key: cord-0882791-sonsrf5b authors: Franchini, Linda; Ragone, Nicola; Seghi, Federico; Barbini, Barbara; Colombo, Cristina title: Mental Health Services For Mood Disorder Outpatients In Milan During COVID-19 Outbreak: the experience of the health care providers at San Raffaele Hospital date: 2020-07-21 journal: Psychiatry Res DOI: 10.1016/j.psychres.2020.113317 sha: 083c334f893138f09bf9f62ee55e50328201f7fb doc_id: 882791 cord_uid: sonsrf5b The spread of COVID-19 throughout Italy, particularly Lombardy, led to adopt quarantine measures, known to exacerbate pre-existing psychiatric conditions. We described a telephone-based surveillance on 101 euthymic Mood Disorder outpatients in Milan by a non-standardized survey to evaluate reactions to lockdown measures and the presence of quarantine stressors. Frustration was the most represented quarantine stressor. Being jobless was significantly related to the presence of frustration, somatization, increased alertness, psychic anxiety and low mood; younger age to the presence of psychic anxiety, alertness and financial concerns. No recurrences were observed at the time of writing. The rapid spread of the novel Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-CoV-2) throughout the Italian country resulted in a tragic epidemic that led the Italian Government to impose emergency measures such as quarantine and social isolation. Quarantine is an unpleasant experience for those who undergo it and boredom can occasionally create dramatic effects, sometimes leading to suicide (Barbisch et al., 2015) . If domestic lockdown and social isolation have proved to be quite effective as physical containment for infections, it might prove risky from a psychological point of view due to the onset of distressing feelings such as uncertainty, fear, and despair (Poletti et al., 2018) . If environmental stressors may have negative consequences on individuals without a psychiatric history, their effect on patients with pre-existing mental disorders may become even more detrimental, eventually resulting in relapses or worsening of their mental condition (Hawryluck et al., 2004) . Considering that this is the first experience of such a collective social trauma in Italy, no analyses have focused on the potentially negative role of quarantine restrictions on mood disorder patients yet. Lombardy is the Italian region most severely affected by COVID-19 and, at the time of writing, the total number of positive cases in Milan reached 14,161 (data from Civil Protection); nationwide restrictions on travels and quarantine have resulted in difficult and impractical attending of regular psychiatric visits. To minimize the risk of infection arising from travels and social interactions, the Italian Ministry of Health indicated that outpatients in clinically stable conditions should be monitored using telemedicine approaches (e.g., phone, smartphone, laptop, or other devices) for the duration of the Italian lockdown (started from 9 th March 2020). Among these patients, it has been requested to evaluate the following parameters: 1) their physical conditions; 2) their knowledge of the pandemic situation; 3) their adherence and tolerance to quarantine restrictions; 4) occurrence of subclinical syndromes or new episodes of their psychiatric illness, to better understand their needs and concerns. The present report aims at describing the telephone-based mental illness surveillance on Mood Disorder patients attending the Mood Disorder Outpatient Center at San Raffaele Hospital in Milan, with the aid of a non-standardized survey to evaluate reactions to lockdown measures. The subjects affected by Major Depressive Disorder (MDD) or Bipolar Disorder (BP) who had a scheduled psychiatric visit during the Italian lockdown period (9 March-9 April 2020) at our Center, were contacted by phone to assess their clinical conditions. The inclusion criteria for our study were being in euthymic conditions according to the clinical judgment of the referring psychiatrist, having previously signed a written informed consent to participate in the ongoing observational study at our Hospital approved by the local ethical committee, and verbally agreeing to answer our questionnaire for clinical and research purposes. Scheduled patients underwent a telephone-based consultation by their reference psychiatrist concerning their physical (Temperature > 37.5, cough, cold, sore throat, dyspnea) and psychiatric conditions. The consultation was integrated with a short, non-standardized instrument created in the emergency of the current pandemic situation. The tool consisted in a questionnaire assessing the presence of items regarding emotional stressors (fear of infection, frustration due to restrictions, adequacy of supplies, adequacy of information, financial concerns), unpleasant experiences during the lockdown (sleep disturbances, mood or anxiety symptoms, increased dosage of anxiolytics and/or hypnotics) (Brooks et al., 2020) , and satisfaction with the questionnaire itself. Each item was rated as present, absent, or not answered. If present, the severity was rated on a Likert scale. Answers were reported in the medical record and were collected together with demographic and clinical data of interest (age, sex, duration of euthymia, duration of maintenance treatment, household composition, employment status, close contact with people affected by COVID-19, and personal history of COVID-19). Using the Stat-Soft STATISTICA 8.0 bivariate correlation analyses have been carried out to evaluate the association between clinical (diagnosis, euthymia and maintenance treatment duration), and demographic