key: cord-0881217-xjg39i8m
authors: Sanfilippo, Filippo; La Rosa, Valeria; Astuto, Marinella
title: Micro-Thrombosis, Perfusion Defects and Worsening Oxygenation in COVID-19 Patients: A Word of Caution on the Use of Convalescent Plasma!
date: 2020-11-03
journal: Mayo Clin Proc
DOI: 10.1016/j.mayocp.2020.10.035
sha: 062990f9b3ec7c487a120229572b0b9e6a1c7482
doc_id: 881217
cord_uid: xjg39i8m

nan

To the Editor: Joyner et al. 1 Recently provided a safety update on the use of convalescent plasma (CP) in a population of 20.000 patients with coronavirus disease-19 . The results on the safety aspects, elegantly presented by the authors, may seem encouraging from many perspectives.

However, we would like to comment on an extremely important aspect when considering the use of CP.

Most of the attention on safety issues during administration of CP has been directed towards side effects unrelated to the clinical settings (i.e. infection, transfusion-related acute lung injury or transfusion associated circulatory overload) and "disease-specific" (such as viral enhancement). 

Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients

Pulmonary Embolism in Patients With COVID-19: Awareness of an Increased Prevalence

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations