key: cord-0855797-a957qctg
authors: Thacher, Tom D.
title: Vitamin D and COVID-19
date: 2021-02-25
journal: Mayo Clin Proc
DOI: 10.1016/j.mayocp.2021.02.014
sha: 64229fa4490b9b99c67073284c3d493206d12c27
doc_id: 855797
cord_uid: a957qctg

nan

<10 ng/mL. 2 This contextual framework underpins the rationale for studying the therapeutic benefit of vitamin D in In this issue of Mayo Clinic Proceedings, Angelidi and colleagues report the relationship between vitamin D status and hospital outcomes in 144 patients with COVID-19 in New York and Boston early in the pandemic (Feb-May 2020). 3 Using a retrospective cohort design, they found that patients with lower serum 25(OH)D values within 6 months before or during hospital admission for COVID-19 had increased mortality and need for invasive mechanical ventilation. Particular strengths of this study include the racial diversity represented and the consistency of the relationship of 25(OH)D concentrations with mortality and invasive mechanical ventilation across different multivariable models, adjusting for a variety of covariates that could affect illness severity or vitamin D status. The median 25(OH)D concentration was 28 ng/mL, and mortality in those with 25(OH)D values <30 ng/ml was 25%, 

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