key: cord-0866289-vc963k54 authors: Emmanouilidis, Sara; Hackney, Madeleine E.; Slade, Susan C; Heng, Hazel; Jazayeri, Dana; Morris, Meg E. title: Dance Is an Accessible Physical Activity for People with Parkinson's Disease date: 2021-10-22 journal: Parkinsons Dis DOI: 10.1155/2021/7516504 sha: 21ec4d1a674cb083272510adb4e8a6b30a0c0cc3 doc_id: 866289 cord_uid: vc963k54 OBJECTIVE: To evaluate the outcomes of face-to-face, digital, and virtual modes of dancing for people living with Parkinson's disease (PD). DESIGN: Systematic review informed by Cochrane and PRIMSA guidelines. Data Sources. Seven electronic databases were searched: AMED, Cochrane, PEDro, CINHAL, PsycINFO, EMBASE, and MEDLINE. METHODS: Eligible studies were randomised controlled trials (RCT) and other trials with quantitative data. The PEDro scale evaluated risk of bias for RCTs. Joanna Briggs Institute instruments were used to critically appraise non-RCTs. The primary outcome was the feasibility of dance interventions, and the secondary outcomes included gait, balance, quality of life, and disability. RESULTS: The search yielded 8,327 articles after duplicates were removed and 38 met the inclusion criteria. Seven were at high risk of bias, 20 had moderate risk of bias, and 11 had low risk of bias. There was moderately strong evidence that dance therapy was beneficial for balance, gait, quality of life, and disability. There was good adherence to digital delivery of dance interventions and, for people with PD, online dance was easy to access. CONCLUSION: Dancing is an accessible form of exercise that can benefit mobility and quality of life in people with PD. The COVID-19 pandemic and this review have drawn attention to the benefits of access to digital modes of physical activity for people living with chronic neurological conditions. Parkinson's disease (PD) is a debilitating and progressive condition that currently has no cure. People living with PD can experience movement disorders and nonmotor symptoms that compromise their levels of physical activity [1] and quality of life [2] [3] [4] [5] . Movement slowness [6] , balance impairment [7] , falls [8, 9] , and gait disturbance often occur [10] . ese movement disorders, coupled with anxiety, depression, or lethargy, can be major barriers to maintaining long-term engagement in physical activity [1] . Structured exercises and physical activities can assist people with chronic diseases to keep moving and to stay engaged in social activities and recreational sports [1] . One of the challenges for practitioners is keeping people with Parkinson's motivated to adhere to regular physical activities over long periods of time [1] . People typically live with PD for 7-25 years [11, 12] , and clinical guidelines recommend daily physical activities for at least 30-45 minutes per session [13] . For progressive conditions such as PD, it is recommended that a range of therapeutic exercises is available, to maintain long-term exercise adherence and compliance [1, 14] . ere is evidence that people in the early to midstages of Parkinson's can benefit from progressive resistance strength training [8, 15, 16] , cueing [10, 15] , aqua therapy [17] , physiotherapy [18, 19] , aerobic exercises [20] , Nordic walking [21] , community walking [22] , assisted cycling [23] , boxing [24] , and tai chi [25] . erapeutic dancing is another option, given that it is engaging and can be done in groups or individually [26] [27] [28] . Dancing for people with PD aims to improve movement, wellbeing, and quality of life, as well as social engagement and exercise capacity [29] [30] [31] [32] . Dance also allows for creative expression and can take the focus off the disease and onto movement to music and social connection [31, 33, 34] . A study by Dos Santos Delabary et al. [35] reported that dance sometimes has greater benefits for functional mobility and motor symptoms than usual care. Likewise, Shanahan et al. [36] noted that participation in dance can improve endurance, motor impairment, and balance for those with mild to moderate PD. Berti et al. [37] reported that adapted tango dance programs are an effective intervention for individuals with PD with a range of abilities and balance limitations. Given the need for people with Parkinsonism and related disorders to have a range of evidence-based exercise choices, the primary aim was to evaluate the outcomes of face-toface, online, and virtual modes of therapeutic dancing as an accessible physical activity for people living with PD. e outcomes of particular interest were balance, gait, disability, and quality of life. We conducted a systematic review of the literature following a priori methods. Two independent reviewers (SE, HH) were involved in the selection of studies into the review and two independent reviewers (SE, DJ) completed the data extraction to ensure that all relevant studies were identified, and that data were extracted reliably and consistently [38] . e review was informed by Cochrane guidelines and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist [39] . e search was conducted using seven electronic databases: AMED, Cochrane, PEDro, CINHAL, PsycINFO, EMBASE, and MEDLINE. e search terms included: Parkinson disease or Parkinson's disease or Parkinson * , movement disorders and dance therapy or dancing or dance based or danc * or foxtrot or tango or waltz or "Irish set" or ballroom or dance movement therapy or contemporary salsa or cultural and telerehabilitation or telemedicine or telehealth or tele or remote or online or web-based or virtual or in-person or pre-recorded or live or synchronous or asynchronous or partnered or on-partnered and quality of life or balance or gait or disability. e MEDLINE strategy was adapted to the other databases and search strategies are available on request. An example of the Medline search strategy is in Table 1 . e searches were conducted by a health sciences librarian up until June 2020, saved in each database, and downloaded into the bibliographic management software program Endnote [40, 41] . Search yields were combined into one Endnote library, and duplicates were deleted prior to application of the eligibility criteria to the titles. Inclusion and exclusion criteria were firstly applied to the titles to exclude studies that were clearly ineligible. We then applied the eligibility criteria to the titles and abstracts (SE, HH). Two reviewers (SE, HH) independently read in full the remaining articles to determine whether they met the eligibility criteria. A third reviewer (SS) was consulted to reach consensus if needed. Remaining discrepancies were resolved through consensus by two final reviewers (MM, MH) to determine the final included studies. e study designs included randomised controlled trials (RCT) and nonrandomised trials that contained data. We deliberately included both randomised and nonrandomised trials, to extend the findings of systematic reviews, which were confined to RCTs (e.g., [35] [36] [37] . e full text had to be available and accessible in English. Systematic reviews, meta-analyses, protocol papers, letters to the editor, conference posters, opinion pieces, and abstracts were excluded. Participants had to have a diagnosis of PD. Other chronic neurological, musculoskeletal, or respiratory conditions were excluded, as well as dementia and Alzheimer's disease. Individuals were at any stage of PD classified by the modified Hoehn and Yahr Scale [42] and living in residential care or the community. Adults of all ages, genders, and many cultures were included. Studies were included if they used dance as an exercise intervention or form for physical activity or physiotherapy. All genres of dance were eligible, including Irish-set dancing, tango, waltz, tap, jazz, salsa, ballroom, ballet, mixed genre, and creative dancing. Classes could be delivered partnered or nonpartnered, group or one to one and with or without music. e mode of delivery was in-person, digitally (also known as online), or using virtual tools. Online delivery was via platforms such as Zoom ® or Microsoft Teams ® . Some of the dance interventions were delivered by dance teachers and others were delivered using "virtual" tools such as Wii (Nintendo Inc., Japan) or Sony Play Station ® video game systems. e criteria for comparison or control interventions were any "usual care" or "usual physical activity" condition or any other therapeutic intervention. Studies were selected if they included baseline and after intervention outcomes for any of the following variables: gait, balance, movement, mobility, movement disorders, nonmotor symptoms, disability, participation, quality of life, wellbeing, or social participation. Feasibility studies were also reviewed. e PEDro scale was used to determine the risk of bias for RCTs [43] . PEDro was selected as it is a valid and reliable appraisal instrument for RCTs [44, 45] . Joanna Briggs Institute (JBI) instruments were used to critically appraise nonrandomised studies and to determine their risk of bias [46, 47] . Risk of bias assessments were completed independently by two reviewers (SE, SS), and consensus was reached by consultation with the research team (MM, MH). 2.1.6. Data Extraction. Reviewers (SE, DJ,) independently extracted data into a pretested spreadsheet under headings such as study, participant and intervention characteristics, and outcome data. e data were independently screened and confirmed (SS, MEM). Outcome data were extracted for short-, medium-, and long-term follow-up assessments when reported. For quantitative data, summary statistics were calculated. For the RCTs, the reported means and standard deviations were tabulated, and the Hedge's g, bias-corrected effect size (ES) index was used to estimate the effects of dancing compared to another intervention or no therapy [48] . In some cases, the ES was already reported as a standardized mean difference (SMD) or Cohen's d [49, 50] which we used. e Hedge's g and Cohen's d are similar; the Hedge's g tends to perform better with sample sizes lower than 20. Whenever possible, a 95% confidence interval (95% CI) was calculated around the SMD for an estimate of the range of intervention effects [51] . Median scores and interquartile ranges (IQR), reported by the study authors, were also tabulated [52] . To facilitate comparisons across studies, median scores were entered into SMD calculations as best estimates of mean scores [53] . For non-RCTs, within-group mean differences and change scores were reported and effect sizes calculated whenever possible. Of the initial yield of 17,122, there were 8,327 remaining after duplicates were removed. Screening of the articles was conducted by two independent reviewers (SE, HH) with 34 articles initially assessed for eligibility. A third reviewer (SS) was consulted to check the findings and reach consensus and 13 additional articles were added by members of the research team (MM, MH). From the articles read in full, 9 were excluded because they did not meet the eligibility criteria. Final consensus was reached in consultation with MM and MH, yielding a total of 38 articles. Figure 1 shows the PRISMA-compliant flowchart for selection of studies [39] . Of the included studies, 17 were RCTs [26, 27, 30, [54] [55] [56] [57] [58] [59] [60] [61] [62] [63] [64] [65] [66] [67] . One of these was a sequential RCT [66] , one was a quasi-RCT [67] , and one was an RCT with a crossover design [63] ( Table 2) . Of the trials, 21 had nonrandomised designs [28, [68] [69] [70] [71] [72] [73] [74] [75] [76] [77] [78] [79] [80] [81] [82] [83] [84] [85] [86] [87] , and one of these was a quasiexperimental study [81] . One used mixed methods design [82] for which quantitative data were extracted and analysed. Also, one was an exploratory trial [87] and there was an additional single case study [88] . (Table 2 ). e included studies ranged in sample size from 6 to 96 participants ( Table 2) . Only 3 studies included either telehealth [84] or technology-based interventions that included virtual reality dancing [57] or dance Google glass modules [73] . Dance interventions included tango [27, 28, 54, 55, 58, 59, 60-62, 64, 66, 68, 70, 72, 80, 82, 86] , Sardinian folk dancing [56] , Irish set dancing [26, 65] , waltz/foxtrot [55, 61] , ballet [85] , Brazilian Samba [83] , Zumba [71] , Qigong dance [63] , improvisation dance [79] , or mixed dance genres [27, 55, 62, 66, 67, 77, 78] , with three studies including home-based dance programs [27, 68, 76] . e duration of interventions ranged from two weeks to two years with frequency per week varying from once a week to daily. e intervention session length was usually 1 hour, although it ranged from 30 minutes to two hours. Method quality and risk of bias assessments were conducted for all studies. Table 3 shows that the risk of bias for five of the RCTs was high [54, 57, 59, 61, 66] . It was also high for two of the nonrandomised studies [72, 75] . In addition, 20 were at moderate risk of bias (eight RCTS, 12 nonrandomised studies) [26, 28, 30, 55, 56, 58, 65, 67, 69-71, 73, 74, 76-79, 84, 87, 88] and 11 were at low risk of bias (four RCTs, seven nonrandomised studies) [27, 62-64, 68, 81-83, 85, 86, 80] . For RCTs, blinding of the participants and therapists was generally not possible due to the nature of dance therapy. A large number of RCTs did not include intention to treat analysis [26, 30, 54-57, 59, 61, 65-67] , concealed allocation [30, [54] [55] [56] [57] [58] [59] [60] [61] 66] , or reporting of outcomes for more than 85% of participants at each time point [26, 54, 57, [59] [60] [61] [62] [65] [66] [67] . ese omissions increased the risk of bias (Table 3) . Non-RCTstudies were identified as having increased risk of bias as there was no control group [28, 68, 70-74, 75-80, 84, 87] , or they did not receive similar treatment or care [28, 68-75, 80, 81, 84, 87] , or they did not conduct a follow-up [69-72, 74-76, 83-85, 87] . Data analysis is presented in Tables 4 and 5 . Overall, the results showed moderate to large benefits from therapeutic dance for people with mild to moderate PD ( Table 4 ). RCTs demonstrated significant short-term benefits for balance with the Berg Balance scale (BBS) [30, 56, 57, [59] [60] [61] 67] , significant reduction in disability measured by the Unified Parkinson's Disease Rating Scale (UPDRS) [26, 30, 56, 59, 61, 62, 65, 67] , significantly improved mobility measured by Timed Up and Go (TUG) [56, 58, 59, 61] , significantly improved endurance measured by the 6 Minute Walk Test [56, 61] , significantly reduced gait freezing measured by the Freezing of Gait scale [59, 61, 65] , and significantly reduced depression measured by the Beck Depression Inventory [57] . Metaanalysis was not conducted due to intervention and outcome measure heterogeneity. e effects of dancing for PD reported in non-RCTs demonstrated end of intervention benefits for people with mild to moderately severe disease (Table 5) . ere were improvements in balance (BBS) [28, 72, 77, 80] , disability (UPDRS) [68, 72, 78, 80, 86] , mobility (TUG) [28, 72, 73, 75, 80] and Tinetti Mobility Scale [75] , depression [70, 83] , and quality of life [26, 68-70, 86, 87] . Key studies on digital delivery modes for dancing with PD (e.g., [57, 73, 84] ) showed that virtual technologies can be an accessible and beneficial method of physical activity for some people living with this chronic and progressive disease. is systematic review of the global literature showed that dancing for individuals with mild to moderately severe PD could be a beneficial and accessible form of physical activity for some people, whether delivered face-to-face or using an online telemedicine platform or "virtual dance" videogaming tools. e findings support mounting evidence that therapeutic dance can, in the short term, significantly improve balance, mobility, gait, disability, and quality of life in PD [26, 68, 70, 86, 87, 89] . Although the recruitment levels in the reviewed studies did not always meet clinical trial targets, attendance and adherence to dance classes were generally high. e duration of the dancing classes and session lengths varied, and improvements were seen in interventions running for two weeks [72] up to 2 years [54] . ere were significant improvements when session lengths ranged from 30 to 90 minutes per day. Although previous systematic reviews of dance for Parkinson's disease were conducted by Shanahan et al. (2017) [36] , Carapellotti et al. [31] , Berti et al. [37] , and Rocha et al. [90] , all of those were confined to randomised controlled clinical trials. By conducting a more recent search and extending our analysis to RCTs and non-RCT quantitative studies, our review captured more of the therapies currently being implemented in clinical practice. Our review suggests good attendance for the telehealth mode of delivery in chronic diseases, possibly because digital delivery reduces geographical, environmental, economic, and commute barriers [91] . Some technological difficulties can be encountered with digital delivery [84] such as Internet and usability problems and the need for training and guidance in how to operate the technology. Nevertheless, the reviewed articles did not directly analyse the risk of falls with online delivery or when using video modes. For people with ere are several clinical implications of this systematic review. Dancing was shown to be clinically feasible, with high levels of adherence by participants and considerable interest in future classes. Many of the publications that we reviewed supported the need to increase access to community dance classes to improve exercise capacity and wellbeing, as well as to increase the opportunity for people living with Parkinsonism to socialise. For face-to-face dance classes, there is a need to determine how to reduce barriers to participation, including transportation, access, and cost, (please see [1, 92] ). For digital modes of dancing, clinical protocols are needed to support safe and sustainable implementation and guidance in the use of technology. In addition, it could be argued that a need exists for credentialing programs for dance teachers and practitioners, to ensure evidence-based and effective delivery of this form of structured exercise [93] as well as protocols for clinicians and dance teachers to ensure safe and effective delivery. In the current global context of the COVID-19 pandemic, there is arguably a need to further explore digitally delivered dance and other forms of physical activity for people living with chronic neurological conditions [91, 94] . Despite the systematic review being informed by the Cochrane guidelines, there were several limitations. Most studies included people with mild-moderate disease. e findings might not generalise to people with end-stage disease or very old people, or those who cannot access faceto face classes or digital technologies. Many trials did not control for the effects of levodopa or other Parkinson's medications. Intervention duration and frequency were reported; however, none of the studies documented the intensity of dance therapy. Although some large, significant effects were demonstrated, these need to be considered in light of the moderate to high risk of bias in many studies, especially those that were not randomised trials. Although dance and music were shown to have benefit for people living with PD, the most effective dance genre or music type require further exploration [95] . Quality of life can be adversely affected by Parkinsonism [3, 5] , and the mechanisms by which arts-health therapies such as dance and music can improve health-related quality of life warrant further exploration [95] . Also, the reviewed articles were in the English-language, limiting generalisability to non-English speaking cultures and their associated dance genres. To conclude, dance is safe and