key: cord-0868820-d2zyogct
authors: Zhang, Ting; Zhong, Sen; Cao, Wenzhai
title: COVID-19 and Comorbid Hypertension: Is ACE2 the Culprit?
date: 2020-08-25
journal: Prehospital and disaster medicine
DOI: 10.1017/s1049023x20001090
sha: 4211d27e3cad142371a51a1ee9d1207e8c422216
doc_id: 868820
cord_uid: d2zyogct

nan

TMPRSS2 and ACE2 in human myocardial and testicular samples were different and inconsistent by single RNA-seq. 8, 9 These results suggest there may be interactions between ACE2 expression cells and TMPRSS2 expression cells. Ziegler found that there are ACE2 and TMPRSS2 co-expression cells, a rare subset of epithelial cells, in respiratory tissues. 10 Whether ACE2 and TMPRSS2 are needed on the same cell or some proteases could activate SARS-CoV-2 S-protein to invade ACE2 singlepositive cells is still unclear. Therefore, as for the susceptibility of COVID-19 infections with hypertension patients, attention should also be paid to ACE2 and TMPRSS2 expression in the lung tissue and the interaction between them in order to make a comprehensive judgment.

In the future, single-cell sequencing-based technologies will be applied to study the expression level of ACE2 in alveolar type-2 cells of COVID-19 patients with hypertension with different stages of infection, as well as the association between ACEI drugs and ACE2, so as to clarify the role of ACE2 in COVID-19.

Clinical characteristics of coronavirus disease 2019 in China

Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region

Coronavirus disease 2019 (COVID-19) and cardiovascular disease: a viewpoint on the potential influence of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers on onset and severity of Severe Acute Respiratory Syndrome Coronavirus 2 infection

Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2

Risks of ACE inhibitor and ARB usage in COVID-19: evaluating the evidence

Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations

SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor

Myocyte specific upregulation of ACE2 in cardiovascular disease: implications for SARS-CoV-2 mediated myocarditis

Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes

SARS-CoV-2 receptor ACE2 is an interferonstimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues