key: cord-0884207-kbcn8ot6
authors: Aung, Sidney; Vittinghoff, Eric; Nah, Gregory; Lin, Anthony; Joyce, Sean; Mann, N. Clay; Marcus, Gregory M.
title: Emergency activations for chest pain and ventricular arrhythmias related to regional COVID-19 across the US
date: 2021-12-14
journal: Sci Rep
DOI: 10.1038/s41598-021-03243-6
sha: 0893a86fd12ed1210e7bb8e687454f686315a4f5
doc_id: 884207
cord_uid: kbcn8ot6

Evidence that patients may avoid healthcare facilities for fear of COVID-19 infection has heightened the concern that true rates of myocardial infarctions have been under-ascertained and left untreated. We analyzed data from the National Emergency Medical Services Information System (NEMSIS) and incident COVID-19 infections across the United States (US) between January 1, 2020 and April 30, 2020. Grouping events by US Census Division, multivariable adjusted negative binomial regression models were utilized to estimate the relationship between COVID-19 and EMS cardiovascular activations. After multivariable adjustment, increasing COVID-19 rates were associated with less activations for chest pain and non-ST-elevation myocardial infarctions. Simultaneously, increasing COVID-19 rates were associated with more activations for cardiac arrests, ventricular fibrillation, and ventricular tachycardia. Although direct effects of COVID-19 infections may explain these discordant observations, these findings may also arise from patients delaying or avoiding care for myocardial infarction, leading to potentially lethal consequences.

Coronavirus disease 2019 , caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a significant threat to global health. The United States (US) currently leads the world in disease burden with over 33 million documented COVID-19 cases 1 . Although acute COVID-19 has been associated with a systemic inflammatory cytokine response that can directly contribute to coronary artery plaque rupture, activation of procoagulant factors, and hemodynamic changes that may predispose to ischemia, thrombosis, and therefore myocardial infarction [2] [3] [4] , several investigators have paradoxically reported marked declines in the incidence of myocardial infarctions during the COVID-19 pandemic [5] [6] [7] [8] [9] [10] . Further bolstering these findings, there have been decreasing cardiac catheterization laboratory activations and percutaneous coronary interventions over the same time period [10] [11] [12] .

The mechanistic explanations for these dramatic declines in myocardial infarctions remain unknown. One concern has been that those suffering symptoms of myocardial infarctions may be avoiding or postponing visits to a healthcare facility for fear of SARS-CoV-2 exposure, but it is difficult to fully elucidate such a phenomenon at the level of the general population. Consequently, we would anticipate a general decline in presentations to health care for symptoms of myocardial infarctions-namely chest pain.

One of the feared complications of myocardial infarction, particularly when left untreated, are ventricular arrhythmias and cardiac arrests. Studies localized to specific areas experiencing particularly high rates of COVID- 19 have demonstrated a rise in out of hospital cardiac arrest, although relationships with myocardial infarctions in those same areas and differences specifically in ventricular fibrillation and ventricular tachycardia have not been described [13] [14] [15] . In order to test the hypothesis that increased rates of COVID-19 would be simultaneously associated with a decline in emergency medical services (EMS) activations for chest pain and myocardial infarction with a concomitant rise in activations for cardiac arrests and malignant ventricular arrhythmias, we sought to characterize patterns of each of these phenomena in relationship to SARS-CoV-2 infections throughout the US. www.nature.com/scientificreports/

The relative populations and unadjusted incidence rates at baseline for each of the cardiovascular outcomes of interest prior to the pandemic within each of the 9 US Census Divisions are shown in Table 1 .

After adjustment for calendar day of week, calendar month, and US Census Division, there was a significant decrease in chest pain events with increasing COVID-19 rates (RR 0.67, 95% CI 0.63-0.70, p < 0.001; Fig. 1 ). There was also a significant decrease in NSTEMI events with increasing infections (RR 0.16, 95% CI 0.10-0.26, p < 0.001). No statistically significant relationships between the rates of STEMIs and rates of COVID-19 were detected (RR 1.14, 95% CI 0.96-1.34, p = 0.13).

