key: cord-0869247-7w8dsqiq
authors: Erard, Domitille; Villeret, Francois; Lavrut, Pierre-Marie; Dumortier, Jérôme
title: Autoimmune hepatitis developing after COVID 19 vaccine: presumed guilty?
date: 2021-12-15
journal: Clin Res Hepatol Gastroenterol
DOI: 10.1016/j.clinre.2021.101841
sha: 65fc8a3ca30cfcce6814ce9eeef39ed368fd7b33
doc_id: 869247
cord_uid: 7w8dsqiq

nan

This study did not receive any funding. Authors have no conflict of interest to declare. vaccination (1). In our patients, delay between vaccination and AIH onset was also short but one of the patient had had two doses of vaccine and this is consistent with reported case of AIH after influenza vaccination (2). In addition, age of our patients are older than in previous reported severe AIH, strongly suggesting that vaccination was the trigger for AIH development (3) . Two other cases of AIH post COVID 19 vaccination were reported suggesting that the association of COVID 19 vaccination and AIH is potentially not coincidental (4, 5) .

Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: Causality or casualty?

Development of autoimmune hepatitis after influenza vaccination; trigger or killer?

Early liver transplantation for corticosteroid non-responders with acute severe autoimmune hepatitis: The SURFASA score

Autoimmune hepatitis following sars-cov-2 VACCINE: MAY not be a casualty

Autoimmune hepatitis following COVID-19 Vaccination: true causality or mere association?

Diffuse hepatitis (a : HES X100), lobular and portal (black arrows). Portal and lobular intense lymphoplasmacytic infiltrate (c : HES X400) with interface hepatitis and hepatocyte necrosis (asterisk = acidophilic bodies)

We report here three case of severe AIH after SARS-CoV-2 vaccination whatever the type of vaccine. This should not discourage vaccination but may raise some awareness to diagnose and rapidly treat AIH since it can lead to liver failure.