key: cord-0879032-gztccifa
authors: Vendola, Nicoletta; stampini, Viviana; Amadori, Roberta; Gerbino, Martina; Curatolo, Annalisa; surico, Daniela
title: Vertical transmission of antibodies in infants born from mothers with positive serology to COVID-10 pneumonia
date: 2020-08-27
journal: Eur J Obstet Gynecol Reprod Biol
DOI: 10.1016/j.ejogrb.2020.08.023
sha: dc2a2678f2068a1712e11c2672815fa3c835bb74
doc_id: 879032
cord_uid: gztccifa

nan

To date there is no certainty if the mother transmits serological protection through the placenta. We describe two cases of mother with positive IGG on peripherical blood test, and the evidence IGG The second patient GP was admitted in our clinic on June the 2nd 2020, resulting positive to the serology for Covid 19 IGG (index 8,01) but negative on naso-pharyngeal swab. She was asymptomatic for Covid 19, without fever, cough, dyspnea and diarrhea. Her obstetrical history was uncomplicated. She delivered spontaneously after amniotic rupture. During the birth serological testing on umbilical cord, amniotic fluid and baby's peripheral blood was performed, and they resulted positive for Covid 19 IGG (index 7.66).

In our cases SARS-CoV-19 IgG were detected in the maternal serum, and specific antibodies were detected in neonatal blood serum samples with elevated concentrations, similar to the IgG concentrations of their respective mothers, despite the babies' throat swab were negative.

IgG is passively transferred across the placenta from mother to fetus, beginning at the end of the second trimester and reaches high levels at the time of birth 3 , while IgM is not usually transferred from mother to fetus because of its larger macromolecular structure.

Some studies have been published demonstrating the presence of IgM in the newborn, suggesting that the baby had developed the intrauterine infection and he had produced the IgM autonomously. The human fetuses has been found capable to produce immunoglobulines but half life of IgM is five days 4 .

These findings update the case series published by Zeng 5 adding two cases We underline the need of further studies to deepen the serological characteristics of infants whose mothers had been infected with SARS-CoV-2, and their immunity to the virus. 

Performance characteristics of the Abbott architect SARS-CoV-2IgG Assay and Seroprevalence in

Elevation of Cord over Maternal IgG Immunoglobulin: Evidence for an Active Placental IgG Transport

Serum IgM in Diagnosis of Infection in the Newborn

Antibodies in Infants Born to Mothers With COVID-19 Pneumonia