After adjustment for the same covariates and over the same time period, there was a significant increase in cardiac arrest with increasing COVID-19 (RR 1.51, 95% CI 1.36-1.68, p < 0.001; Fig. 1 ). Similarly, COVID-19 rates were associated with significant increases in ventricular fibrillation (RR 1.47, 95% CI 1.23-1.77, p < 0.001) and ventricular tachycardia (RR 1.34, 95% CI 1.16-1.56, p < 0.001).

After adjustment for the same covariates, rates of COVID-19 were associated with significant decreases in rate differences for chest pain and NSTEMI (Table 2 ) along with significant increases in rate differences for cardiac arrest, ventricular fibrillation, and ventricular tachycardia (Table 3 ) and these findings were seen consistently within each US Census Division (Fig. 2) . Table 1 . Pre-pandemic incidence rates per 10,000 person-years by US Census Division from January 1, 2020 to January 31, 2020. NSTEMI non-ST-elevation myocardial infarction, STEMI ST-elevation myocardial infarction, VF ventricular fibrillation, VT ventricular tachycardia. www.nature.com/scientificreports/ In sensitivity analyses excluding all cases with EMS impressions for fever, sepsis, pneumonia, respiratory distress, or respiratory failure, none of the results were meaningfully different (Fig. 3 , Supplementary Tables 1-3 ).

In this national sample, as COVID-19 rates rose, chest pain and NSTEMI cases fell. No statistically significant relationship between COVID-19 rates and STEMI was observed. However, simultaneous with these phenomena, cardiac arrests and cases of both ventricular fibrillation and ventricular tachycardia each significantly increased concomitant with an increasing incidence of COVID-19.

Our findings largely fit with previous reports describing a decreasing incidence of myocardial infarctions during the pandemic [5] [6] [7] [8] [9] [10] . Unlike some studies limited to smaller regions of the US reporting substantial declines in STEMI, we did not observe a similar statistically significant relationship in this national evaluation. Interestingly, previous investigators have described a larger magnitude in reductions in NSTEMI than STEMI associated with the pandemic 6-10 , consistent with our results.

The reasons for the differential relationships between STEMI and NSTEMI as well as the general trends favoring reductions in these outcomes remain unclear. Indeed, COVID-19 is associated with coronary artery plaque rupture 2-4 and has been implicated as a primary cause of myocardial infarctions in some cases 16, 17 . It is possible there is some generalized effect related to the pandemic, perhaps related to shelter-in-place orders, that has resulted in an overall reduced propensity to myocardial infarction.

An alternative explanation is that there is no true reduction in myocardial infarctions, but that instead these studies as well as our current analysis all suffer from under-ascertainment because we are all relying on Table 2 . Rate differences by US Census Division for chest pain, NSTEMI, and STEMI. Rate differences represent differences in number of outcomes per 10,000 person-years for each increase of 10,000 SARS-CoV-2 infections. CI confidence interval, NSTEMI non-ST-elevation myocardial infarction, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, STEMI ST-elevation myocardial infarction. www.nature.com/scientificreports/ myocardial infarction patients seeking medical attention and being "counted". The current study focused solely on EMS activations for outcomes such as myocardial infarctions, and thus does not reflect the "true" rate of these events occurring in the population. COVID-19-related fear, specifically the prospect of becoming infected (and then perhaps infecting loved ones) may reduce visits to healthcare facilities [18] [19] [20] and delay care for myocardial infarctions 21 . Given the greater severity of STEMI, usually with more pronounced symptoms that may be more difficult to ignore or minimize, it appears plausible that a general reluctance to seek medical attention due to fear www.nature.com/scientificreports/ of COVID-19 may disproportionately affect those experiencing NSTEMI, fitting with the discrepant observations between SARS-CoV-2 related to STEMI and NSTEMI as others, and now we, have observed. If in fact the true incidence of NSTEMI was not decreasing, but instead individuals suffering from NSTEMI were simply not presenting to clinical attention, we would anticipate less ambulance calls for chest pain as demonstrated in the current study. Indeed, there is evidence that EMS activations in general have decreased across the United States during the early pandemic 22 , indicating that this is a broad phenomenon. Furthermore, one might expect to observe increases in the adverse events that would result from untreated myocardial infarctions. If indeed the suppression of healthcare utilization due to COVID-19-related concern was operative, presumably only the most severe and consequential events would result in those same patients ultimately seeking medical attention.

