key: cord-0856399-azc1ysoy
authors: Flores-Rebollar, Armando
title: Reply: Subacute thyroiditis after anti-SARS-CoV-2 (Ad5-nCoV) vaccine()
date: 2022-04-26
journal: Enferm Infecc Microbiol Clin (Engl Ed)
DOI: 10.1016/j.eimce.2022.03.005
sha: e7969ded9cf2f6e4758f8584ec40d0c225d6f4a5
doc_id: 856399
cord_uid: azc1ysoy

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Yasri and Wiwanitki's 1 letter on my case report 2 speculates as to the association between the COVID-19 vaccination, blood hyperviscosity and thyroid dysfunction. No pathophysiological relationship between hyperviscosity andäberrant thyroid functionḧas been reported. False thyroid hormone test results due to blood hyperviscosity should not be confounded with thyroid dysfunction.

Hyperviscosity caused by acellular components (proteins), which may be monoclonal or polyclonal, are a known cause of potential interference in thyroid immunoassays. 3 These correspond to uncommon entities including: Waldenström's macroglobulinaemia, cryoglobulinaemia and multiple myeloma, 4 as well as rheumatic diseases associated with high rheumatoid factor levels. Paraprotein interference in immunoassays used to measure thyroid hormone and thyroid-stimulating hormone (TSH) levels 5 has been extensively and specifically studied; although false results are mostly reported in total thyroid hormone levels, 3-6 any immunoassay used may be prone to interference. However, such interference is recognisable and does not indicate any thyroid function abnormality.

All the procedures performed in the course of this retrospective study were carried out in accordance with institutional and national research committee ethical standards, and the study was conducted in accordance with World Health Organization (WHO) standards for biomedical and scientific research in humans. Case reports do not require independent ethics committee approval. Informed consent was obtained from and signed by the study participant.

This study received no specific funding from public, private or non-profit organisations.

The author has no conflicts of interest to declare.

Tiroiditis subaguda después de la vacuna anti SARS-CoV-2 (Ad5-nCoV)

Interferences with thyroid function immunoassays: clinical implications and detection algorithm

The prevalence of euthyroid hypertriiodothyroninemia in newly diagnosed multiple myeloma and its clinical characteristics

Interference in thyroid-stimulating hormone determination

Circulating thyroid hormones in a patient with hyperviscosity syndrome

Instituto Nacional de Ciencias Médicas y Nutrición «Salvador Zubirán», Mexico City, Mexico E-mail address: afcalatrava@yahoo