key: cord-0860990-e7hkged6 authors: Jia, Hui; Chang, Yuele; Zhao, Long; Li, Yunxia; Chen, Lei; Zhang, Qian; Lou, Xianzhi; Li, Chenwei; Xia, Shuyue title: The Role of Fever Clinics in the Strategic Triage of Suspected Cases of Imported COVID-19 date: 2021-05-25 journal: Int J Gen Med DOI: 10.2147/ijgm.s302797 sha: 3eafecdb1215c3eb4bfa89f0b9099e2bc7d8573d doc_id: 860990 cord_uid: e7hkged6 INTRODUCTION: Novel coronavirus pneumonia (COVID-19) is an acute respiratory infectious disease, which has the characteristic of human-to-human transmission and is extremely contagious. Correctly standardizing the process of early screening of infection or suspected cases in the fever clinic has become a key part of the fight against the pandemic. METHODS: A retrospective analysis of patients in the fever clinic of Shenyang Medical College Affiliated Central Hospital from January 23 to March 1, 2020, was conducted in the present study. RESULTS: It was found that 16 suspected cases of COVID-19 in the fever clinic were diagnosed with respiratory infections, accounting for 0.59%. CONCLUSION: In case of a negative result in the second nucleic acid test, strategic triage and typing might be more conducive for the following nucleic acid tests for suspected cases in order to prevent the spread of the epidemic caused by missed diagnosis. Since December 2019, the novel coronavirus pneumonia (COVID-19) epidemic in China has been testing the country's medical disease prevention and treatment system. The World Health Organization declared the outbreak as a public health emergency of international concern on January 30, 2020, and designated the outbreak as a pandemic on March 11, 2020 . The disease is an acute respiratory infection caused by the novel coronavirus. 1, 2 It spreads via human-to-human transmission through respiratory droplets and contact 3, 4 and is extremely contagious. The initial symptoms of infected patients are primarily fever, fatigue, and dry cough but gradually develop into severe symptoms such as dyspnea. It has been reported that CoV infections could produce significant changes to multiple progress of autophagy, and autophagy could make an important role in the viral life cycle. 5 Accumulating evidence suggested that the structural protein-spike (S) encode by the genomes of CoVs could make the virus to enter host cells. 6 Many asymptomatic infections with positive nucleic acid results have also been found. Due to the rapid outbreak of the epidemic, there is no cure, though researchers all over the world are developing antiviral vaccines. The outpatient clinics in hospitals are important places wherein susceptible subjects may gather. Reducing the contact between suspected or confirmed patients and ordinary outpatients is a key link to protect the latter, prevent cross-infection, and stop the spread of the epidemic. Thus, the data of outpatient visits in our hospital from January to March 2020 were analyzed with the aim to elaborate the rationality of launching fever clinics in general hospitals during the process of receiving new cases of respiratory infectious diseases. According to the Diagnosis and Treatment Plan of COVID-19 of the National Health Commission, 7 from January 23 to March 1, 2020, in accordance with the standard of a clear or suspicious epidemiological history, a total of 2724 patients in the fever clinic of Shenyang Medical College Affiliated Central Hospital as well as a total of 4154 patients in the respiratory outpatient department were included in the study. The flow chart of the hospital visits is shown in Figure 1 . Patient classification: fever clinics and general clinics; According to the diagnostic criteria of pneumonia, suspected and confirmed fever clinics are identified as pneumonia or non-pneumonia, non-pneumonia includes other systemic diseases, such as acute gastroenteritis and chronic hepatitis B. This paper analyzed the data of patients visiting general clinics and fever clinics in our hospital from January 2020 to March 2020, and explore the effectiveness of triage strategy which reduce cross infection. All fever patients in the hospital were required to visit the fever clinics, and the patients who came to our hospital and planned to refer to the general clinic were selected for predictive questioning. If the patients were found to have fever, they would be required to visit the fever clinics by a special channel; the patients without fever would refer to each department for clinic treatment. Diagnostic criteria for community acquired pneumonia were as follows: 1) Community onset. 2) (a) Increased symptoms of a recent cough, sputum or existing respiratory disease with or without chest pain/dyspnea/hemoptysis; (b) fever; (c) pulmonary consolidation signs and/or moist rales; D. WBC >10×10 9 /L or <4×10 9 /L with or without left neutrophil nuclei. 3) Chest imaging examination showed patchy or patchy infiltrating shadow or interstitial changes with or without pleural effusion. Meeting any of the criteria of 1, 3 and 2, and with the exception of pulmonary tuberculosis, lung tumor, non-infective interstitial lung disease, pulmonary edema, atelectasis, pulmonary embolism, pulmonary infiltration and eosinophils pulmonary vasculitis, the clinical diagnosis of community acquired pneumonia could be established. 7 According to the clinical manifestations, the suspected cases were classified as follows: pneumonia type, in which there existed an opacity of viral pneumonia in the imaging examination, and non-pneumonia type, with only fever or respiratory symptoms. Medical staff in fever clinics should strictly abide by the Law of the People's Republic of China on the Prevention and Control of Infectious Diseases and the relevant laws and regulations issued by the country during the epidemic prevention and control of infectious diseases to carry out daily disinfection management of fever clinics, isolation management of patients with fever, and protection of medical staff to avoid cross-infection. 8 Nucleic acid detection: Extraction: The QIAamp Viral RNA Mini Kit (Beijing Jinhaozong Co., Ltd. Jingjing Machinery Equipment 20160028) was used, and the nucleic acid was extracted according to the instructions. PCR amplification: Each sample was tested with the 2019-nCoV ORF1ab/N reaction solution and judged based on the test results. A negative control and positive control were set for each experiment, and both participated in the nucleic acid extraction. Detection of the amplification: The PCR amplification tubes with the loaded sample were transferred to an automatic fluorescence quantitative PCR detector for amplification detection. From January 23 to March 1, 2020, there were 2724 cases of fever among the clinic visits in the Affiliated Central Hospital of Shenyang Medical College, including 2287 cases of respiratory infection, 160 cases of acute gastrointestinal inflammation, 108 cases of simple fever, 104 cases of chronic hepatitis B, 18 cases of upper respiratory tract infection, 11 cases of urinary tract infection, 5 cases of bacterial enteritis, 4 cases of bacterial pneumonia, 4 cases of epidemic adenitis, and 3 cases of chickenpox. Among these patients, the cases with respiratory infection accounted for 88.7%, and those with other etiologies accounted for 11.3%. Among the 2287 patients with fever and respiratory infection, the 16 suspected cases with COVID-19 accounted for 0.7%. All such cases were negative after two nucleic acid tests, with 6 cases of the pneumonia type and 10 cases of the non-pneumonia type. However, of the pneumonia type, one case was positive in the third nucleic acid test and confirmed with the diagnosis of COVID-19, which accounted for 6.25% of the During this period, the sixth version of the national diagnosis and treatment plan of COVID-19 was implemented, and of the 16 patients considered as suspected cases of COVID-19, 12 had an epidemiological history (in accordance with the sixth version of the diagnosis and treatment plan of COVID-19), accounting for 75%, and 4 did not have an epidemiological history, accounting for 25%. The average age of the patients was 38 ± 12 years, with a male:female ratio of 5:11. The clinical manifestations were as follows: Fever with a body temperature of 37.3°C-38.9°C, accounting for 93.75% (15/16); sore throat, accounting for 37.5% (6/16); cough, accounting for 31.25% (5/16); and difficulty breathing, accounting for 6.25% (1/16). There was no diarrhea in these patients. The average time from the onset of disease to the visit was 4.06 ± 2.38 (1-9 days). The white blood cell count of the suspected cases at the initial visit was (6.74 ± 3.60) × 10 9 /L, the percentage of neutrophils was 68.03 ± 12.08%, and the absolute count of neutrophils was (4.92 ± 2.84) × 10 9 /L. The percentage of lymphocytes was 25.88 ± 11.23%, and the absolute count of lymphocytes was (1.77 ± 0.85) × 10 9 /L. The ratio of the absolute count of neutrophils/lymphocytes was 3.35 ± 2.28. Suspected cases and results of the 14-day follow-up: Except for the 1 confirmed case, 15 of the suspected cases tested negative for IgM and IgG during the 14-day follow-up without clinical respiratory manifestations and with normal body temperature. The details of the specific disease screening at the fever clinics are illustrated in Figure 2 . The pre-inspection triage, as the outpost of the outpatient clinic, started after the outbreak of COVID-19 in December 2019. In accordance with the Law of the People's Republic of China on the Prevention and Control of Infectious Diseases, the hospital initially stipulated COVID-19 as a class B infectious disease according to the requirements of the management of class A infectious diseases, 7 and the fever clinic process was formulated. Based on the