key: cord-0859829-52tq2jnc
authors: Palladino, Raffaele; Bollon, Jordy; Ragazzoni, Luca; Barone-Adesi, Francesco
title: Effect of Implementation of the Lockdown on the Number of COVID-19 Deaths in Four European Countries
date: 2020-11-04
journal: Disaster medicine and public health preparedness
DOI: 10.1017/dmp.2020.433
sha: 5a2b543752b2e7578ba2823f6ff9e223df265ab3
doc_id: 859829
cord_uid: 52tq2jnc

nan

The coronavirus disease (COVID-19) epidemic has rapidly evolved into a global health emergency. 1 However, there has been a substantial heterogeneity in timing and magnitude of the public health response to the pandemic among different countries. [1] [2] [3] [4] A key factor in explaining why China was successful in curbing the epidemic is that the government implemented containment measures in the Hubei Province in the very early phase of the epidemic. 2 On the contrary, Europe has been slower in responding to the emergency. In France, Italy, Spain, and the UK, the 4 European countries that have been impacted the most by the COVID-19 emergency, lockdown was enforced 13 to 16 days after Hubei's, when normalizing for the time when the outbreak hit 50 cases in all countries. 2 This prompts the question of how many COVID-19 deaths could have been avoided during the early phase of the pandemic if containment measures in European countries had aligned with China's lockdown.

We modeled the daily number of COVID-19 deaths in France, Italy, Spain, and the UK from January 23 to August 15. Data were downloaded from the COVID-19 Data Repository. 1 The time-series included a small amount of days in which the number of deaths was negative. We considered these figures as missing values and replaced them, interpolating the number of deaths recorded in the previous and in the following day. We estimated the effect of the national lockdown implementing an Interrupted Time Series analysis. 5 Specifically, for each country, we modeled the time-series of daily deaths (Y t ) using the following quasi-Poisson regression model:

where T is the time elapsed since the start of the observation period (January 23); T 2 is the time elapsed since the implementation of the lockdown (set to 0 before the lockdown); Y t is the number of new deaths at time T; α is the intercept of the model; β 1 represents the trend of new cases before the lockdown; β 2 is the slope change following the lockdown; and e t is the error term of the model.

To take into account the COVID-19 incubation period and the mean time between the symptoms onset and death, we assumed an 18-day lag between the national implementation of the lockdown and the start of its effects. 6 Then, we created 4 separate counterfactual scenarios by predicting the daily number of deaths that would have been observed in the 4 countries if the lockdown had been implemented at the same time as Hubei's (3 days after the outbreak hit 50 cases). This timing would correspond to the following dates: February 25 for Italy, March 2 for France, March 3 for Spain, and March 6 for the UK. Finally, we estimated the relative change in the number of total deaths in the counterfactual scenario, compared to the observed one. All the analyses were performed using R software (R Foundation for Statistical Computing, Vienna, Austria). Figures 1 and 2 display the daily and total number of deaths in the 4 countries. As of August 15, there were 31 174, 35 449, 30 731, and 41 361 deaths in France, Italy, Spain, and the UK, respectively. If an early lockdown had been implemented, the death toll would have been 2461 (95% CI: 1440 to 4272), 6769 (95% CI: 5652 to 8135), 6792 (95% CI: 4154 to 11 525), and 4071 (95% CI: 3281 to 5067), corresponding to a 92% (95% CI: 86% to 95%), 81% (95% CI: 77% to 84%), 78% (95% CI: 62% to 86%), and 90% (95% CI: 88% to 92%) relative reduction, as compared with observed data.

We found that a more rapid and homogeneous response would have avoided a substantial number of deaths. Our results underline the need of strengthening public health emergency preparedness at national and global levels. Currently, no health care system can sustain an Author Contributions. RP, JB, and FBA conceived and designed the study; JB and FBA analyzed the data; RP, JB, LR, and FBA wrote the paper; and all authors approved the final version of the manuscript.

Conflict(s) of Interest. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this paper.

Ethical Standards. The study was based on publicly available aggregate data. No ethics committee approval was necessary.

Novel Coronavirus COVID-19 (2019-nCoV) Data Repository

SARS-CoV-2 and Europe: timing of containment measures for outbreak control

Coronavirus government response tracker

Excess deaths and hospital admissions for COVID-19 due to a late implementation of the lockdown in Italy

Interrupted time series regression for the evaluation of public health interventions: a tutorial

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Disaster Medicine and Public Health Preparedness