key: cord-0898468-90ftbg94 authors: O’Flaherty, Roisin; Opdenakker, Ghislain; Clausen, Henrik; Gerardy-Schahn, Rita; Kieda, Claudine; Reis, Celso A; Rudd, Pauline M; Sadrieh, Azita; Axford, John title: Meeting report on 14(th) Jenner Glycobiology and Medicine Symposium: glycobiology in immunology, medicine, and clinical practice date: 2022-02-12 journal: Glycobiology DOI: 10.1093/glycob/cwac006 sha: 808f460c932bb711dfa585e4f77feb3660d834e8 doc_id: 898468 cord_uid: 90ftbg94 nan The 14 th Jenner Glycobiology and Medicine Symposium took place at the Rega Institute, KU Leuven, in the beautiful city of Leuven, Belgium, last October 2021 (Fig. 1) . The Jenner Glycobiology and Medicine symposia were the first and main international multidisciplinary conferences set up to examine the relevance of glycobiology to immunology, medicine, and clinical practice. The goal of the 14 th meeting was to continue to provide a free international forum for researchers to disseminate current leading-edge studies in the novel and classic fields of glycobiology, glycoimmunology, and glycomedicine. This year's Jenner XIV Symposium was a hybrid event, with most participants and speakers attending virtually through a Zoom platform and only a small collection of in-person audience members. These comprised the chairs for the sessions and 1 invited speaker working in Belgium. Traditionally, this conference was held as an in-person event prior to this meeting. Going forward, we plan to maintain the hybrid format with in-person and online attendance to facilitate an inclusive symposium with full recording and global accessibility for all. Across the globe, from Ireland to Brazil, a mixture of early career researchers, more established academics, and veteran investigators spoke of their cutting-edge research across 4 different sessions: "Innate and Adaptive Immunity," "Glycosylation and Glycan Recognition," "Translational Glycobiology," and an interview-style session, "An interview with Sir Greg Winter." Over 200 attendees tuned in virtually at different stages of the day. The symposium directed the audience members to major recent achievements in the field of glycoscience, and speakers described major technological advancements in fields such as atomic force microscopy and chemical editing tools (Koehler et al. 2019; O'Leary et al. 2021) ; novel insights into the role of glycans and binding partners in innate, and adaptive immunity, including glycosaminoglycans, glycoproteins, galectins, and O-glycopeptidases (Salanti et al. 2015; McCarthy et al. 2018; Madsen et al. 2020; Cagnoni et al. 2021; Pluvinage et al. 2021) ; and the effects of modifications, such as acetylation or sulfation (Baumann et al. 2015) and the role of glycans in Covid-19, including viral attachment and animal studies (Sanchez-Felipe et al. 2021; Harbison et al. 2022) and their clinical and translational applications (Winter et al. 1994) ; and the introduction to and description of a new class of molecules (glycoRNA) was described (Flynn et al. 2021) . A quiet respect and homage were paid to early contributions to the field. Born through the works of Prof. Raymond Dwek (University of Oxford) and Prof. Ivan Roitt (University College London) in the 1980s, spurred on from early discoveries made in the late 19 th century by Prof. Emil Fischer, the field of glycoscience has since flourished and the respect and enthusiasm to those that came before were evident from all speakers. A link to the recorded event can be found at: https:// youtu.be/BFc9zSOvG7s. The next meeting-The 15 th Jenner Glycobiology and Medicine Symposium-will be hosted by Celso Reis at the Institute for Research and Innovation in Health, University of Porto (www.i3s.up.pt) in the city of Porto, Portugal, and we welcome students and staff with an interest in glycoscience in medicine and translational science. 9-O-acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8 + ; regulatory T cells Small RNAs are modified with N-glycans and displayed on the surface of living cells Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S Glycanmediated enhancement of reovirus receptor binding An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles Glycosylation repurposes alpha-1 antitrypsin for resolution of communityacquired pneumonia Chemical editing of proteoglycan architecture Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis Targeting human cancer by a glycosaminoglycan binding malaria protein A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate Making antibodies by phage display technology The organizers thank the Royal Society of Medicine for the successful collaboration, the local organizing team at KU Leuven, and the New-castle Fighters Fighters and the Rega Foundation (Rega Stichting VZW, Belgium), KU Leuven, for sponsoring the event. None declared.