feasible for some people in the early to midstages of PD, provided that safety precautions and training are incorporated into design and delivery. ere are positive associations between therapeutic dancing and improvements in gait, balance, movement disorders, and disability. For some individuals, there can be improvements in quality of life. ere was preliminary evidence that delivery of dancing for PD online is beneficial for some people, although there is a need to verify the efficacy and safety of this modality, especially for people who are frequent fallers. Data are available on request to the corresponding author. e authors declare that there are no conflicts of interest regarding the publication of this paper. Mobilizing Parkinson's disease: the future of exercise Measuring outcomes in Parkinson's disease: a multi-perspective concept mapping study Determinants of health-related quality of life in Parkinson's disease: a systematic review Parkinson's disease caregiver strain in Singapore Patients' self-assessment of disease and symptom severity in Parkinson's disease Stride length regulation in Parkinson's disease: normalization strategies and underlying mechanisms Effects of exercise therapy on postural instability in Parkinson disease A randomized controlled trial to reduce falls in people with Parkinson's disease Predictive factors of concerns about falling in people with Parkinson's disease: a 3-year longitudinal study Cueing training in the home improves gait-related mobility in Parkinson' disease: the RESCUE trial Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study Epidemiology of Parkinson's disease European Physiotherapy Guideline for Parkinson's Disease, KNGF/ParkinsonNet Barriers to exercise in people with Parkinson disease A randomized controlled trial of movement strategies compared with exercise for people with Parkinson's disease A home program of strength training, movement strategy training and education did not prevent falls in people with Parkinson's disease: a randomised trial Aquatic exercise therapy for people with Parkinson disease: a randomized controlled trial An exercise intervention to prevent falls in people with Parkinson's disease: a pragmatic randomised controlled trial Movement disorders in people with Parkinson disease: a model for physical therapy Aerobic exercise intervention improves aerobic capacity and movement initiation in Parkinson's disease patients Effects of a flexibility and relaxation programme, walking, and nordic walking on Parkinson's disease Community walking in people with Parkinson's disease Active-assisted cycling improves tremor and bradykinesia in Parkinson's disease Boxing for Parkinson's disease: has implementation accelerated beyond current evidence? Tai chi and postural stability in patients with Parkinson's disease Dancing for Parkinson disease: a randomized trial of Irish set dancing compared with usual care Dance therapy for Parkinson's disease: a randomised feasibility trial Community-based adapted tango dancing for individuals with Parkinson's disease and older adults Why dance for Parkinson's disease Dance erapy" as a psychotherapeutic movement intervention in Parkinson's disease e efficacy of dance for improving motor impairments, non-motor symptoms, and quality of life in Parkinson's disease: a systematic review and meta-analysis Effects of dance therapy on cognitive and mood symptoms in people with Parkinson's disease: a systematic review and meta-analysis More than just dancing: experiences of people with Parkinson's disease in a therapeutic dance program Dance as an intervention for people with Parkinson's disease: a systematic review and metaanalysis Effects of dance practice on functional mobility, motor symptoms and quality of life in people with Parkinson's disease: a systematic review with meta-analysis Dance for people with Parkinson disease: what is the evidence telling us? Argentine tango in the care of Parkinson's disease: a systematic review and analysis of the intervention Towards a methodology for developing evidence-informed management knowledge by means of systematic review e PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration EndNote web: web-based bibliographic management Parkinsonism: onset, progression, and mortality e PEDro scale provides a more comprehensive measure of methodological quality than the Jadad scale in stroke rehabilitation literature e PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study Reliability of the PEDro scale for rating quality of randomized controlled trials e JBI model of evidence-based healthcare e Handbook of Research Synthesis and Meta-Analysispp. 