holy grail

Physical, microbial and biochemical composition of bio-pesticides based on cow urine and dung with medicinal plants

Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats

Growth and yield response of rice (Oryza sativa) to graded doses of nutrients and foliar spray of cow urine

Clinical trial of go-mutra (cow's urine) in obesity management

In vitro evaluation of cow urine and buttermilk against three major soil borne pathogens of soybean

Crop losses due to diseases and their implications for global food production losses and food security

The global burden of pathogens and pests on major food crops

Effect of different organic inputs on biological properties of soil, yield and quality of crops under certified organic farms in Nagpur district of Maharashtra

Lactose and lactose derivatives as bioactive ingredients in human nutrition

Nutritional and health attributes of milk and milk imitations

Actinobacteria from Cow Feces: Isolation, Identification and Screening for Industrially Important Secondary Metabolites

Efficiency of cow dung based vermicompost on seed germination and plant growth parameters of Tagetes erectus (Marigold)

Evaluation of Milk Colostrum Derived Lactoferrin of Sahiwal (Bos indicus) and Karan Fries (Cross-Bred) Cows for Its Anti-Cancerous Potential

Induction of neurotoxicity by organophosphate pesticide chlorpyrifos and modulating role of cow urine

Antiobesity potential of fresh cow urine and its distillate-a biomedicine for tomorrow

Bioethanol production from halophytes of Thar Desert: A "green gold

Effects of conventional milk versus milk containing only A2 β-casein on digestion in Chinese children: a randomized study

Comparative antioxidant activity, proteolysis and in vitro α-amylase and α-glucosidase inhibition of Allium sativum-yogurts made from cow and camel milk

Efficacy of aqueous and cow-urine based biopesticides against Phytophthora nicotianae var. parasitica causing buckeye rot of tomato

Anti-urolithiatic effect of cow urine Ark on ethylene glycol-induced Renal Calculi

A comparative study on chronic administration of Go Ghrita (cow ghee) and Avika Ghrita (ewe ghee) in albino rats

Malnutrition in the elderly and its effects on bone health-A review

Effect of nitrogen levels and cow urine on soil N status, growth and yield on paddy

A comparison of the nutritional value of cow's milk and nondairy beverages

Anti-diabetic effect of fermented milk containing conjugated linoleic acid on type II diabetes mellitus

Prospects of Organic Farming as Financial Sustainable Strategy in Modern Agriculture

A cross comparison between Ayurvedic etiology of Major Depressive Disorder and bidirectional effect of gut dysregulation

Cellulose nanoparticles encapsulated cow urine for effective inhibition of pathogens

Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns

Phosphorus solubilization by thermotolerant Bacillus subtilis isolated from cow dung microflora

Clinical and haematological changes induced by chlorpyrifos and amelioration by cow urine distillate in broilers

Comparative evaluation of feeding effects of A1 and A2 cow milk derived casein hydrolysates in diabetic model of rats

A critical review on global trends in biogas scenario with its up-gradation techniques for fuel cell and future perspectives

Milk and dairy products: good or bad for human health? An assessment of the totality of scientific evidence

Use of native local bio resources and cow urine for the effective management of post-harvest diseases of apples in northwest himalayan states of India

Impact of bio-inoculants and bio-formulations on growth and yield of turmeric (Curcuma longa)

Dairy products and health: recent insights

Sustainable livestock systems to improve human health, nutrition, and economic status

Microbial degradation of petroleum hydrocarbons

Novel Gomutra (cow urine) mediated synthesis of silver oxide nanoparticles and their enhanced photocatalytic, photoluminescence and antibacterial studies

Polycyclic aromatic hydrocarbons and heavy metals in urban environments: Concentrations and joint risks in surface soils with diverse land uses

Therapeutic uses of animal biles in traditional Chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review

Dietary guidelines for Chinese residents comments and comparisons

Speciation of heavy metals and bacteria in cow dung after vermicomposting by the earthworm, Eisenia fetida

Dairy in Human Health and Disease Across the Lifespan

The double burden of malnutrition: aetiological pathways and consequences for health. The Lancet

Bioassay studies on the efficacy of cow urine based natural formulations on preference, fecundity and mortality of mustard aphid, Lipaphis erysimi (Kalt.)

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