variables (age, sex , living alone, employment status) to quarantine stressor in order to identify predictive variables for multiple regression. At the time of writing quarantine has been going on for 37 days. One-hundred and one patients were screened for enrolment, all of which met the inclusion criteria. No missing data were reported. Our sample showed a mean age of 61.9±12 yrs, and an average period of euthymia of 30 months, with a mean long-term treatment period of 15.2±13 years. Fifteen out of 101 patients (14.8%) experienced COVID-19 among their relatives whereas none of them reported to have personally suffered from COVID-19. Furthermore, 32.6% lived alone and 66.4% were unemployed. Table 1 reports clinical and demographic characteristics of the sample, the percentage of each stressor reported and their significant correlations. Among our sample, 76% of patients reported frustration due to restrictions, 53.5% fears about infection, 45.5% financial concerns, 44.5% psychic anxiety, 40.6% low mood, 36.6% somatization, 31.6% increased alertness, 29.7% insomnia, 20.8% self-medication with sedatives, 2.9% inadequate supplies. Current age and employment status were the variable significantly correlated to quarantine stressors. According to multiple regression analysis, employment status was negatively significantly associated with frustration (beta -0.23), somatization (beta -0.34), alertness (beta -0.36), psychic anxiety (beta-0.20) and low mood (beta -0.21) ; age was negatively significantly associated with psychic anxiety (beta -0.27), financial concerns (beta -0.19) and alertness (beta-0.24). No patient reported symptoms of early mood disorder recurrence. All patients showed appreciation for this type of tele-monitoring. The purpose of our brief report is to describe the telephone-based mental illness surveillance on the quarantine effects in a sample of euthymic mood disorder patients who could not attend their scheduled psychiatric visit due to lockdown measures. The potential negative role of quarantine restriction on mood disorder patients depends on the high susceptibility to lifestyle-mediated disturbances of biological and social rhythms (Wang et al., 2019) . In this sense, social isolation, travel restrictions, and home confinement could predispose to an increased risk of affective recurrences. However, we have currently observed no recurrence of illness, supporting the crucial role of a sustained euthymia, reachable with a long-term maintenance treatment in Mood Disorders (Cava et al., 2005) . Frustration due to restrictions was the most represented stressor in our sample. This finding is not surprising in a long-lasting clinically stable sample and frustration could represent a normal and understandable response to an atypical and stressful situation such as the COVID-19. In fact, loss of usual routine and reduced social and physical contact have been linked to emotional responses, such as frustration, in a non-clinical population (Bai Y et al., 2004) . On the other hand, presence of frustration could be more harmful in mood disorder patients, considering that may lead to a worsening of the preexisting psychiatric disorders (Yao H, et al., 2020 , Lima CK et al., 2020 . In our sample, we found significant associations between unemployment and younger age as demographic variables and several quarantine stressors, including frustration. In particular being jobless was significantly related to the presence of frustration, somatization, psychic anxiety and increased alertness, while younger age to the presence of psychic anxiety and financial concerns. Lower household income and financial loss are known to be post-quarantine stressors and having a history of psychiatric illness was associated with experiencing anxiety and anger 4-6 months after quarantine (Jeong H et al., 2016) . In line with our results, our unemployed and younger patient might be at a higher risk for new recurrences and, therefore, they might benefit from a careful follow-up. We acknowledge that a non-standardized survey should be considered as a major limit, impeding the generalization of our observations. Nevertheless, considering the lack of standardized tools and the responsibility to maintain operational psychiatric care during this exceptional gravity situation, our experience can provide a useful contribution. We found very low rates of concerns regarding having inadequate information or supplies, suggesting that the emergency measures taken by the Italian authorities were appropriate and adequately released to the population. Finally, our experience suggested that telemedicine, although infrequently practiced in the Italian psychiatric setting until recently, might be considered as a valid ally against the clinical difficulties encountered during the COVID-19 pandemic, supporting patients in their regular psychiatric monitoring. Is there a case for quarantine? Perspectives from SARS to Ebola The psychological impact of quarantine and how to reduce it: rapid review of the evidence The experience of quarantine for individuals affects by SARS in Toronto SARS control and psychological effects of quarantine Mental health status of people isolated due to Middle east respiratory syndrome Impact of early and recent stress on white matter microstructure in major depressive disorder Circadian rhythm disruption and mental health Mar 6). Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China * r= -.1993 P<0.048; ° r= -.2392p<0.017; ** r= -.2042 p<0.043; *** r=-.3452 p<0.0001; § r= .2772 p<0.005 ;**** r=-.2052 p<0.042; °° r= -.2549 p<0.011; °°° r= -.3628 p<0.000; ç r= -2114 p<0.036