key: cord-0875540-dwrk0apt authors: Kay, Fernando; Abbara, Suhny title: The Many Faces of COVID-19: Spectrum of Imaging Manifestations date: 2020-02-14 journal: Radiol Cardiothorac Imaging DOI: 10.1148/ryct.2020200037 sha: 15f6041daf7b05abf42ec4e4a4df34a05042a8b8 doc_id: 875540 cord_uid: dwrk0apt nan The spotlight of this Radiology: Cardiothoracic Imaging issue exposes the wider spectrum of radiologic manifestations of the COVID-19 acute respiratory disease that can be encountered on images of the chest. On this issue, Ng et al (5) examine the clinical and radiologic presentation of 21 patients with confirmed COVID-19 from Chinese centers in Shenzhen and Hong Kong. They also put their findings into perspective and compare with imaging studies from other Chinese centers obtained by a systematic review of the emerging literature (6) (7) (8) (9) . The article demonstrates the spectrum of radiologic presentations and illustrates the growing role of CT in evaluation of patients with COVID-19 when compared to past coronavirus outbreak. The most common findings expected on chest imaging are ground-glass opacities or consolidation in a multilobar and peripheral distribution (5). However, despite the continuous crystallization of this general picture of COVID-19, the granular analysis reveals a plethora of imaging manifestations, which is perhaps more diverse than anticipated. This is reflected in the large number of case reports with very interesting aspects recently submitted to this journal. For example, Kong and Agarwal (10) report a series of three unrelated cases of COVID-19 pneumonia presenting with a spectrum of findings on chest radiograph and CT, varying from the commonly seen ground-glass opacities and consolidation, to patterns that include crazy paving and reversed halo, suggesting organizing pneumonia as the underlying mechanism of lung injury (11, 12) . In another report, Wu et al (13) show the temporal evolution on CT of a patient with COVID-19 infection, also presenting with radiologic findings resembling organizing pneumonia. It is noteworthy to mention that organizing pneumonia was described as the hallmark of another coronavirus infection outbreak occurring in 2012, with epicenter identified in Saudi pneumonia (6, 20) . As the disease outbreak affects a larger population each day, it is crucial to develop strategies for protecting those at increased risk for worse clinical outcomes. New data about the COVID-19 continues to emerge, and will, hopefully, facilitate the diagnostic and preventive measures for containing and minimizing the impacts of this international health emergency on public health. This focused issue of Radiology: Cardiothoracic Imaging seeks to raise awareness for this disease among the imaging community, illuminating the spectrum of disease under the microscope. As the picture becomes clearer, it is time for the scientific community to move to the next level, focusing efforts in elucidating the radiologic-pathologic correlation, determining potential imaging predictors of outcomes, and investigating the role of imaging for guidance of therapy. I n p r e s s Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle Novel Coronavirus(2019-nCoV) Situation Report -24 Novel Coronavirus (2019-nCoV) in the U Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet CT Imaging Features of 2019 Novel coronavirus (2019-nCoV) Emerging Coronavirus 2019-nCoV Pneumonia Chest Imaging Appearance of COVID-19 Infection Crazypaving" pattern at thin-section CT of the lungs: radiologic-pathologic overview From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, I n p r e s s organizing pneumonia, and acute fibrinous and organizing pneumonia Longitudinal CT Findings in COVID-19 Pneumonia: Case Presenting Organizing Pneumonia Pattern Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings Imaging of pulmonary viral pneumonia. Radiology COVID-19 Infection Presenting with CT Halo Sign The CT Halo Sign Spectrum of Chest CT Findings in a Familial Cluster of COVID-19 Infection Severe Acute Respiratory Disease in a Huanan Seafood Market Worker: Images of an Early Casualty Clinical Characteristics of 138 Hospitalized Patients With Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA