key: cord-0863640-593v6l2g
authors: Emili, R.; Natalucci, V.; Marini, C. F.; Lucertini, F.; Vallorani, L.; Annibalini, G.; De Santi, M.; Donati Zeppa, S.; Agostini, D.; Gervasi, M.; Panico, A.; Sisti, D.; Rocchi, M.B.L.; Barocci, S.; Flori, M.; Brandi, G.; Stocchi, V.; Catalano, V.; Villarini, A.; Barbieri, E.
title: Beneficial effects of exercise in oncology - MoviS: ‘Movement and Health Beyond Care’
date: 2020-09-30
journal: Annals of Oncology
DOI: 10.1016/j.annonc.2020.08.359
sha: 682edee53152ed74b79eab96a6aef113650b5a62
doc_id: 863640
cord_uid: 593v6l2g

nan

Background: Food habits change in early breast cancer (EBC) patients (pts) during chemotherapy has been poorly studied in literature. Primary aim of this study was to evaluate food preferences and consumption of EBC pts before and after adjuvant chemotherapy.

We conducted a prospective cohort study at Medical Oncology Unit and Breast Unit of ASST Spedali Civili of Brescia (Italy). From April 2014 to June 2018 205 EBC pts were enrolled and interviewed by a dietician to assess quantity and frequency of several foods, soft drinks and alcoholic beverages intake. Additional 205 EBC patients, who were not interviewed by the dietitian, were selected as control group.

Results: A statistically significant reduction of the following foods and beverage was reported after chemotherapy: pasta or rice (p¼0.009), bread (p<0.0001), breadsticks/crackers (p<0.0001), red meat (p<0.0001), fat salami (p<0.0001), lean salami (p<0.0001), fresh cheese (p¼0.039), aged cheese (p¼0.011), yogurt (p¼0.022), sugar (p<0.0001), soft drinks (p¼0.003), alcoholic beverages such as wine (p<0.0001), beer (p<0.0001), schnapps (p<0.001), and condiments such as oil (p¼0.029) and butter (0.014). Conversely, fruit consumption consistently increased (p<0.0001). As a consequence of these food habits changes body weight did not increase, despite reduction in physical activity. Body weight remained stable also in the control group, indirectly suggesting that food habit variation was not influenced by the dietician.

Conclusions: This prospective study shows that EBC patients tend to adopt "healthier dietary patterns" during adjuvant chemotherapy leading to a non-change in body weight, despite reduction of physical activity.

Clinical trial identification: NCT03210441.

Legal entity responsible for the study: Alfredo Berruti.

Funding: Has not received any funding. Methods: Our study included 11 PCOS-associated single nucleotide polymorphisms as instrumental variables identified by the latest genome-wide association study.

Individual-level genetic summary data of participants were obtained from the Breast Cancer Association Consortium, with a total of 122 977 cases and 105 974 controls. The Inverse-weighted method was applied to estimate the causality between genetically predicted PCOS and breast cancer risk. To further evaluate the pleiotropy, the weighted median and MR-Egger regression method were implemented as well.

Results: Our study demonstrated that genetically predicted PCOS was causally associated with an increased risk of overall breast cancer (odds ratio (OR) ¼ 1.07; 95% confidence interval (CI) ¼ 1.02-1.12, p ¼ 0.005). The subgroup analyses according to immunohistochemical type further illustrated that genetically predicted PCOS was associated with an increased risk of estrogen receptor (ER)-positive breast cancer (OR ¼ 1.09; 95% CI ¼ 1.03-1.15, p ¼ 0.002), while no causality was observed for ERnegative breast cancer (OR ¼ 1.02; 95% CI ¼ 0.96-1.09, p ¼ 0.463). Additionally, no horizontal pleiotropy was found in our study.

Conclusions: Our findings indicated that PCOS was likely to be a causal factor in the development of ER-positive breast cancer, providing a better understanding for the etiology of breast cancer and the prevention of breast cancer.

Legal entity responsible for the study: Jianxing He. Using a t test for independent samples, with 0.05 alpha and 0.80 1-beta will require 60 subjects per group. Considering an expected drop-out of 30%, a total of 172 patients will be recruited.

The targeted exercise oncology through multidisciplinary team would like to provide a coordinated program of cancer care to improve health care quality, improve prognosis, increase survival times and QoL and reduce the risk of BC recurrence. 

Awareness of all 4 aspects of their BC was highest among pts with degreed education (48%), with 63% reporting active involvement in treatment decisions; and lowest amongst those with no degreed education (30%), with 47% reporting active involvement. Pre/peri-menopausal pts were most aware of all 4 aspects of their BC (46%) (post-menopausal pts (31%). 90% of all pts cited their doctor as an information source. The second most common source was the internet amongst pre/peri-menopausal pts (57%) and family/ friends for post-menopausal pt (39%). 71% who very much agree with the statement 'I am satisfied with how well I am coping with my illness' feel they are actively involved in treatment decisions compared to 44% of who do not agree at all with the statement. Conclusions: A high proportion of pts satisfied with how they were coping with their illness were actively involved in their treatment decisions. Knowledge and involvement were highest in pts with degreed education and amongst pre/peri-menopausal pts

Eli Lilly have paid Adelphi Real World a fee for conducting this research and drafting this abstract: Eli Lilly and Company. E. Clayton: Honoraria (institution), Eli Lilly have paid Adelphi Real World a fee for conducting this research and drafting this abstract: Eli Lilly and Company

241P Germline genetic features of Chinese patients with breast cancer

Germline DNA samples were sequenced using a next-generation sequencing (NGS) multi-gene panel. The primary outcome was identification of a pathogenic germline mutation. Results: Of 1235 subjects who underwent clinical germline sequencing, 100 (8.1%) had pathogenic germline mutations and 419 (33.9%) had variants of uncertain significance. 60 (4.9%) subjects who had pathogenic germline mutations were less than 50 years old. BRCA1 mutations were identified in 44 (3.6%) subjects and 34 (2.8%) had BRCA2 mutations; 19 (1.5%) subjects had germline mutations related to homologous recombination repair (HRR) (4 with mutations in BRAD1, 4 with mutations in CHEK2, 4 with mutations in PALB2, 2 had mutations in ATM, 2 had mutations in BLM, 2 had mutations in BTIP1, 1 had a mutation in FANCA); 2 (0.2%) had mutations related to lynch syndrome

Chinese breast cancer patients, nearly 1 in 10 individuals had germline mutations, mainly in BRCA1/2 and HRR related genes. Legal entity responsible for the study: Zhujiang hospital. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest

242P Reclassification of variants of unknown significance in BRCA 1/2 genes for the improvement of care quality in oncological genetic council units

Background: The detection and correct interpretation of a mutation as a variant of unknown significance (VUS) is one of the most challenging points in genetic council units (GCU)