key: cord-0889692-m98qisld authors: Goldman, Ran D.; Yan, Tyler D.; Seiler, Michelle; Parra Cotanda, Cristina; Brown, Julie C.; Klein, Eileen J.; Hoeffe, Julia; Gelernter, Renana; Hall, Jeanine E.; Davis, Adrienne L.; Griffiths, Mark A.; Mater, Ahmed; Manzano, Sergio; Gualco, Gianluca; Shimizu, Naoki; Hurt, Thomas L.; Ahmed, Sara; Hansen, Matt; Sheridan, David; Ali, Samina; Thompson, Graham C.; Gaucher, Nathalie; Staubli, Georg title: Caregiver willingness to vaccinate their children against COVID-19: cross sectional survey date: 2020-10-10 journal: Vaccine DOI: 10.1016/j.vaccine.2020.09.084 sha: 9f6d6344e0486f96115199987f912cb137b6d24c doc_id: 889692 cord_uid: m98qisld Background More than 100 COVID-19 vaccine candidates are in development since the SARS-CoV-2 genetic sequence was published in January 2020. The uptake of a COVID-19 vaccine among children will be instrumental in limiting the spread of the disease as herd immunity may require vaccine coverage of up to 80% of the population. Prior history of pandemic vaccine coverage was as low as 40% among children in the United States during the 2009 H1N1 influenza pandemic. Purpose To investigate predictors associated with global caregivers’ intent to vaccinate their children against COVID-19, when the vaccine becomes available. Method An international cross sectional survey of 1541 caregivers arriving with their children to 16 pediatric Emergency Departments (ED) across six countries from March 26 to May 31, 2020. Results 65% (n = 1005) of caregivers reported that they intend to vaccinate their child against COVID-19, once a vaccine is available. A univariate and subsequent multivariate analysis found that increased intended uptake was associated with children that were older, children with no chronic illness, when fathers completed the survey, children up-to-date on their vaccination schedule, recent history of vaccination against influenza, and caregivers concerned their child had COVID-19 at the time of survey completion in the ED. The most common reason reported by caregivers intending to vaccinate was to protect their child (62%), and the most common reason reported by caregivers refusing vaccination was the vaccine’s novelty (52%). Conclusions The majority of caregivers intend to vaccinate their children against COVID-19, though uptake will likely be associated with specific factors such as child and caregiver demographics and vaccination history. Public health strategies need to address barriers to uptake by providing evidence about an upcoming COVID-19 vaccine’s safety and efficacy, highlighting the risks and consequences of infection in children, and educating caregivers on the role of vaccination. followed by an open-ended question "Why?" or "Why not?", with a free text box. The description of each response was categorized into themes using an inductive approach by one 195 author and reviewed for completeness by another author. The entirety of each response was analyzed 196 and if more than one sentiment was expressed in the caregiver's description, the individual response 197 was coded to multiple themes. Free text responses that were blank were categorized as no comment. The COVID-19 vaccine development landscape Covid-19: What do we know so far about a vaccine? Final estimates for 2009-10 seasonal Influenza and 392 Influenza A (H1N1) 2009 monovalent vaccination coverage -United States Factors in vaccination intention against the pandemic influenza A/H1N1. Eur 395 Likely uptake of swine and seasonal flu vaccines among 397 healthcare workers. A cross-sectional analysis of UK telephone survey data When a COVID-19 vaccine is ready, will we all be ready for it? Int 400 Vaccine hesitancy: an overview Planning for a COVID-19 vaccination program Fauci says COVID-19 vaccine may not get US to herd immunity if too many people 406 refuse to get it Exploring Lessons Learned from a Century of Outbreaks: 410 Readiness for 2030 Factors associated with uptake of vaccination against 413 pandemic influenza: A systematic review Healthcare workers as parents: Attitudes toward vaccinating their 416 Factors associated with parental 417 acceptance and refusal of pandemic influenza A/H1N1 vaccine in Turkey Public perceptions of COVID-19 in Australia: perceived risk, knowledge, 420 health-protective behaviours, and vaccine intentions Determinants of COVID-19 vaccine acceptance in Saudi Arabia: a 422 web-based national survey Hesitancy towards a COVID-19 vaccine and 424 prospects for herd immunity The French public's attitudes to a future COVID-19 426 vaccine: the politicization of a public health issue Preparing for a COVID-19 vaccine: Identifying and 428 psychologically profiling those who are vaccine hesitant or resistance in two general population 429 samples Low acceptability of A/H1N1 431 pandemic vaccination in french adult population: Did public health policy fuel public 432 dissonance? The influence of altruism on influenza 434 vaccination decisions Factors influencing childhood influenza immunization Acceptance of vaccinations in pandemic outbreaks: 438 A discrete choice experiment Striking a balance between risk and protection: fathers' attitudes and 440 practices toward child injury prevention Acceptability of A/H1N1 442 vaccination during pandemic phase of influenza A/H1N1 in Hong Kong: population based cross 443 sectional survey Factors associated with 445 refusal of childhood vaccines among parents of school-aged children: A case-control study Underimmunization in Ohio's Amish: 448 Parental fears are a greater obstacle than access to care Mapping vaccine hesitancy -Country-specific 450 characteristics of a global phenomenon Multisystem Inflammatory Syndrome Related to 452 COVID-19 in Previously Healthy Children and Adolescents Associations between health communication behaviors, 455 neighborhood social capital, vaccine knowledge, and parents' H1N1 vaccination of their 456 children Understanding vaccine hesitancy 458 around vaccines and vaccination from a global perspective: A systematic review of published 459 literature Vaccine beliefs of parents who oppose compulsory 461 vaccination Conceptualization, Methodology, Software, Formal Analysis, Investigation, Resources Writing -Original Draft, Writing -Review & Editing, Supervision Formal Analysis, Data Curation, Writing -Original Draft, Writing -Review & Editing Michelle Seiler: Investigation, Resources, Writing -Review & Editing Conceptualization, Methodology, Investigation, Resources, Writing -Review & Editing Conceptualization, Methodology, Investigation, Resources, Writing -Review & Editing 528 Julia Hoeffe: Investigation, Resources, Writing -Review & Editing Renana Gelernter: Investigation, Resources, Writing -Review & Editing Hall: Investigation, Resources, Writing -Review & Editing 534 Davis: Investigation, Resources, Writing -Review & Editing Sergio Manzano: Investigation, Resources, Writing -Review & Editing Gianluca Gualco: Investigation, Resources, Writing -Review & Editing 544 Naoki Shimizu: Investigation, Resources, Writing -Review & Editing Conceptualization, Methodology Matt Hansen: Investigation, Resources, Writing -Review & Editing Investigation, Resources, Writing -Review & Editing 554 Samina Ali: Investigation, Resources, Writing -Review & Editing Thompson: Investigation, Resources, Writing -Review & Editing Formal Analysis, Data Curation, Investigation, Resources, Writing -Original Draft