key: cord-0885875-ub7j236c
authors: Myint, Aung; Jones, Trevor
title: Aung Myint and trevor Jones respond
date: 2020-07-11
journal: Vet Rec
DOI: 10.1136/vr.m2424
sha: e8a04961f565a05af18059296650d773d0e10d39
doc_id: 885875
cord_uid: ub7j236c

nan

antibodies on their surface are used, P multocida expressing the corresponding viral antigens will bind with these antibodies and become linked to the erythrocytes. Passive haemagglutination is, therefore, unlikely to be a confounding factor.

Furthermore, the expression of rabies lyssavirus glycoprotein by transformed P multocida was recently confirmed by western blot at the Department of Medical Research in Myanmar. It has also been confirmed that P multocida transformed with porcine reproductive and respiratory syndrome virus (PRRSV) contains a gene segment that encodes the PRRSV nucleocapsid protein. The sequence of this gene segment has been deposited in GenBank (accession number MT411898) and will be available online shortly.

The field vaccination of 9000 birds that we discussed previously (VR, 4/11 April 2020, vol 186, p 419) was a response to an immediate clinical problem and not an experiment. As such, there were no control groups with which to compare the vaccinated birds. However, the safety and efficacy of the IBV vaccine produced using our method had already been established. 2 As we pointed out previously, the evidence for this IBV vaccine being of value in the treatment of poultry in Myanmar is empirical, but it is independent and consistent over the past 25 years. However, we reiterate that any new vaccine produced using this method would need to be fully tested for safety and efficacy before being adopted for widespread use. 

Biased distribution of DNA uptake sequences towards genome maintenance genes

Efficacy of an inactivated avian infectious bronchitis vaccine