221-235, Russell Sage Foundation e effects of nonnormal distributions on confidence intervals around the standardized mean difference: bootstrap and parametric confidence intervals An evaluation of alternative methods for computing standardized mean difference effect size Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs Estimating the mean and variance from the median, range, and the size of a sample Chapter 6: choosing effect measures and computing estimates of effect Are the effects of community-based dance on Parkinson disease severity, balance, and functional mobility reduced with time? A 2-year prospective pilot study A randomized controlled feasibility trial exploring partnered ballroom dancing for people with Parkinson's disease Sardinian folk dance for individuals with Parkinson's disease: a randomized controlled pilot trial Effect of virtual reality dance exercise on the balance, activities of daily living, and depressive disorder status of Parkinson's disease patients Tango for treatment of motor and nonmotor manifestations in Parkinson's disease: a randomized control study Effects of tango on functional mobility in Parkinson's disease: a preliminary study Effects of dance on gait and balance in Parkinson's disease: a comparison of partnered and nonpartnered dance movement Effects of dance on movement control in Parkinson's disease: a comparison of Argentine tango and American ballroom Randomized controlled trial of community-based dancing to modify disease progression in Parkinson disease Turo (Qi Dance) program for Parkinson's disease patients: randomized, assessor blind, waiting-list control, partial crossover study A randomized controlled trial to investigate the impact of tango Argentino versus tai chi on quality of life in patients with Parkinson disease: a short report A comparison of Irish set dancing and exercises for people with Parkinson's disease: a phase II feasibility study e effects of adapted tango on spatial cognition and disease severity in Parkinson's disease Effects of dance on motor functions, cognitive functions, and mental symptoms of Parkinson's disease: a quasi-randomized pilot trial Feasibility of home exercises to enhance the benefits of tango dancing in people with Parkinson's disease Karate and dance training to improve balance and stabilize mood in patients with Parkinson's disease: a feasibility study erapeutic Argentine tango dancing for people with mild Parkinson's disease: a feasibility study e potential benefits of Zumba Gold in people with mild-tomoderate Parkinson's: feasibility and effects of dance styles and number of sessions Short duration, intensive tango dancing for Parkinson disease: an uncontrolled pilot study Augmented reality-based dance intervention for individuals with Parkinson's disease: a pilot study A comparison of dance interventions in people with Parkinson disease and older adults e influence of dance on selected risk factors of falls in Parkinson's disease patients-a pilot study Is Irish set dancing feasible for people with Parkinson's disease in Ireland? Feasibility of an intensive trial of modern dance for adults with Parkinson disease Impact of a weekly dance class on the functional mobility and on the quality of life of individuals with Parkinson's disease Effects of a short duration, high dose contact improvisation dance workshop on Parkinson disease: a pilot study Balance, body motion, and muscle activity after high-volume short-term dance-based rehabilitation in persons with Parkinson disease: a pilot study Impacts of dance on cognition, psychological symptoms and quality of life in Parkinson's disease Adapted Tango improves aspects of participation in older adults versus individuals with Parkinson's disease e impact of Brazilian Samba on Parkinson's disease: analysis by the disease subtypes Feasibility and preliminary efficacy of a telerehabilitation approach to group adapted tango instruction for people with Parkinson disease Effects of a balletbased dance intervention on gait variability and balance confidence of people with Parkinson's," Arts & Health Exercise and Parkinson disease: comparing tango, treadmill, and stretching Long-term effects of dance for PD on selfefficacy among persons with Parkinson's disease Effects of dance on balance and gait in severe Parkinson disease: a case study Differential effects of tango versus dance for PD in Parkinson disease Complementary physical therapies for movement disorders in Parkinson's disease: a systematic review Leveraging telemedicine for chronic disease management in low and middle-income countries during Covid-19 Longterm effects of exercise and physical therapy in people with Parkinson disease Recommendations for implementing tango classes for persons with Parkinson Disease Online dance therapy for people with Parkinson's disease: feasibility and impact on consumer engagement Rehabilitation, exercise therapy and music in patients with Parkinson's disease: a meta-analysis of the effects of music-based movement therapy on walking ability, balance and quality of life is review was funded and copartnered by La Trobe University and Parkinson's Victoria. e authors thank the La Trobe University librarians who ably assisted with the database searches and Parkinson's Victoria for supporting this project.