key: cord-0894800-7iu8l9zh
authors: Zandi, Milad; Soltani, Saber
title: Role of hemagglutinin‐esterase protein in SARS‐CoV‐2 infection?
date: 2021-08-15
journal: Cell Biol Int
DOI: 10.1002/cbin.11683
sha: f2bba58ac4ff669242862473af682ab2ba3631ee
doc_id: 894800
cord_uid: 7iu8l9zh

nan

In a published mini-review article in Cell Biology International, the authors considered hemagglutinin-esterase (HE) as a structural protein of SARS-CoV-2 which has roles in the entry and release processes of virus (Tantuoyir & Rezaei, 2020) . Coronaviruses are divided in four genera including alpha-, beta-, gamma-, and deltacoronavirus (Yang & Leibowitz, 2015) . The five subgenera are recognized within the genus beta-coronavirus (Yang & Leibowitz, 2015) . SARS-CoV-2 as a beta-coronavirus in lineage B causes COVID-19 (Letko et al., 2020) . It encodes four structural proteins: (1) the spike-surface glycoprotein, (2) the small envelope protein, (3) the membrane glycoprotein, and (4) the nucleocapsid protein, also several nonstructural proteins (Yin, 2020) ; however, other betacoronaviruses in lineage A such as HCoV-OC43, HCoV-HKU1, BCoV, and MHV encode HE (Yang & Leibowitz, 2015) . As a result, according to evidence, the genome of SARS-CoV-2 lacks the HE gene, therefore, HE cannot have a role in SARS-CoV-2 replication.

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