key: cord-0881999-wl8y97qq authors: Zipursky, Jonathan S.; Stall, Nathan M.; Silverstein, William K.; Huang, Qing; Chau, Justin; Hillmer, Michael P.; Redelmeier, Donald A. title: Alcohol Sales and Alcohol-Related Emergencies During the COVID-19 Pandemic date: 2021-03-02 journal: Ann Intern Med DOI: 10.7326/m20-7466 sha: 6dd5c59c5958d58b3625576e65664af7e2c45bde doc_id: 881999 cord_uid: wl8y97qq nan Background: During the coronavirus disease 2019 (COVID-19) pandemic, many regions across the world recommended stay-at-home orders, closure of public spaces, and physical distancing to reduce community transmission (1) . These measures contributed to isolation and anxiety, with recent surveys indicating increased subsequent consumption of alcohol (2) . Although drinking can lead to temporary relief of stress, alcohol misuse is a leading cause of mortality worldwide, contributing to about 3 million deaths annually (1) . Objective: To examine changes in alcohol sales and alcohol-related emergencies after the onset of the first wave of the COVID-19 pandemic. Methods and Findings: We examined alcohol sales and alcohol-related emergencies in Ontario, Canada (population, 14.7 million), from 1 July 2018 to 30 June 2020. A lockdown was declared on 17 March and ended on 24 July 2020, with the province ordering the closure of bars, restaurants, and other nonessential businesses soon thereafter. In contrast, alcohol stores were deemed essential and remained open. We obtained alcohol sales data in Canadian dollars (weekly, then aggregated to monthly) from the Liquor Control Board of Ontario, the government agency overseeing retail sales in the province for more than 99% of spirits, 83% of wine, and 31% of beer. We obtained data on monthly alcohol-related emergency visits from the Ontario Ministry of Health. Alcohol-related emergencies were grouped into 4 diagnostic subcategories: psychiatric, gastrointestinal, intoxication, and miscellaneous. We compared alcohol sales and alcohol-related emergencies during the first months of the COVID-19 pandemic (March to June 2020) with those in the corresponding months in the prior year (March to June 2019). This study was approved by the University of Toronto's research ethics board. Alcohol sales totaled $5.537 billion from 1 July 2019 to 30 June 2020, of which $1.885 billion was from March to June 2020. In contrast, sales totaled $5. Discussion: Substantial increases in alcohol sales during the COVID-19 lockdown were not mirrored by immediate absolute increases in alcohol-related emergencies, but visits for these outcomes decreased to a lesser extent than overall emergency department visits. Social isolation, financial strain, and anxiety may explain the observed pattern of increased alcohol sales during the lockdown (1). This is especially concerning given that decreases in hospital and community resources reduced access to mental health and addiction support services. Higher alcohol sales during the lockdown are worrisome because alcohol consumption can cause poor judgment, medical complications, and immune suppression. Alcohol also disrupts airway ciliary function, decreases recruitment of neutrophils into the alveoli, and weakens the pulmonary epithelial barrier (3). Consuming even moderate amounts of alcohol increases the risk for respiratory failure, which could worsen COVID-19 illness (3) . The absolute decline in total alcohol-related emergency visits may reflect a general reluctance to seek care or changes in drinking patterns (4). Despite increased alcohol consumption, some studies report shifts away from the harmful drinking that typically arises in social settings outside the home. In addition, the harmful effects of alcohol are often delayed; thus, increases in alcoholrelated health care visits may be anticipated in the future. A limitation of our study is that absolute numbers of all emergency visits may be substantially distorted because of an overall reluctance to visit hospitals during the lockdown (4). In addition, the true extent of long-term harm is difficult to establish, and further studies are needed to examine the delayed effects of increased alcohol consumption during the pandemic. Our findings suggest that increases in alcohol purchases early in the pandemic were not associated with immediate absolute increases in alcohol-related emergencies, although visit rates for these outcomes increased, a phenomenon similarly observed for mental health, overdose, and violence outcomes during the COVID-19 pandemic (5) . As such, clinicians should caution patients about the risks of alcohol consumption during the pandemic. In addition, public health measures to reduce the spread of COVID-19 should be matched by strategies to meet the treatment needs of patients with alcohol use disorders. Alcohol use and misuse during the COVID-19 pandemic: a potential public health crisis Changes in adult alcohol use and consequences during the COVID-19 pandemic in the US The effect of alcohol consumption on the risk of ARDS: a systematic review and meta-analysis The untold toll-the pandemic's effects on patients without Covid-19 Trends in US emergency department visits for mental health, overdose, and violence outcomes before and during the COVID-19 pandemic Acknowledgment: The authors thank Alex Kiss for statistical support and Maria Cusimano for comments on earlier versions of the manuscript; they were not compensated for their time. Reproducible Research Statement: Study protocol and statistical code: Available from the authors on request (e-mail, kamil.malikov@ ontario.ca), with the understanding that the computer programs may rely on coding templates or macros that are unique to the Ontario Ministry of Health and, therefore, are either inaccessible or may require modification. Data set: Not publicly available.