key: cord-0862982-a4ybjza1 authors: nan title: Erythema multiforme after SARS-CoV-2 messenger RNA vaccination date: 2021-12-01 journal: QJM DOI: 10.1093/qjmed/hcab303 sha: bcab3f4a6e1a85197d8aa5984ca949b17661b431 doc_id: 862982 cord_uid: a4ybjza1 nan reported although underreporting may be partially responsible for the apparent paucity of cases, given the tremendous number of COVID-19 vaccinations that have been administered globally. [2] [3] [4] [5] Cutaneous reactions due to COVID-19 mRNA vaccines in areas distant from the injection site have occurred in about 2% of vaccine recipients, but more importantly, 83% of individuals with a cutaneous reaction after the first vaccination may receive their second dose without a recurrence of the symptoms, as in the present case. 6 Clinicians should be aware of the diversity of cutaneous reactions due to COVID-19 mRNA vaccines and should inform and reassure patients with an initial skin reaction that they may safely receive their second vaccination. Photographs Consent to publish the details of the case was obtained from the patient. Erythema multiforme: recognition and management Erythema multiforme after CoronaVac vaccination Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases Cutaneous reactions after SARS-COV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases European Medicines Agencyj COVID-19 vaccine safety update COMIRNATY BioNTech Manufacturing GmbH Incidence of cutaneous reactions after messenger RNA COVID-19 vaccines A-G) Round, well-defined papules with a target-like appearance (yellow arrows) distributed symmetrically on the acral extremities We thank Mr James R. Valera for his assistance with editing the manuscript.Conflict of interest. None declared.