And indeed, during this same time period, despite the apparent decrease in chest pain and NSTEMI, we observed significant increases in cardiac arrests, ventricular fibrillation, and ventricular tachycardia with rising rates of SARS-CoV-2 infections. It is possible that direct effects related to the virus also played a role here. Those hospitalized with severe COVID-19 have been shown to experience a substantially increased rate of lethal ventricular arrhythmias [23] [24] [25] . There are various potential mechanisms linking COVID-19 to arrhythmogenesis including hypoxia, myocarditis, abnormal host immune response, myocardial ischemia, myocardial strain, electrolyte derangements, intravascular volume imbalances, and drug sides effects 26 . Cardiac MRI has also revealed myocardial delayed enhancement indicative of scar in large proportions of COVID-19 patients 27,28 , potentially providing a cardiac substrate particularly prone to ventricular arrhythmias and cardiac arrest. However, one can argue that the scale of the increases in the number of the outcomes observed in the current national study is too large for these changes to be primarily attributable to the virus itself. Furthermore, there is evidence that atrial arrhythmias, not a focus of the current study, are the most common cardiac arrhythmia observed in COVID-19 patients 29, 30 . It is difficult, if not impossible, to glean effects directly related to viral infection from those that may have occurred due to untreated myocardial infarctions, and a combination of both may also be present. Of note, in our sensitivity analyses excluding primary EMS impressions of respiratory or infectious phenomena occurring in the EMS activations, none of our findings were meaningfully changed.

Several limitations of the current study should be acknowledged. Given the ecologic study design, there is the risk for the "ecological fallacy", wherein we must acknowledge that aggregated population data may not accurately reflect purported mechanisms or intentions at the individual level. However, inferring the nature of the effects of interest in the current study required an assessment of particularly large numbers of people over heterogenous and broad geographic regions, making an ecologic study design appropriate for the current circumstances. Because geographic identifiers below US Census Division were not available for public use in the NEMSIS dataset, we were unable to capture differences at the state, county, or city level that may yet be important. However, absent meaningful interactions related to these more granular locations and the outcomes studied, we do not believe this limitation should have created spurious false positive results. We relied on the judgment and experience of EMS personnel to correctly report chest pain, identify myocardial infarctions, and interpret electrocardiograms and physical examination results (such as the lack of a pulse) to determine the diagnoses of interest. Given that patients with myocardial infarctions may present with symptoms other than chest pain, the observed decline in chest pain associated with increasing COVID-19 rates may have been due to EMS personnel reporting disproportionately more concurrent symptoms such as shortness of breath due to the impact of the ongoing COVID-19 pandemic. While evidence suggests that EMS personnel are generally accurate in identifying STEMIs 31-34 , the accurate diagnoses of NSTEMI is more nuanced and therefore may be more prone to error. While distinguishing ventricular tachycardia from supraventricular tachycardia can be difficult, diagnoses of ventricular fibrillation and cardiac arrest clearly fall within the EMS personnel's area of expertise. Regardless, it would appear unlikely that EMS personnel nationally-and within each separate US Census Division alone-would both be less likely to make a diagnosis of NSTEMI and yet more likely report diagnoses of cardiac arrest, ventricular fibrillation, and ventricular tachycardia as rates of SARS-CoV-2 changed in their region. And finally, chest pain, a subjective symptom that clearly decreased with SARS-CoV-2 rates, is essentially defined by the complaint offered by the patient without substantial skill required of the evaluating EMS personnel.

In conclusion, regional COVID-19 rates were associated with a decline in EMS activations for chest pain and NSTEMI along with a simultaneous rise in activations for cardiac arrests and malignant ventricular arrhythmias. Although effects of SARS-CoV-2 infections may explain these discordant observations, these findings may also arise from patients delaying or avoiding care for myocardial infarction, leading to potentially lethal consequences. Public health interventions aimed at reinforcing the need to seek appropriate care for suspected myocardial infarctions, especially in the highest risk patients, should be pursued. While the prevention of contracting and transmitting COVID-19 is important, plans and resources must also be in place to reduce the impact on the timely diagnosis and treatment of other serious conditions.

Study design. We conducted an ecological study to investigate the association between rates of COVID-19 and EMS activations for chest pain, myocardial infarction, cardiac arrest, and malignant ventricular arrhythmia between January 1, 2020 and April 30, 2020 across the US. The study period was chosen given that the first SARS-CoV-2 infections were recorded in January and continued until the end of the most recent data for EMS activation was available. The period beginning in March corresponds to the timing of the first major surge of SARS-CoV-2 infections in the US 1 . www.nature.com/scientificreports/ We abstracted the daily number of events for chest pain, non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarctions (STEMI), cardiac arrests, ventricular fibrillation, and ventricular tachycardia from the National Emergency Medical Services Information System (NEMSIS) database. NEMSIS is a national EMS registry that includes standardized patient care records submitted by over 10,000 EMS agencies across 47 states and territories in near real-time 35 . Most states require all EMS-related activations to be documented in NEMSIS. Additional information regarding NEMSIS and its submitting agencies can be obtained from the NEMSIS Technical Assistance Center and from previous studies that have utilized the NEMSIS database [36] [37] [38] . Diagnoses were recorded during an event by EMS personnel based on symptoms, physical examination (such as whether a pulse was detected), and electrocardiographic tracings. Geographic location for each event was aggregated into each of the nine US Census Divisions (https:// www. ncdc. noaa. gov/ monit oring-refer ences/ maps/ us-census-divis ions. php). Requests to access the data can be made through the NEMSIS registry after submitting a proposal: https:// nemsis. org/ using-ems-data/ reque st-resea rch-data.

We used epidemiological data from the Johns Hopkins University Center of Systems Science and Engineering COVID-19 dashboard to retrieve information regarding SARS-CoV-2 infections by location across all US states 1, 39 . State-level counts of SARS-CoV-2 infections were aggregated into their respective US Census Divisions to match the NEMSIS outcomes data. We used 2019 US Census data to obtain population denominators and calculate incidence rates.

Certification to use de-identified NEMSIS data was obtained from the University of California, San Francisco Institutional Review Board.

Statistical analysis. Negative binomial regression models were used to estimate the relationship between the daily rate of SARS-CoV-2 infections and the time-matched daily rate of EMS activations for chest pain, myocardial infarctions, cardiac arrest, and ventricular arrhythmias within the same US Census Divisions. We adjusted for calendar day of week, calendar month, and US Census Division in our models to derive the following adjusted measures of association. We derived estimates for incidence rate ratios (RR) for our outcomes, which are interpretable as relative increases in outcome rates per 10,000 person-years for each increase of 10,000 SARS-CoV-2 infections. We also derived estimates for rate differences, which are interpretable as differences in number of outcomes per 10,000 person-years for each increase of 10,000 SARS-CoV-2 infections. We performed sensitivity analyses after excluding all cases with signs or symptoms suggestive of active viral and/ or respiratory infection, including fever, sepsis, pneumonia, respiratory distress, and respiratory failure. Statistical analyses were performed using Stata, version 16 (College Station, TX, USA). Two-tailed p values < 0.05 were considered statistically significant.

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Requests to access the data can be made through the NEMSIS registry after submitting a proposal: https:// nemsis. org/ using-ems-data/ reque st-resea rch-data.

The National Emergency Medical Information System (NEMSIS) project was funded by the US Department of Transportation and National Highway Traffic Safety Administration (NHTSA).

The authors declare no competing interests.

The online version contains supplementary material available at https:// doi. org/ 10. 1038/ s41598-021-03243-6.Correspondence and requests for materials should be addressed to G.M.M.Reprints and permissions information is available at www.nature.com/reprints.Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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