different concepts of the epidemiological history in the Diagnosis and Treatment Plan of COVID-19 issued by the National Health Commission, a management plan for "observed cases," "suspected cases," and "confirmed cases" was formulated. We conducted a retrospective analysis of patients in the fever clinic from January 23 to March 1, 2020, and found that patients with respiratory infection accounted for 88.7% of those who went to the fever clinic. Among these patients, 16 were suspected of COVID-19 infection, accounting for 0.59%. These cases were negative after two nucleic acid detection tests, with 6 cases of the pneumonia type and 10 cases of the non-pneumonia type. Among those of the pneumonia type, however, one case was positive in the third nucleic acid test and finally diagnosed with COVID-19. Therefore, it could be suggested that pre-inspection triage might play an important role in the detection of suspected cases. At the beginning of the epidemic, when little was known about COVID-19, it might have been more beneficial to divide the suspected cases into the pneumonia type and non-pneumonia type, which may have been more conducive for the close observation of suspected cases of the pneumonia type if the second nucleic acid test was negative. With the persistence of the condition, such as via fever and specific pulmonary images, it is necessary to test for a third time (or more) so as not to lead to the spread of the epidemic as a result of the missed diagnosis. Besides, laboratory parameters could also be the diagnosis for detection of COVID-19. Accumulated studies has reported that many kinds of comorbidities are relative with severe degree of COVID-19, such as diabetes mellitus, dyslipidemia, and thyroid disease. [9] [10] [11] [12] According to the an meta analysis, 13 serum procalcitonin, C-reactive protein, D-dimer and LDH are higher in patients with severe COVID-19, while serum almanuin is lower than that of non-severe COVID-19 patients. On April 1, 2020, a research team from Germany published a paper entitled "Virological assessment of hospitalized patients with COVID-2019" online in Nature, which revealed the process of the novel coronavirus invading the human body from the perspective of human virus dynamics. Nine patients from Munich were included in the study. Through the monitoring and analysis of the biological samples of the patients, it was found that the novel coronavirus rapidly replicated in the oropharynx/nasopharynx during the early stage of infection, especially within the first 5 days of the onset of symptoms. The RNA load was as high as 7.11×10 8 copies/swab, making it easy to be spilled out of the body and cause widespread transmission. Therefore, once a patient develops symptoms, nucleic acid testing and closed-loop management are very important. 14 As of June 29, 2020, it took 13 days for the number of confirmed cases with COVID-19 in the world to increase from 1 to 2 million and only 6 days to increase from 9 to 10 million. The duration of the newly added million was the shortest since the outbreak, indicating that the spread of the epidemic is very quick. If the control is ineffective, the speed of expansion will increase as the population base increases, and the time it takes to double the number of patients will be shortened. The global epidemic of COVID-19 has not yet reached its peak and will rise in the future. Nucleic acid detection is an important technique for the control of COVID-19. It can not only assist in the diagnosis of patients with symptoms but also screen in advance those who do not have symptoms. This is an essential means of finding patients and the sources of infection in time, [16] [17] [18] as the establishment of scientific and reasonable pre-inspection triaging and fever clinics in a hospital might play an irreplaceable role in the early detection, early diagnosis, early reporting, and early isolation of suspected cases. Resuming work and production so as to gradually normalize national production and life while keeping the epidemic at a low level is the biggest challenge currently. Some limitations still existed in this study. Firstly, we just analyzed the outpatients in our hospital, which is a single center and limited number of patients. Besides, as the subjects of this study was patients in clinic, it failed to systematically count the indicators, which was also another defect of this study. Our study found that there is rationality and necessity of establishing fever clinics in general hospitals in the triage of new respiratory infectious diseases, which could avoid missed diagnosis and the possibility of epidemic spread. This study was supported by the establishment of a novel coronavirus infection system for rapid triage of pneumonia and early detection of cryptogenic infections YJ2020-9-019. 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