key: cord-0889601-1vzg7v3f
authors: de Sá Resende, Ayane; Matos de Oliveira, Yrna Lorena; Rodrigues de Moura, Tatiana; Martins-Filho, Paulo Ricardo
title: Potential role of Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in SARS-CoV-2 infection: First insights
date: 2021-03-26
journal: EXCLI J
DOI: 10.17179/excli2021-3581
sha: aa3d160bf1dd526e5c189204c2c67a3d87f5c618
doc_id: 889601
cord_uid: 1vzg7v3f

nan

have demonstrated that sTREM-1, in combination with respiratory rate, had the best prognostic accuracy for 30-day intubation/mortality in COVID-19 patients compared to CRP with 94 % sensitivity. In addition, severe COVID-19 patients presented significant higher levels of sTREM-1 at the initial phase of infection, thus, highlighting its relevance as useful triage tool to decide on outpatient management. High levels of sTREM-1 could be associated with either a virus-induced compensatory mechanism to counteract inflammatory process, or a host-induced mechanism to control tissue damage by attenuating downstream inflammatory signals (Roe et al., 2014) . Moreover, it has been found that sTREM-1 can be an early predictor of 28-day mortality in patients with ARDS (Lin et al., 2010) , which may occur as a severe complication in critically ill patients with COVID-19. Despite function of sTREM-1 has not been well established and there is an important gap in understanding the development and resolution of the immune response against SARS-CoV-2 infection, we hypothesized that TREM-1 and its soluble form may play a critical role in the hyperinflammatory response and poor outcomes in patients with COVID-19.

In summary, these first insights suggest that TREM-1 and its soluble form may play a pivotal role in the pathogenesis of SARS-CoV-2 infection. Further studies should investigate the clinical relevance of this inflammatory biomarker in COVID-19.

There is no funding source.

There is no conflict of interest.

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