key: cord-0872036-hgpihlhp
authors: Moseley, Isabelle; Yang, Eric J.; Mathieu, Regine J.; Elco, Christopher; Massoud, Cathy M.
title: Wells’ syndrome as a presenting sign of COVID-19 in the setting of allergic rhinitis and iron deficiency anemia
date: 2022-03-03
journal: JAAD Case Rep
DOI: 10.1016/j.jdcr.2022.02.018
sha: 40d7e87df8a56a0d322456ff3eb65af27b29287c
doc_id: 872036
cord_uid: hgpihlhp

nan

Introduction characterized by urticarial plaques often admixed with papulonodules or vesiculobullae; systemic 25 features include fever, malaise, and arthralgias with peripheral eosinophilia in 50% of cases. 1 26 Wells' syndrome is thought to be a type IV hypersensitivity reaction; multiple implicated 27 triggers and associations include arthropod assault, infection, medication, hematologic disorders, 28 and solid organ malignancies. 1-4 Pathogenesis involves eosinophil degranulation, and histologic 29 correlations are identified. 1 We present a patient who experienced Wells' syndrome in response 30 to a novel trigger: COVID-19 infection.

A 51-year-old woman with a history of biopsy-proven Wells' syndrome, allergic rhinitis, and Clinicopathologic correlation rendered a diagnosis of Wells' syndrome secondary to arthropod 42 assault; oral prednisone taper achieved resolution. On re-presentation, the patient was afebrile, 43 normotensive, with mild tachycardia (106 bpm) and 100% oxygen saturation on room air. 

Wells' Syndrome Associated with Coxsackievirus A6 Infection

Wells syndrome