key: cord-0858240-g8qjig85
authors: Zhang, Man; Zhang, Jing; Shi, Huibo; Liu, Bin; Zeng, Fanjun
title: Viral Shedding Prolongation in a Kidney Transplant Patient with COVID‐19 Pneumonia
date: 2020-05-13
journal: Am J Transplant
DOI: 10.1111/ajt.15996
sha: 16675574b45ef195718aba49d86a1cc8a6fa4c1a
doc_id: 858240
cord_uid: g8qjig85

Coronavirus disease 2019 (COVID‐19) pandemic sweeps the globe. The information regarding the kinetic changes of SARS‐CoV‐2 in immunosuppressed patients is unclear. Herein, we present a case of prolonged viral shedding in a transplant patient with COVID‐19 pneumonia. A 49‐year‐old male kidney recipient was admitted to the hospital on February 7, 2020, for fever and fatigue. He was a permanent resident in Wuhan, China, and began having symptoms on January 29 (day 1 of illness). His maintenance immunosuppressive regime was consisted of tacrolimus (TAC, 1mg twice a day, orally), mycophenolate mofetil (MMF, 0.5g twice a day, orally) and prednisone (Pred, 5mg daily, orally) triple combination.

This article is protected by copyright. All rights reserved Coronavirus disease 2019 (COVID-19) pandemic sweeps the globe. The information regarding the kinetic changes of SARS-CoV-2 in immunosuppressed patients is unclear. Herein, we present a case of prolonged viral shedding in a transplant patient with COVID-19 pneumonia.

A 49-year-old male kidney recipient was admitted to the hospital on February 7, 2020, for fever and fatigue. He was a permanent resident in Wuhan, China, and began having symptoms on January 29 (day 1 of illness). His maintenance immunosuppressive regime was consisted of tacrolimus (TAC, 1mg twice a day, orally), mycophenolate mofetil (MMF, 0.5g twice a day, orally) and prednisone (Pred, 5mg daily, orally) triple combination. On admission, laboratory tests non-immunocompromised patients who may become virus carriers [2] . Accordingly, recovered patients are instructed to continue isolation and observation after discharge. They receive repeated Accepted Article examinations during the period. Secondly, SARS-CoV-2 RNA "turned positive" revealed prolonged viral shedding rather than "recurrence", which was also described in recipients with respiratory syncytial virus infection [3] . The median duration of virus shedding was 20 days in general population with COVID-19 [4] . However, the actual shedding time after the illness onset Further studies should be needed to investigate the proportion of immunocompromised patients with prolonged nucleic acid conversion.

Detection of SARS-CoV-2 in different types of clinical specimens

Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19

Prolonged Respiratory Viral Shedding in Transplant Patients

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

The authors of this manuscript have no conflicts to disclose as described by the American Journal of Transplantation.