key: cord-0889511-m08pptjd authors: Sugimoto, Tomohiro; Yorishima, Ai; Oka, Naoya; Masuda, Sho; Yoshida, Yusuke; Hirata, Shintaro title: Exacerbation of systemic lupus erythematosus after receiving mRNA‐1273‐based coronavirus disease 2019 vaccine date: 2022-02-22 journal: J Dermatol DOI: 10.1111/1346-8138.16327 sha: f10b833834586b7df1f1420b0926a834d93d89e6 doc_id: 889511 cord_uid: m08pptjd nan Externally injected mRNA induces type I interferon (IFN) production, especially IFNα and IFNβ. 1 The IFN signature in patients with SLE is thought to involve many IFN types, but type I IFN is considered to be the most important. Three decades of messenger RNA vaccine development Interferon pathway in SLE: One key to unlocking the mystery of the disease Exacerbation of subacute cutaneous lupus erythematosus following vaccination with BNT162b2 mRNA vaccine Induction and exacerbation of subacute cutaneous lupus erythematosus following mRNA-based or adenoviral vectorbased SARS-CoV-2 vaccination https://orcid.org/0000-0002-0968-9081Yusuke Yoshida https://orcid.org/0000-0002-0774-0509Shintaro Hirata https://orcid.org/0000-0002-2474-9943